2YWC

Crystal structure of GMP synthetase from Thermus thermophilus in complex with XMP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003921	molecular_function	GMP synthase activity
A	0003922	molecular_function	GMP synthase (glutamine-hydrolyzing) activity
A	0005524	molecular_function	ATP binding
A	0005829	cellular_component	cytosol
A	0006164	biological_process	purine nucleotide biosynthetic process
A	0006177	biological_process	GMP biosynthetic process
A	0016874	molecular_function	ligase activity
A	0046037	biological_process	GMP metabolic process
B	0000166	molecular_function	nucleotide binding
B	0003921	molecular_function	GMP synthase activity
B	0003922	molecular_function	GMP synthase (glutamine-hydrolyzing) activity
B	0005524	molecular_function	ATP binding
B	0005829	cellular_component	cytosol
B	0006164	biological_process	purine nucleotide biosynthetic process
B	0006177	biological_process	GMP biosynthetic process
B	0016874	molecular_function	ligase activity
B	0046037	biological_process	GMP metabolic process
C	0000166	molecular_function	nucleotide binding
C	0003921	molecular_function	GMP synthase activity
C	0003922	molecular_function	GMP synthase (glutamine-hydrolyzing) activity
C	0005524	molecular_function	ATP binding
C	0005829	cellular_component	cytosol
C	0006164	biological_process	purine nucleotide biosynthetic process
C	0006177	biological_process	GMP biosynthetic process
C	0016874	molecular_function	ligase activity
C	0046037	biological_process	GMP metabolic process
D	0000166	molecular_function	nucleotide binding
D	0003921	molecular_function	GMP synthase activity
D	0003922	molecular_function	GMP synthase (glutamine-hydrolyzing) activity
D	0005524	molecular_function	ATP binding
D	0005829	cellular_component	cytosol
D	0006164	biological_process	purine nucleotide biosynthetic process
D	0006177	biological_process	GMP biosynthetic process
D	0016874	molecular_function	ligase activity
D	0046037	biological_process	GMP metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE XMP A 701

Chain	Residue
A	ARG288
A	HOH773
A	HOH784
A	HOH807
A	PRO382
A	GLY383
A	PRO384
A	GLN424
A	LYS495
A	THR499
A	ILE500
A	GLU501

---

site_id	AC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE XMP B 702

Chain	Residue
B	ARG288
B	PRO382
B	GLY383
B	PRO384
B	GLN424
B	PHE458
B	LYS495
B	THR499
B	ILE500
B	GLU501
B	HOH748

---

site_id	AC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE XMP C 703

Chain	Residue
C	ARG288
C	PRO382
C	GLY383
C	PRO384
C	GLN424
C	PHE458
C	LYS495
C	THR499
C	ILE500
C	GLU501

---

site_id	AC4
Number of Residues	10
Details	BINDING SITE FOR RESIDUE XMP D 704

Chain	Residue
D	ARG288
D	PRO382
D	GLY383
D	PRO384
D	GLN424
D	PHE458
D	LYS495
D	THR499
D	ILE500
D	GLU501

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"HAMAP-Rule","id":"MF_00344","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Active site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00344","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00344","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1bxr

Chain	Residue	Details
A	HIS164
A	GLU166
A	CYS78

---

site_id	CSA10
Number of Residues	6
Details	Annotated By Reference To The Literature 1bxr

Chain	Residue	Details
B	ASP221
B	GLY51
B	HIS164
B	TYR79
B	GLU166
B	CYS78

---

site_id	CSA11
Number of Residues	6
Details	Annotated By Reference To The Literature 1bxr

Chain	Residue	Details
C	ASP221
C	GLY51
C	HIS164
C	TYR79
C	GLU166
C	CYS78

---

site_id	CSA12
Number of Residues	6
Details	Annotated By Reference To The Literature 1bxr

Chain	Residue	Details
D	ASP221
D	GLY51
D	HIS164
D	TYR79
D	GLU166
D	CYS78

---

site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 1bxr

Chain	Residue	Details
D	HIS164
D	GLU166
D	CYS78

---

site_id	CSA3
Number of Residues	3
Details	Annotated By Reference To The Literature 1bxr

Chain	Residue	Details
C	HIS164
C	GLU166
C	CYS78

---

site_id	CSA4
Number of Residues	3
Details	Annotated By Reference To The Literature 1bxr

Chain	Residue	Details
B	HIS164
B	GLU166
B	CYS78

---

site_id	CSA5
Number of Residues	2
Details	Annotated By Reference To The Literature 1bxr

Chain	Residue	Details
A	HIS164
A	CYS78

---

site_id	CSA6
Number of Residues	2
Details	Annotated By Reference To The Literature 1bxr

Chain	Residue	Details
B	HIS164
B	CYS78

---

site_id	CSA7
Number of Residues	2
Details	Annotated By Reference To The Literature 1bxr

Chain	Residue	Details
C	HIS164
C	CYS78

---

site_id	CSA8
Number of Residues	2
Details	Annotated By Reference To The Literature 1bxr

Chain	Residue	Details
D	HIS164
D	CYS78

---

site_id	CSA9
Number of Residues	6
Details	Annotated By Reference To The Literature 1bxr

Chain	Residue	Details
A	ASP221
A	GLY51
A	HIS164
A	TYR79
A	GLU166
A	CYS78

---