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2YBO

The x-ray structure of the SAM-dependent uroporphyrinogen III methyltransferase NirE from Pseudomonas aeruginosa in complex with SAH

Functional Information from GO Data
ChainGOidnamespacecontents
A0004851molecular_functionuroporphyrin-III C-methyltransferase activity
A0006779biological_processporphyrin-containing compound biosynthetic process
A0008168molecular_functionmethyltransferase activity
A0019354biological_processsiroheme biosynthetic process
A0032259biological_processmethylation
Functional Information from PDB Data
site_idAC1
Number of Residues22
DetailsBINDING SITE FOR RESIDUE SAH A 1267
ChainResidue
APRO27
ACYS138
ATYR185
AMET186
AVAL212
AGLN214
AGLY215
AGLN217
APRO242
ATHR243
ALEU244
ALEU52
AHOH2022
AHOH2065
AHOH2195
AGLY103
AGLY104
AASP105
AILE108
APHE109
ATHR133
AALA134

Functional Information from PROSITE/UniProt
site_idPS00839
Number of Residues15
DetailsSUMT_1 Uroporphyrin-III C-methyltransferase signature 1. VGAGPGdpgLLTLRA
ChainResidueDetails
AVAL23-ALA37

site_idPS00840
Number of Residues34
DetailsSUMT_2 Uroporphyrin-III C-methyltransferase signature 2. VvrLkgGDpfiFGrgaeelerLleagvdCqVvPG
ChainResidueDetails
AVAL98-GLY131

223166

PDB entries from 2024-07-31

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