2YRQ
Solution structure of the tandem HMG box domain from Human High mobility group protein B1
Functional Information from GO Data
Functional Information from PROSITE/UniProt
| site_id | PS00353 |
| Number of Residues | 12 |
| Details | HMG_BOX_1 HMG box A DNA-binding domain signature. FSKKCsERWKTM |
| Chain | Residue | Details |
| A | PHE48-MET59 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 70 |
| Details | DNA_BIND: HMG box 1 => ECO:0000255|PROSITE-ProRule:PRU00267 |
| Chain | Residue | Details |
| A | PRO16-ILE86 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 68 |
| Details | DNA_BIND: HMG box 2 => ECO:0000255|PROSITE-ProRule:PRU00267 |
| Chain | Residue | Details |
| A | PRO102-ARG170 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P10103 |
| Chain | Residue | Details |
| A | MET8 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | SITE: Cleavage; by thrombin:thrombomodulin => ECO:0000250|UniProtKB:P10103 |
| Chain | Residue | Details |
| A | ARG17 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | SITE: Cleavage; by CASP1 => ECO:0000269|PubMed:24474694 |
| Chain | Residue | Details |
| A | ASP74 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P10103 |
| Chain | Residue | Details |
| A | LYS10 | |
| A | LYS14 | |
| A | LYS15 | |
| A | LYS19 | |
| A | LYS35 | |
| A | LYS36 | |
| A | LYS134 | |
| A | LYS135 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: Cysteine sulfonic acid (-SO3H); alternate => ECO:0000250|UniProtKB:P63159 |
| Chain | Residue | Details |
| A | CYS30 | |
| A | CYS52 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | LYS37 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER42 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 3 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P63158 |
| Chain | Residue | Details |
| A | LYS50 | |
| A | LYS97 | |
| A | LYS148 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648 |
| Chain | Residue | Details |
| A | SER107 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | MOD_RES: Cysteine sulfonic acid (-SO3H) => ECO:0000250|UniProtKB:P63159 |
| Chain | Residue | Details |
| A | CYS113 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 5 |
| Details | CROSSLNK: Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-?) => ECO:0000269|PubMed:29618516 |
| Chain | Residue | Details |
| A | LYS35 | |
| A | LYS50 | |
| A | LYS51 | |
| A | LYS75 |
