2YOO

Cholest-4-en-3-one bound structure of CYP142 from Mycobacterium smegmatis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004497	molecular_function	monooxygenase activity
A	0005506	molecular_function	iron ion binding
A	0006629	biological_process	lipid metabolic process
A	0006707	biological_process	cholesterol catabolic process
A	0008202	biological_process	steroid metabolic process
A	0008203	biological_process	cholesterol metabolic process
A	0008395	molecular_function	steroid hydroxylase activity
A	0016042	biological_process	lipid catabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
A	0020037	molecular_function	heme binding
A	0036199	molecular_function	cholest-4-en-3-one 26-monooxygenase activity
A	0046872	molecular_function	metal ion binding
B	0004497	molecular_function	monooxygenase activity
B	0005506	molecular_function	iron ion binding
B	0006629	biological_process	lipid metabolic process
B	0006707	biological_process	cholesterol catabolic process
B	0008202	biological_process	steroid metabolic process
B	0008203	biological_process	cholesterol metabolic process
B	0008395	molecular_function	steroid hydroxylase activity
B	0016042	biological_process	lipid catabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
B	0020037	molecular_function	heme binding
B	0036199	molecular_function	cholest-4-en-3-one 26-monooxygenase activity
B	0046872	molecular_function	metal ion binding
C	0004497	molecular_function	monooxygenase activity
C	0005506	molecular_function	iron ion binding
C	0006629	biological_process	lipid metabolic process
C	0006707	biological_process	cholesterol catabolic process
C	0008202	biological_process	steroid metabolic process
C	0008203	biological_process	cholesterol metabolic process
C	0008395	molecular_function	steroid hydroxylase activity
C	0016042	biological_process	lipid catabolic process
C	0016491	molecular_function	oxidoreductase activity
C	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
C	0020037	molecular_function	heme binding
C	0036199	molecular_function	cholest-4-en-3-one 26-monooxygenase activity
C	0046872	molecular_function	metal ion binding
D	0004497	molecular_function	monooxygenase activity
D	0005506	molecular_function	iron ion binding
D	0006629	biological_process	lipid metabolic process
D	0006707	biological_process	cholesterol catabolic process
D	0008202	biological_process	steroid metabolic process
D	0008203	biological_process	cholesterol metabolic process
D	0008395	molecular_function	steroid hydroxylase activity
D	0016042	biological_process	lipid catabolic process
D	0016491	molecular_function	oxidoreductase activity
D	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
D	0020037	molecular_function	heme binding
D	0036199	molecular_function	cholest-4-en-3-one 26-monooxygenase activity
D	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	25
Details	BINDING SITE FOR RESIDUE HEM A 1402

Chain	Residue
A	GLU56
A	THR238
A	THR241
A	LEU274
A	PRO279
A	VAL280
A	ARG285
A	ALA335
A	PHE336
A	GLY337
A	PHE338
A	ILE79
A	HIS341
A	CYS343
A	LEU344
A	GLY345
A	K2B1404
A	HOH2339
A	HIS86
A	ARG90
A	ILE141
A	ILE230
A	GLY233
A	GLY234
A	THR237

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K2B A 1404

Chain	Residue
A	GLN72
A	TYR77
A	MET179
A	PHE182
A	LEU229
A	HEM1402

---

site_id	AC3
Number of Residues	22
Details	BINDING SITE FOR RESIDUE HEM B 1402

Chain	Residue
B	GLU56
B	ILE79
B	HIS86
B	ARG90
B	PHE97
B	GLY233
B	GLY234
B	THR237
B	THR238
B	LEU274
B	VAL280
B	ARG285
B	ALA335
B	PHE336
B	GLY337
B	PHE338
B	HIS341
B	CYS343
B	GLY345
B	ALA349
B	K2B1404
B	HOH2371

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K2B B 1404

Chain	Residue
B	TYR77
B	MET179
B	PHE182
B	LEU229
B	HEM1402

---

site_id	AC5
Number of Residues	25
Details	BINDING SITE FOR RESIDUE HEM C 1402

Chain	Residue
C	GLU56
C	ILE79
C	HIS86
C	ARG90
C	ILE141
C	ILE230
C	GLY233
C	GLY234
C	THR237
C	THR238
C	THR241
C	LEU274
C	PRO279
C	VAL280
C	ARG285
C	ALA335
C	PHE336
C	GLY337
C	PHE338
C	HIS341
C	CYS343
C	LEU344
C	GLY345
C	K2B1404
C	HOH2395

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE K2B C 1404

Chain	Residue
C	TYR77
C	LEU178
C	PHE182
C	HEM1402

---

site_id	AC7
Number of Residues	28
Details	BINDING SITE FOR RESIDUE HEM D 1402

Chain	Residue
D	LEU274
D	PRO279
D	VAL280
D	MET283
D	ARG285
D	ALA335
D	PHE336
D	GLY337
D	PHE338
D	HIS341
D	CYS343
D	LEU344
D	GLY345
D	LEU348
D	K2B1404
D	HOH2347
D	GLU56
D	ILE79
D	HIS86
D	ARG90
D	PHE97
D	ILE141
D	ILE230
D	GLY233
D	GLY234
D	THR237
D	THR238
D	THR241

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K2B D 1404

Chain	Residue
D	TYR77
D	LEU178
D	MET179
D	PHE182
D	LEU229
D	HEM1402

---

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG B 1405

Chain	Residue
B	HOH2119
B	HOH2151
B	HOH2456
B	HOH2457
B	HOH2458
B	HOH2459

---

Functional Information from PROSITE/UniProt

site_id	PS00086
Number of Residues	10
Details	CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGfGTHFCLG

Chain	Residue	Details
A	PHE336-GLY345

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Binding site: {"description":"axial binding residue","evidences":[{"source":"PubMed","id":"23489718","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25210044","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2YOO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZBY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4TRI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UAX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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