2YC1
Crystal structure of the human derived single chain antibody fragment (scFv) 9004G in complex with Cn2 toxin from the scorpion Centruroides noxius Hoffmann
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| C | 0005576 | cellular_component | extracellular region |
| C | 0006952 | biological_process | defense response |
| C | 0008200 | molecular_function | ion channel inhibitor activity |
| C | 0017080 | molecular_function | sodium channel regulator activity |
| C | 0019871 | molecular_function | sodium channel inhibitor activity |
| C | 0035821 | biological_process | modulation of process of another organism |
| C | 0090729 | molecular_function | toxin activity |
| C | 0099106 | molecular_function | ion channel regulator activity |
| F | 0005576 | cellular_component | extracellular region |
| F | 0006952 | biological_process | defense response |
| F | 0008200 | molecular_function | ion channel inhibitor activity |
| F | 0017080 | molecular_function | sodium channel regulator activity |
| F | 0019871 | molecular_function | sodium channel inhibitor activity |
| F | 0035821 | biological_process | modulation of process of another organism |
| F | 0090729 | molecular_function | toxin activity |
| F | 0099106 | molecular_function | ion channel regulator activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL C 1066 |
| Chain | Residue |
| B | SER160 |
| B | ARG162 |
| C | TYR33 |
| C | GLY34 |
| C | LYS35 |
| C | GOL1067 |
| C | GOL1068 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL C 1067 |
| Chain | Residue |
| B | ARG224 |
| B | HOH2029 |
| C | GOL1066 |
| B | SER160 |
| B | ARG162 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL E 1240 |
| Chain | Residue |
| E | SER160 |
| E | ARG162 |
| E | ARG224 |
| E | GOL1242 |
| E | HOH2024 |
| E | HOH2072 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL E 1241 |
| Chain | Residue |
| E | GLN169 |
| E | LYS171 |
| E | ARG177 |
| E | PRO191 |
| E | GLU213 |
| E | ASP214 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL E 1242 |
| Chain | Residue |
| E | SER160 |
| E | ARG162 |
| E | GOL1240 |
| F | TYR33 |
| F | GLY34 |
| F | LYS35 |
| F | GOL1066 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL C 1068 |
| Chain | Residue |
| C | TYR33 |
| C | GLY34 |
| C | LYS35 |
| C | GLY36 |
| C | HIS50 |
| C | LEU51 |
| C | TYR52 |
| C | GOL1066 |
| site_id | AC7 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL F 1066 |
| Chain | Residue |
| E | GOL1242 |
| F | TYR33 |
| F | GLY34 |
| F | LYS35 |
| F | GLY36 |
| F | ALA37 |
| F | HIS50 |
| F | LEU51 |
| F | TYR52 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL D 1118 |
| Chain | Residue |
| A | SER54 |
| C | ARG27 |
| D | SER17 |
| D | GLN82 |
| D | HOH2108 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 1118 |
| Chain | Residue |
| A | SER17 |
| A | GLN82 |
| A | HOH2131 |
| D | SER54 |
| F | ARG27 |
