2YCA

Mixed-function P450 MycG in complex with mycinamicin III in P21212 space group

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004497	molecular_function	monooxygenase activity
A	0005506	molecular_function	iron ion binding
A	0016491	molecular_function	oxidoreductase activity
A	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
A	0017000	biological_process	antibiotic biosynthetic process
A	0020037	molecular_function	heme binding
A	0046872	molecular_function	metal ion binding
A	0055114	biological_process	obsolete oxidation-reduction process

Functional Information from PDB Data

site_id	AC1
Number of Residues	19
Details	BINDING SITE FOR RESIDUE HEM A 450

Chain	Residue
A	LEU84
A	ARG288
A	PHE339
A	GLY340
A	HIS344
A	CYS346
A	LEU347
A	GLY348
A	ZM3460
A	HOH2195
A	HOH2324
A	HIS91
A	ARG95
A	PHE102
A	ALA234
A	GLY235
A	SER238
A	THR239
A	PHE286

---

site_id	AC2
Number of Residues	15
Details	BINDING SITE FOR RESIDUE ZM3 A 460

Chain	Residue
A	LEU84
A	TYR187
A	VAL233
A	ALA234
A	GLU237
A	SER238
A	GLY281
A	THR284
A	THR311
A	HEM450
A	GOL1399
A	HOH2191
A	HOH2198
A	HOH2199
A	HOH2325

---

site_id	AC3
Number of Residues	12
Details	BINDING SITE FOR RESIDUE GOL A 1398

Chain	Residue
A	LEU56
A	GLY57
A	ASP58
A	GLY59
A	PHE61
A	PRO88
A	ASP325
A	GLY342
A	VAL343
A	HOH2093
A	HOH2264
A	HOH2266

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 1399

Chain	Residue
A	PRO72
A	ARG73
A	THR284
A	PRO287
A	LEU308
A	ZM3460
A	HOH2327

---

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 1400

Chain	Residue
A	ARG140
A	THR240
A	ALA244
A	GLY389
A	PRO390
A	LEU391
A	HOH2328

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SIN A 1401

Chain	Residue
A	ALA126
A	ARG366
A	LEU367
A	TRP397
A	HOH2306

---

Functional Information from PROSITE/UniProt

site_id	PS00086
Number of Residues	10
Details	CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGhGVHHCLG

Chain	Residue	Details
A	PHE339-GLY348

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	23
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	10
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22952225","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2Y46","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2Y98","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZSN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22952225","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Binding site: {"description":"axial binding residue","evidences":[{"source":"PubMed","id":"22952225","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2Y5N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2Y98","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2YCA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---