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2YNA

Crystal structure of the main protease of coronavirus HKU4

Functional Information from GO Data
ChainGOidnamespacecontents
A0008233molecular_functionpeptidase activity
A0019082biological_processviral protein processing
B0008233molecular_functionpeptidase activity
B0019082biological_processviral protein processing
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE NI A 1307
ChainResidue
ALEU27
AHIS41
ACYS148
AGLN306
AIMD1308

site_idAC2
Number of Residues3
DetailsBINDING SITE FOR RESIDUE NI B 1303
ChainResidue
BHIS41
BCYS148
BHOH2075

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE IMD A 1308
ChainResidue
AHIS41
AGLN306
ANI1307
ALEU27

site_idAC4
Number of Residues9
DetailsBINDING SITE FOR RESIDUE GOL B 1304
ChainResidue
ATHR126
AHOH2275
BALA8
BASP295
BHOH2014
BHOH2213
BHOH2214
BHOH2344
BHOH2345

site_idAC5
Number of Residues11
DetailsBINDING SITE FOR RESIDUE GOL A 1309
ChainResidue
AMET6
AALA8
AGLU155
AMET298
AHOH2014
AHOH2307
AHOH2308
AHOH2311
AHOH2466
AHOH2467
BTHR126

site_idAC6
Number of Residues8
DetailsBINDING SITE FOR RESIDUE GOL B 1305
ChainResidue
BSER107
BTHR108
BSER179
BASP181
BHOH2169
BHOH2171
BHOH2349
BHOH2351

site_idAC7
Number of Residues5
DetailsBINDING SITE FOR RESIDUE GOL B 1306
ChainResidue
AASN15
AHOH2023
BGLY11
BGLU14
BASN15

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsACT_SITE: For 3CL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00772
ChainResidueDetails
AHIS41
ACYS148
BHIS41
BCYS148

site_idSWS_FT_FI2
Number of Residues2
DetailsSITE: Cleavage; by 3CL-PRO => ECO:0000255
ChainResidueDetails
AGLN306
BGLN306

227111

PDB entries from 2024-11-06

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