2YAY

The Crystal Structure of Leishmania major dUTPase in complex with substrate analogue dUpNpp

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004170	molecular_function	dUTP diphosphatase activity
A	0005654	cellular_component	nucleoplasm
A	0016787	molecular_function	hydrolase activity
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	25
Details	BINDING SITE FOR RESIDUE DUP A 1265

Chain	Residue
A	GLN21
A	TRP61
A	ASP79
A	HIS82
A	PHE83
A	LYS179
A	ASN183
A	ARG186
A	TYR191
A	LYS198
A	ASN206
A	LEU24
A	CA1266
A	CA1267
A	HOH2011
A	HOH2026
A	HOH2054
A	HOH2055
A	ASN25
A	ILE28
A	TRP41
A	GLU48
A	GLU51
A	LYS59
A	TRP60

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site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 1266

Chain	Residue
A	GLU48
A	GLU51
A	DUP1265
A	CA1267
A	HOH2011

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site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA A 1267

Chain	Residue
A	GLU48
A	GLU51
A	GLU76
A	ASP79
A	DUP1265
A	CA1266
A	HOH2026

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