2YVK

Crystal structure of 5-methylthioribose 1-phosphate isomerase product complex from Bacillus subtilis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0009086	biological_process	methionine biosynthetic process
A	0016853	molecular_function	isomerase activity
A	0019284	biological_process	L-methionine salvage from S-adenosylmethionine
A	0019509	biological_process	L-methionine salvage from methylthioadenosine
A	0044237	biological_process	cellular metabolic process
A	0044249	biological_process	cellular biosynthetic process
A	0046523	molecular_function	S-methyl-5-thioribose-1-phosphate isomerase activity
B	0009086	biological_process	methionine biosynthetic process
B	0016853	molecular_function	isomerase activity
B	0019284	biological_process	L-methionine salvage from S-adenosylmethionine
B	0019509	biological_process	L-methionine salvage from methylthioadenosine
B	0044237	biological_process	cellular metabolic process
B	0044249	biological_process	cellular biosynthetic process
B	0046523	molecular_function	S-methyl-5-thioribose-1-phosphate isomerase activity
C	0009086	biological_process	methionine biosynthetic process
C	0016853	molecular_function	isomerase activity
C	0019284	biological_process	L-methionine salvage from S-adenosylmethionine
C	0019509	biological_process	L-methionine salvage from methylthioadenosine
C	0044237	biological_process	cellular metabolic process
C	0044249	biological_process	cellular biosynthetic process
C	0046523	molecular_function	S-methyl-5-thioribose-1-phosphate isomerase activity
D	0009086	biological_process	methionine biosynthetic process
D	0016853	molecular_function	isomerase activity
D	0019284	biological_process	L-methionine salvage from S-adenosylmethionine
D	0019509	biological_process	L-methionine salvage from methylthioadenosine
D	0044237	biological_process	cellular metabolic process
D	0044249	biological_process	cellular biosynthetic process
D	0046523	molecular_function	S-methyl-5-thioribose-1-phosphate isomerase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE MRU A 501

Chain	Residue
A	ARG51
A	ALA239
A	ASP240
A	ASN250
A	LYS251
A	PHE317
A	GLY52
A	ALA53
A	ARG94
A	CYS160
A	ALA162
A	ALA166
A	THR167
A	GLN199

---

site_id	AC2
Number of Residues	15
Details	BINDING SITE FOR RESIDUE MRU B 502

Chain	Residue
B	ARG51
B	GLY52
B	ALA53
B	PRO54
B	ILE56
B	ARG94
B	CYS160
B	ALA162
B	ALA166
B	GLN199
B	ALA239
B	ASP240
B	ASN250
B	LYS251
B	PHE317

---

site_id	AC3
Number of Residues	15
Details	BINDING SITE FOR RESIDUE MRU C 503

Chain	Residue
C	ARG51
C	GLY52
C	ALA53
C	ARG94
C	CYS160
C	ALA162
C	ALA166
C	THR167
C	THR172
C	GLN199
C	ALA239
C	ASP240
C	ASN250
C	LYS251
C	HOH533

---

site_id	AC4
Number of Residues	14
Details	BINDING SITE FOR RESIDUE MRU D 504

Chain	Residue
D	ARG51
D	GLY52
D	ALA53
D	PRO54
D	ARG94
D	CYS160
D	ALA162
D	ALA166
D	GLN199
D	ALA239
D	ASP240
D	ASN250
D	LYS251
D	PHE317

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton donor

Chain	Residue	Details
A	ASP240
B	ASP240
C	ASP240
D	ASP240

---

site_id	SWS_FT_FI2
Number of Residues	16
Details	BINDING:

Chain	Residue	Details
C	ARG51
C	ARG94
C	GLN199
C	ASN250
D	ARG51
D	ARG94
D	GLN199
D	ASN250
A	ARG51
A	ARG94
A	GLN199
A	ASN250
B	ARG51
B	ARG94
B	GLN199
B	ASN250

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	SITE: Transition state stabilizer

Chain	Residue	Details
A	CYS160
B	CYS160
C	CYS160
D	CYS160

---