2YBB
Fitted model for bovine mitochondrial supercomplex I1III2IV1 by single particle cryo-EM (EMD-1876)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| 1 | 0005886 | cellular_component | plasma membrane |
| 1 | 0008137 | molecular_function | NADH dehydrogenase (ubiquinone) activity |
| 1 | 0010181 | molecular_function | FMN binding |
| 1 | 0045271 | cellular_component | respiratory chain complex I |
| 1 | 0046872 | molecular_function | metal ion binding |
| 1 | 0048038 | molecular_function | quinone binding |
| 1 | 0051287 | molecular_function | NAD binding |
| 1 | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
| 1 | 1902600 | biological_process | proton transmembrane transport |
| 2 | 0005886 | cellular_component | plasma membrane |
| 2 | 0016491 | molecular_function | oxidoreductase activity |
| 2 | 0045271 | cellular_component | respiratory chain complex I |
| 2 | 0046872 | molecular_function | metal ion binding |
| 2 | 0048038 | molecular_function | quinone binding |
| 2 | 0051537 | molecular_function | 2 iron, 2 sulfur cluster binding |
| 3 | 0005886 | cellular_component | plasma membrane |
| 3 | 0008137 | molecular_function | NADH dehydrogenase (ubiquinone) activity |
| 3 | 0016020 | cellular_component | membrane |
| 3 | 0016491 | molecular_function | oxidoreductase activity |
| 3 | 0016651 | molecular_function | oxidoreductase activity, acting on NAD(P)H |
| 3 | 0042773 | biological_process | ATP synthesis coupled electron transport |
| 3 | 0043546 | molecular_function | molybdopterin cofactor binding |
| 3 | 0046872 | molecular_function | metal ion binding |
| 3 | 0048038 | molecular_function | quinone binding |
| 3 | 0051536 | molecular_function | iron-sulfur cluster binding |
| 3 | 0051537 | molecular_function | 2 iron, 2 sulfur cluster binding |
| 3 | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
| 3 | 1902600 | biological_process | proton transmembrane transport |
| 4 | 0005886 | cellular_component | plasma membrane |
| 4 | 0016651 | molecular_function | oxidoreductase activity, acting on NAD(P)H |
| 4 | 0048038 | molecular_function | quinone binding |
| 4 | 0050136 | molecular_function | NADH:ubiquinone reductase (non-electrogenic) activity |
| 4 | 0051287 | molecular_function | NAD binding |
| 5 | 0005886 | cellular_component | plasma membrane |
| 5 | 0008137 | molecular_function | NADH dehydrogenase (ubiquinone) activity |
| 5 | 0016651 | molecular_function | oxidoreductase activity, acting on NAD(P)H |
| 5 | 0048038 | molecular_function | quinone binding |
| 5 | 0050136 | molecular_function | NADH:ubiquinone reductase (non-electrogenic) activity |
| 5 | 1902600 | biological_process | proton transmembrane transport |
| 6 | 0005506 | molecular_function | iron ion binding |
| 6 | 0005886 | cellular_component | plasma membrane |
| 6 | 0008137 | molecular_function | NADH dehydrogenase (ubiquinone) activity |
| 6 | 0046872 | molecular_function | metal ion binding |
| 6 | 0048038 | molecular_function | quinone binding |
| 6 | 0050136 | molecular_function | NADH:ubiquinone reductase (non-electrogenic) activity |
| 6 | 0051536 | molecular_function | iron-sulfur cluster binding |
| 6 | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
| 6 | 1902600 | biological_process | proton transmembrane transport |
| 7 | 0005886 | cellular_component | plasma membrane |
| 7 | 0008199 | molecular_function | ferric iron binding |
| 7 | 0016226 | biological_process | iron-sulfur cluster assembly |
| 7 | 0048038 | molecular_function | quinone binding |
| 8 | 0005506 | molecular_function | iron ion binding |
| 8 | 0005886 | cellular_component | plasma membrane |
| 8 | 0016020 | cellular_component | membrane |
| 8 | 0016651 | molecular_function | oxidoreductase activity, acting on NAD(P)H |
| 8 | 0046872 | molecular_function | metal ion binding |
| 8 | 0048038 | molecular_function | quinone binding |
| 8 | 0050136 | molecular_function | NADH:ubiquinone reductase (non-electrogenic) activity |
| 8 | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
| a | 0005739 | cellular_component | mitochondrion |
| a | 0005743 | cellular_component | mitochondrial inner membrane |
| a | 0046872 | molecular_function | metal ion binding |
| a | 0070469 | cellular_component | respirasome |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005743 | cellular_component | mitochondrial inner membrane |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0070469 | cellular_component | respirasome |
| b | 0004222 | molecular_function | metalloendopeptidase activity |
| b | 0005739 | cellular_component | mitochondrion |
| b | 0005743 | cellular_component | mitochondrial inner membrane |
| b | 0006508 | biological_process | proteolysis |
| b | 0046872 | molecular_function | metal ion binding |
| b | 0070469 | cellular_component | respirasome |
| B | 0004222 | molecular_function | metalloendopeptidase activity |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005743 | cellular_component | mitochondrial inner membrane |
| B | 0006508 | biological_process | proteolysis |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0070469 | cellular_component | respirasome |
| c | 0005739 | cellular_component | mitochondrion |
| c | 0005743 | cellular_component | mitochondrial inner membrane |
| c | 0005750 | cellular_component | mitochondrial respiratory chain complex III |
| c | 0006122 | biological_process | mitochondrial electron transport, ubiquinol to cytochrome c |
| c | 0008121 | molecular_function | ubiquinol-cytochrome-c reductase activity |
| c | 0009055 | molecular_function | electron transfer activity |
| c | 0016020 | cellular_component | membrane |
| c | 0016491 | molecular_function | oxidoreductase activity |
| c | 0020037 | molecular_function | heme binding |
| c | 0022904 | biological_process | respiratory electron transport chain |
| c | 0031966 | cellular_component | mitochondrial membrane |
| c | 0045275 | cellular_component | respiratory chain complex III |
| c | 0046872 | molecular_function | metal ion binding |
| c | 0048039 | molecular_function | ubiquinone binding |
| c | 0070469 | cellular_component | respirasome |
| c | 1902600 | biological_process | proton transmembrane transport |
| C | 0005739 | cellular_component | mitochondrion |
| C | 0005743 | cellular_component | mitochondrial inner membrane |
| C | 0005750 | cellular_component | mitochondrial respiratory chain complex III |
| C | 0006122 | biological_process | mitochondrial electron transport, ubiquinol to cytochrome c |
| C | 0008121 | molecular_function | ubiquinol-cytochrome-c reductase activity |
| C | 0009055 | molecular_function | electron transfer activity |
| C | 0016020 | cellular_component | membrane |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0020037 | molecular_function | heme binding |
| C | 0022904 | biological_process | respiratory electron transport chain |
| C | 0031966 | cellular_component | mitochondrial membrane |
| C | 0045275 | cellular_component | respiratory chain complex III |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0048039 | molecular_function | ubiquinone binding |
| C | 0070469 | cellular_component | respirasome |
| C | 1902600 | biological_process | proton transmembrane transport |
| d | 0009055 | molecular_function | electron transfer activity |
| d | 0020037 | molecular_function | heme binding |
| D | 0009055 | molecular_function | electron transfer activity |
| D | 0020037 | molecular_function | heme binding |
| e | 0008121 | molecular_function | ubiquinol-cytochrome-c reductase activity |
| e | 0016020 | cellular_component | membrane |
| e | 0051537 | molecular_function | 2 iron, 2 sulfur cluster binding |
| E | 0008121 | molecular_function | ubiquinol-cytochrome-c reductase activity |
| E | 0016020 | cellular_component | membrane |
| E | 0051537 | molecular_function | 2 iron, 2 sulfur cluster binding |
| f | 0005739 | cellular_component | mitochondrion |
| f | 0005743 | cellular_component | mitochondrial inner membrane |
| f | 0005750 | cellular_component | mitochondrial respiratory chain complex III |
| f | 0006122 | biological_process | mitochondrial electron transport, ubiquinol to cytochrome c |
| f | 0070469 | cellular_component | respirasome |
| F | 0005739 | cellular_component | mitochondrion |
| F | 0005743 | cellular_component | mitochondrial inner membrane |
| F | 0005750 | cellular_component | mitochondrial respiratory chain complex III |
| F | 0006122 | biological_process | mitochondrial electron transport, ubiquinol to cytochrome c |
| F | 0070469 | cellular_component | respirasome |
| g | 0005739 | cellular_component | mitochondrion |
| g | 0005743 | cellular_component | mitochondrial inner membrane |
| g | 0005750 | cellular_component | mitochondrial respiratory chain complex III |
| g | 0006122 | biological_process | mitochondrial electron transport, ubiquinol to cytochrome c |
| g | 0070469 | cellular_component | respirasome |
| G | 0005739 | cellular_component | mitochondrion |
| G | 0005743 | cellular_component | mitochondrial inner membrane |
| G | 0005750 | cellular_component | mitochondrial respiratory chain complex III |
| G | 0006122 | biological_process | mitochondrial electron transport, ubiquinol to cytochrome c |
| G | 0070469 | cellular_component | respirasome |
| h | 0005750 | cellular_component | mitochondrial respiratory chain complex III |
| h | 0006122 | biological_process | mitochondrial electron transport, ubiquinol to cytochrome c |
| H | 0005750 | cellular_component | mitochondrial respiratory chain complex III |
| H | 0006122 | biological_process | mitochondrial electron transport, ubiquinol to cytochrome c |
| i | 0008121 | molecular_function | ubiquinol-cytochrome-c reductase activity |
| I | 0008121 | molecular_function | ubiquinol-cytochrome-c reductase activity |
| j | 0005739 | cellular_component | mitochondrion |
| j | 0005743 | cellular_component | mitochondrial inner membrane |
| j | 0005750 | cellular_component | mitochondrial respiratory chain complex III |
| j | 0006122 | biological_process | mitochondrial electron transport, ubiquinol to cytochrome c |
| j | 0070469 | cellular_component | respirasome |
| J | 0005739 | cellular_component | mitochondrion |
| J | 0005743 | cellular_component | mitochondrial inner membrane |
| J | 0005750 | cellular_component | mitochondrial respiratory chain complex III |
| J | 0006122 | biological_process | mitochondrial electron transport, ubiquinol to cytochrome c |
| J | 0070469 | cellular_component | respirasome |
| k | 0005739 | cellular_component | mitochondrion |
| k | 0005743 | cellular_component | mitochondrial inner membrane |
| k | 0005750 | cellular_component | mitochondrial respiratory chain complex III |
| k | 0006122 | biological_process | mitochondrial electron transport, ubiquinol to cytochrome c |
| k | 0070469 | cellular_component | respirasome |
| K | 0005739 | cellular_component | mitochondrion |
| K | 0005743 | cellular_component | mitochondrial inner membrane |
| K | 0005750 | cellular_component | mitochondrial respiratory chain complex III |
| K | 0006122 | biological_process | mitochondrial electron transport, ubiquinol to cytochrome c |
| K | 0070469 | cellular_component | respirasome |
| L | 0004129 | molecular_function | cytochrome-c oxidase activity |
| L | 0005739 | cellular_component | mitochondrion |
| L | 0005743 | cellular_component | mitochondrial inner membrane |
| L | 0005751 | cellular_component | mitochondrial respiratory chain complex IV |
| L | 0006119 | biological_process | oxidative phosphorylation |
| L | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| L | 0009060 | biological_process | aerobic respiration |
| L | 0015990 | biological_process | electron transport coupled proton transport |
| L | 0016020 | cellular_component | membrane |
| L | 0020037 | molecular_function | heme binding |
| L | 0045277 | cellular_component | respiratory chain complex IV |
| L | 0046872 | molecular_function | metal ion binding |
| L | 0070469 | cellular_component | respirasome |
| M | 0004129 | molecular_function | cytochrome-c oxidase activity |
| M | 0005507 | molecular_function | copper ion binding |
| M | 0005739 | cellular_component | mitochondrion |
| M | 0005743 | cellular_component | mitochondrial inner membrane |
| M | 0016020 | cellular_component | membrane |
| M | 0016491 | molecular_function | oxidoreductase activity |
| M | 0022900 | biological_process | electron transport chain |
| M | 0042773 | biological_process | ATP synthesis coupled electron transport |
| M | 0045277 | cellular_component | respiratory chain complex IV |
| M | 0046872 | molecular_function | metal ion binding |
| M | 0070469 | cellular_component | respirasome |
| M | 1902600 | biological_process | proton transmembrane transport |
| N | 0004129 | molecular_function | cytochrome-c oxidase activity |
| N | 0005739 | cellular_component | mitochondrion |
| N | 0005743 | cellular_component | mitochondrial inner membrane |
| N | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| N | 0008535 | biological_process | respiratory chain complex IV assembly |
| N | 0009055 | molecular_function | electron transfer activity |
| N | 0016020 | cellular_component | membrane |
| N | 0019646 | biological_process | aerobic electron transport chain |
| N | 0022904 | biological_process | respiratory electron transport chain |
| N | 0045277 | cellular_component | respiratory chain complex IV |
| N | 1902600 | biological_process | proton transmembrane transport |
| O | 0005751 | cellular_component | mitochondrial respiratory chain complex IV |
| O | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| P | 0005743 | cellular_component | mitochondrial inner membrane |
| P | 0005751 | cellular_component | mitochondrial respiratory chain complex IV |
| P | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| Q | 0005740 | cellular_component | mitochondrial envelope |
| Q | 0005751 | cellular_component | mitochondrial respiratory chain complex IV |
| Q | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| R | 0005743 | cellular_component | mitochondrial inner membrane |
| R | 0005751 | cellular_component | mitochondrial respiratory chain complex IV |
| S | 0005739 | cellular_component | mitochondrion |
| S | 0005743 | cellular_component | mitochondrial inner membrane |
| S | 0006119 | biological_process | oxidative phosphorylation |
| S | 0045277 | cellular_component | respiratory chain complex IV |
| T | 0005739 | cellular_component | mitochondrion |
| T | 0005743 | cellular_component | mitochondrial inner membrane |
| T | 0006119 | biological_process | oxidative phosphorylation |
| T | 0045277 | cellular_component | respiratory chain complex IV |
| U | 0005746 | cellular_component | mitochondrial respirasome |
| U | 0005751 | cellular_component | mitochondrial respiratory chain complex IV |
| U | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| V | 0005746 | cellular_component | mitochondrial respirasome |
| V | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| W | 0005751 | cellular_component | mitochondrial respiratory chain complex IV |
| W | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| X | 0005751 | cellular_component | mitochondrial respiratory chain complex IV |
| X | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| Y | 0005739 | cellular_component | mitochondrion |
| Y | 0005758 | cellular_component | mitochondrial intermembrane space |
| Y | 0006122 | biological_process | mitochondrial electron transport, ubiquinol to cytochrome c |
| Y | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| Y | 0006915 | biological_process | apoptotic process |
| Y | 0009055 | molecular_function | electron transfer activity |
| Y | 0020037 | molecular_function | heme binding |
| Y | 0046872 | molecular_function | metal ion binding |
| Y | 0070469 | cellular_component | respirasome |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SF4 1 439 |
| Chain | Residue |
| 1 | PRO199 |
| 1 | SER352 |
| 1 | CYS353 |
| 1 | LYS355 |
| 1 | CYS356 |
| 1 | CYS359 |
| 1 | SER398 |
| 1 | PHE399 |
| 1 | CYS400 |
| site_id | AC2 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE FMN 1 440 |
| Chain | Residue |
| 1 | GLY64 |
| 1 | ARG65 |
| 1 | GLY66 |
| 1 | LYS75 |
| 1 | ASN92 |
| 1 | ASP94 |
| 1 | SER96 |
| 1 | GLY183 |
| 1 | GLU184 |
| 1 | GLU185 |
| 1 | ILE218 |
| 1 | ASN219 |
| 1 | ASN220 |
| 1 | THR223 |
| 1 | PRO401 |
| 1 | NAI441 |
| site_id | AC3 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE NAI 1 441 |
| Chain | Residue |
| 1 | GLY66 |
| 1 | GLY67 |
| 1 | ALA68 |
| 1 | PHE70 |
| 1 | LYS75 |
| 1 | PHE78 |
| 1 | GLU97 |
| 1 | TYR180 |
| 1 | GLU185 |
| 1 | LYS202 |
| 1 | PHE205 |
| 1 | THR325 |
| 1 | PRO401 |
| 1 | FMN440 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE MG 1 442 |
| Chain | Residue |
| 1 | HIS35 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE FES 2 182 |
| Chain | Residue |
| 2 | CYS83 |
| 2 | SER87 |
| 2 | CYS88 |
| 2 | CYS124 |
| 2 | LEU125 |
| 2 | GLY126 |
| 2 | SER127 |
| 2 | CYS128 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG 2 206 |
| Chain | Residue |
| 1 | HIS350 |
| 2 | SER68 |
| 2 | GLU123 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SF4 3 784 |
| Chain | Residue |
| 3 | HIS115 |
| 3 | CYS119 |
| 3 | CYS122 |
| 3 | CYS128 |
| 3 | LEU130 |
| 3 | VAL232 |
| 3 | GLY233 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SF4 3 785 |
| Chain | Residue |
| 3 | CYS181 |
| 3 | ILE182 |
| 3 | CYS184 |
| 3 | ARG186 |
| 3 | CYS187 |
| 3 | CYS230 |
| 3 | VAL232 |
| 3 | ALA234 |
| site_id | AC9 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SF4 3 786 |
| Chain | Residue |
| 3 | CYS256 |
| 3 | CYS259 |
| 3 | VAL261 |
| 3 | GLY262 |
| 3 | CYS263 |
| 3 | ILE290 |
| 3 | CYS291 |
| 3 | PRO407 |
| 3 | ILE408 |
| site_id | BC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE FES 3 787 |
| Chain | Residue |
| 3 | CYS34 |
| 3 | SER35 |
| 3 | GLY43 |
| 3 | ALA44 |
| 3 | CYS45 |
| 3 | ARG46 |
| 3 | CYS48 |
| 3 | CYS83 |
| site_id | BC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MG 3 788 |
| Chain | Residue |
| 3 | LEU274 |
| 3 | ASP302 |
| site_id | BC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MG 3 789 |
| Chain | Residue |
| 3 | HIS167 |
| 7 | GLU32 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG 4 410 |
| Chain | Residue |
| 4 | VAL223 |
| 4 | ALA384 |
| 4 | LYS386 |
| 4 | GLU388 |
| site_id | BC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE MG 5 208 |
| Chain | Residue |
| 5 | HIS144 |
| site_id | BC6 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SF4 6 182 |
| Chain | Residue |
| 6 | CYS111 |
| 6 | CYS140 |
| 6 | PRO141 |
| 4 | ARG84 |
| 4 | HIS169 |
| 6 | CYS45 |
| 6 | CYS46 |
| 6 | GLY82 |
| 6 | ARG83 |
| 6 | ALA110 |
| site_id | BC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA 7 204 |
| Chain | Residue |
| 3 | ASP165 |
| 3 | HIS168 |
| 7 | GLU32 |
| 7 | GLU34 |
| 7 | SER60 |
| 7 | GLY64 |
| site_id | BC8 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SF4 8 183 |
| Chain | Residue |
| 8 | HIS41 |
| 8 | CYS63 |
| 8 | ILE68 |
| 8 | CYS98 |
| 8 | ILE99 |
| 8 | PHE100 |
| 8 | CYS101 |
| 8 | GLY102 |
| 8 | CYS104 |
| site_id | BC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SF4 8 184 |
| Chain | Residue |
| 8 | CYS53 |
| 8 | ILE54 |
| 8 | CYS56 |
| 8 | SER57 |
| 8 | CYS59 |
| 8 | CYS108 |
| 8 | THR110 |
| 8 | ALA112 |
| site_id | CC1 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE HEM C 501 |
| Chain | Residue |
| C | GLN44 |
| C | GLY48 |
| C | LEU49 |
| C | LEU51 |
| C | ARG80 |
| C | HIS83 |
| C | PHE90 |
| C | ALA127 |
| C | GLY130 |
| C | TYR131 |
| C | HIS182 |
| C | PHE183 |
| C | PRO186 |
| C | HOH2077 |
| C | HOH2102 |
| site_id | CC2 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE HEM C 502 |
| Chain | Residue |
| C | TRP31 |
| C | GLY34 |
| C | LEU37 |
| C | HIS97 |
| C | ARG100 |
| C | SER106 |
| C | TRP113 |
| C | GLY116 |
| C | HIS196 |
| C | LEU197 |
| C | LEU200 |
| C | SER205 |
| C | ASN206 |
| C | UQ12002 |
| C | HOH2015 |
| C | HOH2038 |
| site_id | CC3 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE SMA C 2001 |
| Chain | Residue |
| C | LEU121 |
| C | MET129 |
| C | MET138 |
| C | GLY142 |
| C | VAL145 |
| C | ILE146 |
| C | PRO270 |
| C | GLU271 |
| C | PHE274 |
| C | TYR278 |
| C | HOH2052 |
| e | CYS160 |
| e | HIS161 |
| site_id | CC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE UQ1 C 2002 |
| Chain | Residue |
| C | LEU21 |
| C | SER35 |
| C | LEU197 |
| C | HIS201 |
| C | SER205 |
| C | PHE220 |
| C | ASP228 |
| C | HEM502 |
| C | HOH2044 |
| site_id | CC5 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE HEC D 501 |
| Chain | Residue |
| D | VAL36 |
| D | CYS37 |
| D | CYS40 |
| D | HIS41 |
| D | ASN105 |
| D | LEU109 |
| D | PRO110 |
| D | PRO111 |
| D | ILE116 |
| D | ARG120 |
| D | TYR126 |
| D | PHE153 |
| D | ILE158 |
| D | GLY159 |
| D | MET160 |
| D | PRO163 |
| D | ILE164 |
| D | HOH4040 |
| D | HOH4053 |
| D | HOH4094 |
| D | HOH4113 |
| site_id | CC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE FES E 501 |
| Chain | Residue |
| E | CYS139 |
| E | HIS141 |
| E | LEU142 |
| E | CYS144 |
| E | CYS158 |
| E | HIS161 |
| E | SER163 |
| site_id | CC7 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE CDL G 2003 |
| Chain | Residue |
| C | SER29 |
| C | LEU36 |
| C | LYS227 |
| C | LEU234 |
| C | LEU235 |
| D | TYR220 |
| D | LYS223 |
| D | ARG224 |
| D | LYS231 |
| F | MET70 |
| F | ARG71 |
| G | TYR29 |
| G | ILE34 |
| G | ASN36 |
| G | ARG40 |
| G | HOH1515 |
| G | CDL2004 |
| site_id | CC8 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE CDL G 2004 |
| Chain | Residue |
| C | SER28 |
| C | SER29 |
| C | TRP30 |
| C | PHE33 |
| C | HOH2094 |
| F | GLN72 |
| G | ARG40 |
| G | THR41 |
| G | HOH1045 |
| G | HOH1254 |
| G | CDL2003 |
| site_id | CC9 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE HEA L 515 |
| Chain | Residue |
| L | GLY27 |
| L | MET28 |
| L | SER34 |
| L | ILE37 |
| L | ARG38 |
| L | TYR54 |
| L | VAL58 |
| L | HIS61 |
| L | ALA62 |
| L | MET65 |
| L | ILE66 |
| L | VAL70 |
| L | GLY125 |
| L | TRP126 |
| L | TYR371 |
| L | PHE377 |
| L | HIS378 |
| L | SER382 |
| L | PHE425 |
| L | GLN428 |
| L | ARG438 |
| L | ARG439 |
| L | MET468 |
| site_id | DC1 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE HEA L 516 |
| Chain | Residue |
| L | TRP126 |
| L | TRP236 |
| L | VAL243 |
| L | TYR244 |
| L | HIS290 |
| L | HIS291 |
| L | THR309 |
| L | ALA313 |
| L | THR316 |
| L | GLY317 |
| L | GLY352 |
| L | LEU353 |
| L | GLY355 |
| L | ILE356 |
| L | LEU358 |
| L | ALA359 |
| L | ASP364 |
| L | HIS368 |
| L | HIS376 |
| L | PHE377 |
| L | VAL380 |
| L | ARG438 |
| site_id | DC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CU L 517 |
| Chain | Residue |
| L | HIS240 |
| L | HIS290 |
| L | HIS291 |
| site_id | DC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG L 518 |
| Chain | Residue |
| L | HIS368 |
| L | ASP369 |
| M | GLU198 |
| site_id | DC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CU M 228 |
| Chain | Residue |
| M | HIS161 |
| M | CYS196 |
| M | CYS200 |
| M | MET207 |
| M | CU229 |
| site_id | DC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CU M 229 |
| Chain | Residue |
| M | CYS196 |
| M | GLU198 |
| M | CYS200 |
| M | HIS204 |
| M | CU228 |
| site_id | DC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN Q 99 |
| Chain | Residue |
| Q | CYS60 |
| Q | CYS62 |
| Q | CYS82 |
| Q | CYS85 |
| site_id | DC7 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE HEM Y 500 |
| Chain | Residue |
| Y | LYS13 |
| Y | CYS14 |
| Y | GLN16 |
| Y | CYS17 |
| Y | HIS18 |
| Y | THR28 |
| Y | PRO30 |
| Y | THR40 |
| Y | GLY41 |
| Y | TYR48 |
| Y | THR49 |
| Y | ASN52 |
| Y | TRP59 |
| Y | TYR67 |
| Y | LEU68 |
| Y | THR78 |
| Y | LYS79 |
| Y | MET80 |
| Y | ILE81 |
| Y | PHE82 |
| Y | HOH205 |
| Y | HOH217 |
| Y | HOH225 |
| site_id | DC8 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE HEM c 501 |
| Chain | Residue |
| c | GLN44 |
| c | GLY48 |
| c | LEU49 |
| c | LEU51 |
| c | ARG80 |
| c | HIS83 |
| c | PHE90 |
| c | ALA127 |
| c | GLY130 |
| c | TYR131 |
| c | HIS182 |
| c | PHE183 |
| c | PRO186 |
| c | HOH3067 |
| c | HOH3108 |
| site_id | DC9 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE HEM c 502 |
| Chain | Residue |
| c | TRP31 |
| c | GLY34 |
| c | LEU37 |
| c | HIS97 |
| c | VAL98 |
| c | ARG100 |
| c | SER106 |
| c | THR112 |
| c | GLY116 |
| c | VAL117 |
| c | HIS196 |
| c | LEU200 |
| c | SER205 |
| c | ASN206 |
| c | UQ13002 |
| c | HOH3015 |
| c | HOH3033 |
| site_id | EC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE SMA c 3001 |
| Chain | Residue |
| E | CYS160 |
| E | HIS161 |
| c | LEU121 |
| c | MET129 |
| c | MET138 |
| c | GLY142 |
| c | VAL145 |
| c | ILE146 |
| c | PRO270 |
| c | GLU271 |
| c | PHE274 |
| c | TYR278 |
| c | HOH3090 |
| site_id | EC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE UQ1 c 3002 |
| Chain | Residue |
| c | LEU21 |
| c | SER35 |
| c | HIS201 |
| c | SER205 |
| c | PHE220 |
| c | ASP228 |
| c | HEM502 |
| c | HOH3110 |
| c | HOH3116 |
| site_id | EC3 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE HEC d 501 |
| Chain | Residue |
| Y | HOH308 |
| d | VAL36 |
| d | CYS37 |
| d | CYS40 |
| d | HIS41 |
| d | ASN105 |
| d | LEU109 |
| d | PRO110 |
| d | PRO111 |
| d | ARG120 |
| d | TYR126 |
| d | PHE153 |
| d | ILE158 |
| d | GLY159 |
| d | MET160 |
| d | PRO163 |
| d | ILE164 |
| d | HOH3035 |
| d | HOH3047 |
| site_id | EC4 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE CDL d 3003 |
| Chain | Residue |
| c | SER29 |
| c | ASN32 |
| c | LEU36 |
| c | LYS227 |
| c | LEU234 |
| c | ALA238 |
| d | TYR220 |
| d | LYS223 |
| d | ARG224 |
| d | LYS231 |
| d | HOH3091 |
| f | MET70 |
| f | ARG71 |
| f | GLN72 |
| g | TYR29 |
| g | ILE34 |
| g | ASN36 |
| g | ARG40 |
| g | CDL3004 |
| site_id | EC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE FES e 501 |
| Chain | Residue |
| e | CYS139 |
| e | HIS141 |
| e | LEU142 |
| e | CYS144 |
| e | CYS158 |
| e | HIS161 |
| e | SER163 |
| site_id | EC6 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE CDL g 3004 |
| Chain | Residue |
| c | SER28 |
| c | SER29 |
| c | TRP30 |
| d | CDL3003 |
| f | GLN72 |
| g | ARG40 |
| g | THR41 |
| g | HOH3016 |
| g | HOH3017 |
| g | HOH3026 |
Functional Information from PROSITE/UniProt
| site_id | PS00077 |
| Number of Residues | 56 |
| Details | COX1_CUB Heme-copper oxidase catalytic subunit, copper B binding region signature. WFFGHPeVyililpgfgmishivtyysgkkepfgymgmvwammsigflgfivwa.HH |
| Chain | Residue | Details |
| L | TRP236-HIS291 |
| site_id | PS00078 |
| Number of Residues | 49 |
| Details | COX2 CO II and nitrous oxide reductase dinuclear copper centers signature. VlHswavpslglktdaipgrlnqttlmssrpglyygq......CseiCgsnHsfM |
| Chain | Residue | Details |
| M | VAL159-MET207 |
| site_id | PS00143 |
| Number of Residues | 24 |
| Details | INSULINASE Insulinase family, zinc-binding region signature. GsryensnnlGtSHLLRLAsSlTT |
| Chain | Residue | Details |
| b | GLY54-THR77 |
| site_id | PS00198 |
| Number of Residues | 12 |
| Details | 4FE4S_FER_1 4Fe-4S ferredoxin-type iron-sulfur binding region signature. CiGCSlCAaACP |
| Chain | Residue | Details |
| 8 | CYS53-PRO64 | |
| 8 | CYS98-PRO109 |
| site_id | PS00535 |
| Number of Residues | 12 |
| Details | COMPLEX1_49K Respiratory chain NADH dehydrogenase 49 Kd subunit signature. LHTGfEKTmEhR |
| Chain | Residue | Details |
| 4 | LEU62-ARG73 |
| site_id | PS00542 |
| Number of Residues | 22 |
| Details | COMPLEX1_30K Respiratory chain NADH dehydrogenase 30 Kd subunit signature. EREvyDLFgivfegHpdlRkIL |
| Chain | Residue | Details |
| 5 | GLU115-LEU136 |
| site_id | PS00641 |
| Number of Residues | 18 |
| Details | COMPLEX1_75K_1 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 1. PlfCSekhlspiGaCRmC |
| Chain | Residue | Details |
| 3 | PRO31-CYS48 |
| site_id | PS00642 |
| Number of Residues | 13 |
| Details | COMPLEX1_75K_2 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 2. CPtCDkGGaCeLQ |
| Chain | Residue | Details |
| 3 | CYS119-GLN131 |
| site_id | PS00643 |
| Number of Residues | 11 |
| Details | COMPLEX1_75K_3 Respiratory-chain NADH dehydrogenase 75 Kd subunit signature 3. RCIhCkRCVrY |
| Chain | Residue | Details |
| 3 | ARG180-TYR190 |
| site_id | PS00644 |
| Number of Residues | 16 |
| Details | COMPLEX1_51K_1 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 1. GAGAYICGEETALMNS |
| Chain | Residue | Details |
| 1 | GLY176-SER191 |
| site_id | PS00645 |
| Number of Residues | 12 |
| Details | COMPLEX1_51K_2 Respiratory-chain NADH dehydrogenase 51 Kd subunit signature 2. ESCGkCtPCReG |
| Chain | Residue | Details |
| 1 | GLU351-GLY362 |
| site_id | PS00848 |
| Number of Residues | 23 |
| Details | COX5B_1 Cytochrome c oxidase subunit Vb, zinc binding region signature. VIWfwlhkgeaqrCpsCGthYKL |
| Chain | Residue | Details |
| Q | VAL69-LEU91 |
| site_id | PS01099 |
| Number of Residues | 19 |
| Details | COMPLEX1_24K Respiratory-chain NADH dehydrogenase 24 Kd subunit signature. DglFSvqkveCLGsChtAP |
| Chain | Residue | Details |
| 2 | ASP114-PRO132 |
| site_id | PS01150 |
| Number of Residues | 17 |
| Details | COMPLEX1_20K Respiratory-chain NADH dehydrogenase 20 Kd subunit signature. NvDSVVPVDVYvPgCPP |
| Chain | Residue | Details |
| 6 | ASN126-PRO142 |
| site_id | PS01329 |
| Number of Residues | 18 |
| Details | COX6A Cytochrome c oxidase subunit VIa signature. IRtKpFsWGDGnHTfFhN |
| Chain | Residue | Details |
| R | ILE55-ASN72 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | BINDING: covalent |
| Chain | Residue | Details |
| Y | CYS14 | |
| c | TRP77-VAL98 | |
| c | TRP113-LEU133 | |
| c | PHE178-LEU198 | |
| c | ILE226-ALA246 | |
| c | LEU288-HIS308 | |
| c | LEU320-GLY340 | |
| c | TYR347-PRO367 | |
| Y | CYS17 | |
| Q | CYS82 | |
| Q | CYS85 | |
| L | SER401-ASN406 | |
| L | LYS479-LYS514 | |
| C | LEU320-GLY340 | |
| C | TYR347-PRO367 | |
| c | PHE33-MET53 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: axial binding residue |
| Chain | Residue | Details |
| Y | HIS18 | |
| Y | MET80 | |
| Q | LYS90 | |
| f | LYS18 | |
| f | LYS82 | |
| f | LYS95 | |
| 1 | CYS359 | |
| 1 | CYS400 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylglycine => ECO:0000269|PubMed:5933874 |
| Chain | Residue | Details |
| Y | GLY1 | |
| N | LEU106-GLU128 | |
| N | ALA184-ASP190 | |
| N | TYR257-SER261 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:16866357 |
| Chain | Residue | Details |
| Y | TYR48 | |
| e | SER163 | |
| O | LYS38 | |
| E | CYS158 | |
| E | HIS161 | |
| E | SER163 | |
| e | CYS139 | |
| e | HIS141 | |
| e | CYS158 | |
| e | HIS161 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P62897 |
| Chain | Residue | Details |
| Y | LYS55 | |
| M | CYS196 | |
| M | GLU198 | |
| M | CYS200 | |
| M | HIS204 | |
| M | MET207 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P62897 |
| Chain | Residue | Details |
| Y | LYS72 | |
| O | SER36 | |
| L | VAL287-ASP298 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:18471988 |
| Chain | Residue | Details |
| Y | TYR97 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P62897 |
| Chain | Residue | Details |
| Y | LYS99 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=VII => ECO:0000269|PubMed:27605664 |
| Chain | Residue | Details |
| N | PHE233-ILE256 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 16 |
| Details | TRANSMEM: Helical; Name=VII => ECO:0000269|PubMed:27605664 |
| Chain | Residue | Details |
| L | TYR270-ILE286 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 28 |
| Details | TRANSMEM: Helical; Name=VIII => ECO:0000269|PubMed:27605664 |
| Chain | Residue | Details |
| L | VAL299-LEU327 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 7 |
| Details | TOPO_DOM: Mitochondrial matrix => ECO:0000269|PubMed:27605664 |
| Chain | Residue | Details |
| L | HIS328-SER335 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=IX => ECO:0000269|PubMed:27605664 |
| Chain | Residue | Details |
| L | PRO336-VAL357 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 24 |
| Details | TOPO_DOM: Mitochondrial intermembrane => ECO:0000269|PubMed:27605664 |
| Chain | Residue | Details |
| L | LEU358-THR370 | |
| L | SER434-ALA446 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 29 |
| Details | TRANSMEM: Helical; Name=X => ECO:0000269|PubMed:27605664 |
| Chain | Residue | Details |
| L | TYR371-PHE400 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 26 |
| Details | TRANSMEM: Helical; Name=XI => ECO:0000269|PubMed:27605664 |
| Chain | Residue | Details |
| L | ASP407-LEU433 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 31 |
| Details | TRANSMEM: Helical; Name=XII => ECO:0000269|PubMed:27605664 |
| Chain | Residue | Details |
| L | TYR447-SER478 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:27605664, ECO:0000305|PubMed:23537388 |
| Chain | Residue | Details |
| L | GLU40 | |
| L | GLY45 | |
| L | SER441 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 3 |
| Details | BINDING: axial binding residue => ECO:0000269|PubMed:20385840, ECO:0000269|PubMed:8638158 |
| Chain | Residue | Details |
| L | HIS61 | |
| L | HIS376 | |
| L | HIS378 |
| site_id | SWS_FT_FI20 |
| Number of Residues | 5 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:20385840, ECO:0000269|PubMed:8638158 |
| Chain | Residue | Details |
| L | HIS240 | |
| L | HIS290 | |
| L | HIS291 | |
| L | HIS368 | |
| L | ASP369 |
| site_id | SWS_FT_FI21 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000305 |
| Chain | Residue | Details |
| L | TYR244 |
| site_id | SWS_FT_FI22 |
| Number of Residues | 1 |
| Details | MOD_RES: N-formylmethionine => ECO:0000269|PubMed:2165784 |
| Chain | Residue | Details |
| L | MET1 |
| site_id | SWS_FT_FI23 |
| Number of Residues | 2 |
| Details | CROSSLNK: 1'-histidyl-3'-tyrosine (His-Tyr) => ECO:0000269|PubMed:10338009 |
| Chain | Residue | Details |
| L | HIS240 | |
| L | TYR244 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 14 |
| Details | M-CSA 124 |
| Chain | Residue | Details |
| L | HIS61 | metal ligand |
| L | HIS290 | metal ligand |
| L | HIS291 | metal ligand, proton acceptor, proton donor |
| L | THR316 | proton acceptor, proton donor, proton relay |
| L | LYS319 | proton acceptor, proton donor, proton relay |
| L | ARG438 | proton acceptor, proton donor, proton relay |
| L | ASP91 | proton acceptor, proton donor, proton relay |
| L | TRP126 | proton acceptor, proton donor, proton relay |
| L | SER156 | proton acceptor, proton donor, proton relay |
| L | SER157 | proton acceptor, proton donor, proton relay |
| L | HIS240 | covalently attached, electrostatic stabiliser, metal ligand, radical stabiliser |
| L | GLU242 | proton acceptor, proton donor, proton relay |
| L | TYR244 | covalently attached, hydrogen radical donor, proton acceptor, proton donor, proton relay, single electron acceptor |
| L | SER255 | proton acceptor, proton donor, proton relay |
