2YYM
Crystal structure of the mutant of HpaB (T198I, A276G, and R466H) complexed with FAD and 4-hydroxyphenylacetate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004497 | molecular_function | monooxygenase activity |
| A | 0010124 | biological_process | phenylacetate catabolic process |
| A | 0016627 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors |
| A | 0016712 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen |
| A | 0019439 | biological_process | obsolete aromatic compound catabolic process |
| A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| A | 0052881 | molecular_function | 4-hydroxyphenylacetate 3-monooxygenase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 600 |
| Chain | Residue |
| A | ILE73 |
| A | TYR130 |
| A | ARG131 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 601 |
| Chain | Residue |
| A | TRP336 |
| A | THR337 |
| A | ARG338 |
| A | GLU340 |
| A | HOH1241 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 602 |
| Chain | Residue |
| A | GLU260 |
| A | ARG261 |
| A | TYR132 |
| site_id | AC4 |
| Number of Residues | 32 |
| Details | BINDING SITE FOR RESIDUE FAD A 500 |
| Chain | Residue |
| A | ARG100 |
| A | HIS142 |
| A | ALA143 |
| A | LEU144 |
| A | GLN148 |
| A | ARG151 |
| A | THR183 |
| A | THR185 |
| A | ALA312 |
| A | TYR315 |
| A | HIS317 |
| A | GLN378 |
| A | ILE379 |
| A | ALA381 |
| A | SER382 |
| A | ARG433 |
| A | LEU436 |
| A | TYR437 |
| A | PHE440 |
| A | PHE441 |
| A | GLY443 |
| A | ASP444 |
| A | ARG447 |
| A | 4HP550 |
| A | HOH1015 |
| A | HOH1037 |
| A | HOH1049 |
| A | HOH1067 |
| A | HOH1104 |
| A | HOH1143 |
| A | HOH1201 |
| A | HOH1441 |
| site_id | AC5 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE 4HP A 550 |
| Chain | Residue |
| A | ARG100 |
| A | TYR104 |
| A | HIS142 |
| A | LEU144 |
| A | SER197 |
| A | ILE198 |
| A | LEU199 |
| A | PHE441 |
| A | PHE442 |
| A | FAD500 |
| A | HOH1067 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | ARG100 | |
| A | SER197 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:17804419 |
| Chain | Residue | Details |
| A | HIS142 | |
| A | GLN148 | |
| A | THR185 | |
| A | ASP444 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1u8v |
| Chain | Residue | Details |
| A | MET284 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1u8v |
| Chain | Residue | Details |
| A | ASN282 |
