2YZC

Crystal structure of uricase from Arthrobacter globiformis in complex with allantoate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004846	molecular_function	urate oxidase activity
A	0006144	biological_process	purine nucleobase metabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0019628	biological_process	urate catabolic process
B	0004846	molecular_function	urate oxidase activity
B	0006144	biological_process	purine nucleobase metabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0019628	biological_process	urate catabolic process
C	0004846	molecular_function	urate oxidase activity
C	0006144	biological_process	purine nucleobase metabolic process
C	0016491	molecular_function	oxidoreductase activity
C	0019628	biological_process	urate catabolic process
D	0004846	molecular_function	urate oxidase activity
D	0006144	biological_process	purine nucleobase metabolic process
D	0016491	molecular_function	oxidoreductase activity
D	0019628	biological_process	urate catabolic process
E	0004846	molecular_function	urate oxidase activity
E	0006144	biological_process	purine nucleobase metabolic process
E	0016491	molecular_function	oxidoreductase activity
E	0019628	biological_process	urate catabolic process
F	0004846	molecular_function	urate oxidase activity
F	0006144	biological_process	purine nucleobase metabolic process
F	0016491	molecular_function	oxidoreductase activity
F	0019628	biological_process	urate catabolic process
G	0004846	molecular_function	urate oxidase activity
G	0006144	biological_process	purine nucleobase metabolic process
G	0016491	molecular_function	oxidoreductase activity
G	0019628	biological_process	urate catabolic process
H	0004846	molecular_function	urate oxidase activity
H	0006144	biological_process	purine nucleobase metabolic process
H	0016491	molecular_function	oxidoreductase activity
H	0019628	biological_process	urate catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE 1AL A 303

Chain	Residue
A	PHE163
A	ILE279
A	HOH540
D	ALA66
D	THR67
D	ASP68
A	LEU174
A	ARG180
A	ALA221
A	LEU222
A	GLN223
A	ASN249
A	HIS251
A	GLY277

---

site_id	AC2
Number of Residues	14
Details	BINDING SITE FOR RESIDUE 1AL B 303

Chain	Residue
B	PHE163
B	LEU174
B	ARG180
B	ALA221
B	LEU222
B	GLN223
B	ASN249
B	HIS251
B	GLY277
B	ILE279
B	HOH448
C	ALA66
C	THR67
C	ASP68

---

site_id	AC3
Number of Residues	13
Details	BINDING SITE FOR RESIDUE 1AL B 304

Chain	Residue
B	ALA66
B	THR67
B	ASP68
B	HOH540
C	PHE163
C	LEU174
C	ARG180
C	LEU222
C	GLN223
C	ASN249
C	HIS251
C	GLY277
C	ILE279

---

site_id	AC4
Number of Residues	14
Details	BINDING SITE FOR RESIDUE 1AL D 304

Chain	Residue
A	ALA66
A	THR67
A	ASP68
D	PHE163
D	LEU174
D	ARG180
D	ALA221
D	LEU222
D	GLN223
D	ASN249
D	HIS251
D	GLY277
D	ILE279
D	HOH477

---

site_id	AC5
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 1AL H 305

Chain	Residue
E	PHE163
E	LEU174
E	ARG180
E	LEU222
E	GLN223
E	ASN249
E	HIS251
E	ILE279
H	ALA66
H	THR67
H	ASP68
H	HOH531

---

site_id	AC6
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 1AL F 306

Chain	Residue
F	PHE163
F	ARG180
F	LEU222
F	GLN223
F	ASN249
F	HIS251
F	GLY277
F	ILE279
F	HOH547
G	ALA66
G	THR67
G	ASP68

---

site_id	AC7
Number of Residues	14
Details	BINDING SITE FOR RESIDUE 1AL G 307

Chain	Residue
F	ALA66
F	THR67
F	ASP68
G	PHE163
G	LEU174
G	ARG180
G	ALA221
G	LEU222
G	GLN223
G	ASN249
G	HIS251
G	GLY277
G	ILE279
G	HOH462

---

site_id	AC8
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 1AL E 308

Chain	Residue
H	LEU222
H	GLN223
H	ASN249
H	HIS251
H	GLY277
H	ILE279
E	ALA66
E	THR67
E	ASP68
E	HOH523
H	PHE163
H	ARG180

---

Functional Information from PROSITE/UniProt

site_id	PS00366
Number of Residues	28
Details	URICASE Uricase signature. LtVLKSTgSeFhgFprdkYttLqettdR

Chain	Residue	Details
A	LEU153-ARG180

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	ACT_SITE: Charge relay system => ECO:0000305|PubMed:18645230

Chain	Residue	Details
A	LYS22
D	LYS22
D	THR67
D	HIS251
E	LYS22
E	THR67
E	HIS251
F	LYS22
F	THR67
F	HIS251
G	LYS22
A	THR67
G	THR67
G	HIS251
H	LYS22
H	THR67
H	HIS251
A	HIS251
B	LYS22
B	THR67
B	HIS251
C	LYS22
C	THR67
C	HIS251

---

site_id	SWS_FT_FI2
Number of Residues	40
Details	BINDING: BINDING => ECO:0000305|PubMed:18645230, ECO:0007744|PDB:2YZB, ECO:0007744|PDB:2YZC

Chain	Residue	Details
A	THR67
B	GLN223
C	THR67
C	ASP68
C	PHE163
C	ARG180
C	GLN223
D	THR67
D	ASP68
D	PHE163
D	ARG180
A	ASP68
D	GLN223
E	THR67
E	ASP68
E	PHE163
E	ARG180
E	GLN223
F	THR67
F	ASP68
F	PHE163
F	ARG180
A	PHE163
F	GLN223
G	THR67
G	ASP68
G	PHE163
G	ARG180
G	GLN223
H	THR67
H	ASP68
H	PHE163
H	ARG180
A	ARG180
H	GLN223
A	GLN223
B	THR67
B	ASP68
B	PHE163
B	ARG180

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q00511

Chain	Residue	Details
A	ASN249
B	ASN249
C	ASN249
D	ASN249
E	ASN249
F	ASN249
G	ASN249
H	ASN249

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1r51

Chain	Residue	Details
A	ARG180
A	GLN223

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1r51

Chain	Residue	Details
B	ARG180
B	GLN223

---

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1r51

Chain	Residue	Details
C	ARG180
C	GLN223

---

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1r51

Chain	Residue	Details
D	ARG180
D	GLN223

---

site_id	CSA5
Number of Residues	2
Details	Annotated By Reference To The Literature 1r51

Chain	Residue	Details
E	ARG180
E	GLN223

---

site_id	CSA6
Number of Residues	2
Details	Annotated By Reference To The Literature 1r51

Chain	Residue	Details
F	ARG180
F	GLN223

---

site_id	CSA7
Number of Residues	2
Details	Annotated By Reference To The Literature 1r51

Chain	Residue	Details
G	ARG180
G	GLN223

---

site_id	CSA8
Number of Residues	2
Details	Annotated By Reference To The Literature 1r51

Chain	Residue	Details
H	ARG180
H	GLN223

---