2YHM

Structure of respiratory syncytial virus nucleocapsid protein, P212121 crystal form

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0005515	molecular_function	protein binding
A	0019013	cellular_component	viral nucleocapsid
A	0019028	cellular_component	viral capsid
A	0019029	cellular_component	helical viral capsid
A	0030291	molecular_function	protein serine/threonine kinase inhibitor activity
A	0030430	cellular_component	host cell cytoplasm
A	0039502	biological_process	symbiont-mediated suppression of host type I interferon-mediated signaling pathway
A	0039545	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity
A	0039554	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MDA-5 activity
A	0039580	biological_process	symbiont-mediated suppression of host PKR/eIFalpha signaling
A	0044423	cellular_component	virion component
A	0052170	biological_process	symbiont-mediated suppression of host innate immune response
A	0085034	biological_process	symbiont-mediated suppression of host NF-kappaB cascade
A	1990904	cellular_component	ribonucleoprotein complex
B	0003723	molecular_function	RNA binding
B	0005515	molecular_function	protein binding
B	0019013	cellular_component	viral nucleocapsid
B	0019028	cellular_component	viral capsid
B	0019029	cellular_component	helical viral capsid
B	0030291	molecular_function	protein serine/threonine kinase inhibitor activity
B	0030430	cellular_component	host cell cytoplasm
B	0039502	biological_process	symbiont-mediated suppression of host type I interferon-mediated signaling pathway
B	0039545	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity
B	0039554	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MDA-5 activity
B	0039580	biological_process	symbiont-mediated suppression of host PKR/eIFalpha signaling
B	0044423	cellular_component	virion component
B	0052170	biological_process	symbiont-mediated suppression of host innate immune response
B	0085034	biological_process	symbiont-mediated suppression of host NF-kappaB cascade
B	1990904	cellular_component	ribonucleoprotein complex
C	0003723	molecular_function	RNA binding
C	0005515	molecular_function	protein binding
C	0019013	cellular_component	viral nucleocapsid
C	0019028	cellular_component	viral capsid
C	0019029	cellular_component	helical viral capsid
C	0030291	molecular_function	protein serine/threonine kinase inhibitor activity
C	0030430	cellular_component	host cell cytoplasm
C	0039502	biological_process	symbiont-mediated suppression of host type I interferon-mediated signaling pathway
C	0039545	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity
C	0039554	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MDA-5 activity
C	0039580	biological_process	symbiont-mediated suppression of host PKR/eIFalpha signaling
C	0044423	cellular_component	virion component
C	0052170	biological_process	symbiont-mediated suppression of host innate immune response
C	0085034	biological_process	symbiont-mediated suppression of host NF-kappaB cascade
C	1990904	cellular_component	ribonucleoprotein complex
D	0003723	molecular_function	RNA binding
D	0005515	molecular_function	protein binding
D	0019013	cellular_component	viral nucleocapsid
D	0019028	cellular_component	viral capsid
D	0019029	cellular_component	helical viral capsid
D	0030291	molecular_function	protein serine/threonine kinase inhibitor activity
D	0030430	cellular_component	host cell cytoplasm
D	0039502	biological_process	symbiont-mediated suppression of host type I interferon-mediated signaling pathway
D	0039545	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity
D	0039554	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MDA-5 activity
D	0039580	biological_process	symbiont-mediated suppression of host PKR/eIFalpha signaling
D	0044423	cellular_component	virion component
D	0052170	biological_process	symbiont-mediated suppression of host innate immune response
D	0085034	biological_process	symbiont-mediated suppression of host NF-kappaB cascade
D	1990904	cellular_component	ribonucleoprotein complex
E	0003723	molecular_function	RNA binding
E	0005515	molecular_function	protein binding
E	0019013	cellular_component	viral nucleocapsid
E	0019028	cellular_component	viral capsid
E	0019029	cellular_component	helical viral capsid
E	0030291	molecular_function	protein serine/threonine kinase inhibitor activity
E	0030430	cellular_component	host cell cytoplasm
E	0039502	biological_process	symbiont-mediated suppression of host type I interferon-mediated signaling pathway
E	0039545	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity
E	0039554	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MDA-5 activity
E	0039580	biological_process	symbiont-mediated suppression of host PKR/eIFalpha signaling
E	0044423	cellular_component	virion component
E	0052170	biological_process	symbiont-mediated suppression of host innate immune response
E	0085034	biological_process	symbiont-mediated suppression of host NF-kappaB cascade
E	1990904	cellular_component	ribonucleoprotein complex
F	0003723	molecular_function	RNA binding
F	0005515	molecular_function	protein binding
F	0019013	cellular_component	viral nucleocapsid
F	0019028	cellular_component	viral capsid
F	0019029	cellular_component	helical viral capsid
F	0030291	molecular_function	protein serine/threonine kinase inhibitor activity
F	0030430	cellular_component	host cell cytoplasm
F	0039502	biological_process	symbiont-mediated suppression of host type I interferon-mediated signaling pathway
F	0039545	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity
F	0039554	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MDA-5 activity
F	0039580	biological_process	symbiont-mediated suppression of host PKR/eIFalpha signaling
F	0044423	cellular_component	virion component
F	0052170	biological_process	symbiont-mediated suppression of host innate immune response
F	0085034	biological_process	symbiont-mediated suppression of host NF-kappaB cascade
F	1990904	cellular_component	ribonucleoprotein complex
G	0003723	molecular_function	RNA binding
G	0005515	molecular_function	protein binding
G	0019013	cellular_component	viral nucleocapsid
G	0019028	cellular_component	viral capsid
G	0019029	cellular_component	helical viral capsid
G	0030291	molecular_function	protein serine/threonine kinase inhibitor activity
G	0030430	cellular_component	host cell cytoplasm
G	0039502	biological_process	symbiont-mediated suppression of host type I interferon-mediated signaling pathway
G	0039545	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity
G	0039554	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MDA-5 activity
G	0039580	biological_process	symbiont-mediated suppression of host PKR/eIFalpha signaling
G	0044423	cellular_component	virion component
G	0052170	biological_process	symbiont-mediated suppression of host innate immune response
G	0085034	biological_process	symbiont-mediated suppression of host NF-kappaB cascade
G	1990904	cellular_component	ribonucleoprotein complex
H	0003723	molecular_function	RNA binding
H	0005515	molecular_function	protein binding
H	0019013	cellular_component	viral nucleocapsid
H	0019028	cellular_component	viral capsid
H	0019029	cellular_component	helical viral capsid
H	0030291	molecular_function	protein serine/threonine kinase inhibitor activity
H	0030430	cellular_component	host cell cytoplasm
H	0039502	biological_process	symbiont-mediated suppression of host type I interferon-mediated signaling pathway
H	0039545	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity
H	0039554	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MDA-5 activity
H	0039580	biological_process	symbiont-mediated suppression of host PKR/eIFalpha signaling
H	0044423	cellular_component	virion component
H	0052170	biological_process	symbiont-mediated suppression of host innate immune response
H	0085034	biological_process	symbiont-mediated suppression of host NF-kappaB cascade
H	1990904	cellular_component	ribonucleoprotein complex
I	0003723	molecular_function	RNA binding
I	0005515	molecular_function	protein binding
I	0019013	cellular_component	viral nucleocapsid
I	0019028	cellular_component	viral capsid
I	0019029	cellular_component	helical viral capsid
I	0030291	molecular_function	protein serine/threonine kinase inhibitor activity
I	0030430	cellular_component	host cell cytoplasm
I	0039502	biological_process	symbiont-mediated suppression of host type I interferon-mediated signaling pathway
I	0039545	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity
I	0039554	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MDA-5 activity
I	0039580	biological_process	symbiont-mediated suppression of host PKR/eIFalpha signaling
I	0044423	cellular_component	virion component
I	0052170	biological_process	symbiont-mediated suppression of host innate immune response
I	0085034	biological_process	symbiont-mediated suppression of host NF-kappaB cascade
I	1990904	cellular_component	ribonucleoprotein complex
J	0003723	molecular_function	RNA binding
J	0005515	molecular_function	protein binding
J	0019013	cellular_component	viral nucleocapsid
J	0019028	cellular_component	viral capsid
J	0019029	cellular_component	helical viral capsid
J	0030291	molecular_function	protein serine/threonine kinase inhibitor activity
J	0030430	cellular_component	host cell cytoplasm
J	0039502	biological_process	symbiont-mediated suppression of host type I interferon-mediated signaling pathway
J	0039545	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity
J	0039554	biological_process	symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MDA-5 activity
J	0039580	biological_process	symbiont-mediated suppression of host PKR/eIFalpha signaling
J	0044423	cellular_component	virion component
J	0052170	biological_process	symbiont-mediated suppression of host innate immune response
J	0085034	biological_process	symbiont-mediated suppression of host NF-kappaB cascade
J	1990904	cellular_component	ribonucleoprotein complex

Functional Information from PROSITE/UniProt

site_id	PS00014
Number of Residues	4
Details	ER_TARGET Endoplasmic reticulum targeting sequence. AEEL

Chain	Residue	Details
A	ALA372-LEU375

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2210
Details	Region: {"description":"Interaction with the phosphoprotein","evidences":[{"source":"PubMed","id":"22623798","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	720
Details	Region: {"description":"Interaction with the phosphoprotein","evidences":[{"source":"UniProtKB","id":"P22677","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	10
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"22019509","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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