2YT0

Solution structure of the chimera of the C-terminal tail peptide of APP and the C-terminal PID domain of Fe65L

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001540	molecular_function	amyloid-beta binding

Functional Information from PROSITE/UniProt

site_id	PS00320
Number of Residues	8
Details	APP_INTRA Amyloid precursor protein (APP) intracellular domain signature. GYENPTYK

Chain	Residue	Details
A	GLY25-LYS32

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	SITE: Cleavage; by a caspase => ECO:0000250|UniProtKB:P05067

Chain	Residue	Details
A	ASP8

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by CDK5 and MAPK10 and LRRK2 => ECO:0000269|PubMed:28720718

Chain	Residue	Details
A	THR12

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphotyrosine; by ABL1 => ECO:0000269|PubMed:11279131

Chain	Residue	Details
A	TYR26

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P08592

Chain	Residue	Details
A	LYS32

---