Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2YOE

X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) in complex with GABA and flurazepam

Replaces: 4A96

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0006811	biological_process	monoatomic ion transport
E	0016020	cellular_component	membrane
E	0034220	biological_process	monoatomic ion transmembrane transport
F	0004888	molecular_function	transmembrane signaling receptor activity
F	0005216	molecular_function	monoatomic ion channel activity
F	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
F	0006811	biological_process	monoatomic ion transport
F	0016020	cellular_component	membrane
F	0034220	biological_process	monoatomic ion transmembrane transport
G	0004888	molecular_function	transmembrane signaling receptor activity
G	0005216	molecular_function	monoatomic ion channel activity
G	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
G	0006811	biological_process	monoatomic ion transport
G	0016020	cellular_component	membrane
G	0034220	biological_process	monoatomic ion transmembrane transport
H	0004888	molecular_function	transmembrane signaling receptor activity
H	0005216	molecular_function	monoatomic ion channel activity
H	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
H	0006811	biological_process	monoatomic ion transport
H	0016020	cellular_component	membrane
H	0034220	biological_process	monoatomic ion transmembrane transport
I	0004888	molecular_function	transmembrane signaling receptor activity
I	0005216	molecular_function	monoatomic ion channel activity
I	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
I	0006811	biological_process	monoatomic ion transport
I	0016020	cellular_component	membrane
I	0034220	biological_process	monoatomic ion transmembrane transport
J	0004888	molecular_function	transmembrane signaling receptor activity
J	0005216	molecular_function	monoatomic ion channel activity
J	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
J	0006811	biological_process	monoatomic ion transport
J	0016020	cellular_component	membrane
J	0034220	biological_process	monoatomic ion transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ABU B 1318

Chain	Residue
B	GLU131
B	PRO132
B	PHE133

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE FL7 C 1318

Chain	Residue
C	LEU76
C	THR87
B	THR87
B	GLY88
B	ASN89
C	ILE39
C	PRO74
C	ALA75

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ABU I 1318

Chain	Residue
H	PHE19
H	TYR38
I	GLU77
I	PHE133

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	600
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
C	THR234-PRO254
C	MET265-HIS285
D	LEU205-LEU225
D	THR234-PRO254
D	MET265-HIS285
E	LEU205-LEU225
E	THR234-PRO254
E	MET265-HIS285
F	LEU205-LEU225
F	THR234-PRO254
F	MET265-HIS285
G	LEU205-LEU225
I	MET265-HIS285
J	LEU205-LEU225
J	THR234-PRO254
J	MET265-HIS285
A	LEU205-LEU225
A	THR234-PRO254
A	MET265-HIS285
B	LEU205-LEU225
B	THR234-PRO254
B	MET265-HIS285
C	LEU205-LEU225
G	THR234-PRO254
G	MET265-HIS285
H	LEU205-LEU225
H	THR234-PRO254
H	MET265-HIS285
I	LEU205-LEU225
I	THR234-PRO254

site_id	SWS_FT_FI2
Number of Residues	220
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
C	GLU226-GLN233
C	ARG286-ARG301
D	GLU226-GLN233
D	ARG286-ARG301
E	GLU226-GLN233
E	ARG286-ARG301
F	GLU226-GLN233
F	ARG286-ARG301
G	GLU226-GLN233
I	ARG286-ARG301
J	GLU226-GLN233
J	ARG286-ARG301
A	GLU226-GLN233
A	ARG286-ARG301
B	GLU226-GLN233
B	ARG286-ARG301
G	ARG286-ARG301
H	GLU226-GLN233
H	ARG286-ARG301
I	GLU226-GLN233

site_id	SWS_FT_FI3
Number of Residues	90
Details	TOPO_DOM: Periplasmic => ECO:0000255

Chain	Residue	Details
C	ARG255-GLN264
D	ARG255-GLN264
E	ARG255-GLN264
F	ARG255-GLN264
J	ARG255-GLN264
A	ARG255-GLN264
B	ARG255-GLN264
G	ARG255-GLN264
H	ARG255-GLN264
I	ARG255-GLN264

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)