2YXN

Structual basis of azido-tyrosine recognition by engineered bacterial Tyrosyl-tRNA synthetase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004812	molecular_function	aminoacyl-tRNA ligase activity
A	0004831	molecular_function	tyrosine-tRNA ligase activity
A	0005524	molecular_function	ATP binding
A	0006418	biological_process	tRNA aminoacylation for protein translation
A	0006437	biological_process	tyrosyl-tRNA aminoacylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE AZY A 501

Chain	Residue
A	GLY39
A	HOH519
A	HOH561
A	HOH571
A	HOH728
A	HOH795
A	ASP41
A	LEU71
A	ASP81
A	TYR175
A	GLN179
A	ASP182
A	CYS195
A	GLN201

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Functional Information from PROSITE/UniProt

site_id	PS00178
Number of Residues	11
Details	AA_TRNA_LIGASE_I Aminoacyl-transfer RNA synthetases class-I signature. Pt.ADsLHLGHL

Chain	Residue	Details
A	PRO42-LEU52

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_02006, ECO:0000269|PubMed:15663931, ECO:0000305|PubMed:15671170

Chain	Residue	Details
A	VAL37

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site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_02006, ECO:0000269|PubMed:15663931, ECO:0000269|PubMed:15671170, ECO:0000305|PubMed:20159998

Chain	Residue	Details
A	TYR175
A	GLN179

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site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_02006

Chain	Residue	Details
A	LYS238

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site_id	SWS_FT_FI4
Number of Residues	2
Details	SITE: Cross-linked with tRNA by periodate oxidation

Chain	Residue	Details
A	ALA231
A	LYS238

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site_id	SWS_FT_FI5
Number of Residues	1
Details	SITE: Cross-linked with tRNA by periodate oxidation; predominant

Chain	Residue	Details
A	LYS235

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site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:18723842

Chain	Residue	Details
A	LYS144

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1d2r

Chain	Residue	Details
A	LYS238
A	LYS235

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site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 1d2r

Chain	Residue	Details
A	LYS85
A	LYS238
A	LYS235
A	ARG89

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