2YAJ
CRYSTAL STRUCTURE OF GLYCYL RADICAL ENZYME with bound substrate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0016829 | molecular_function | lyase activity |
| A | 0043722 | molecular_function | 4-hydroxyphenylacetate decarboxylase activity |
| B | 0016829 | molecular_function | lyase activity |
| B | 0043722 | molecular_function | 4-hydroxyphenylacetate decarboxylase activity |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0051536 | molecular_function | iron-sulfur cluster binding |
| B | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0005829 | cellular_component | cytosol |
| C | 0016829 | molecular_function | lyase activity |
| C | 0043722 | molecular_function | 4-hydroxyphenylacetate decarboxylase activity |
| D | 0016829 | molecular_function | lyase activity |
| D | 0043722 | molecular_function | 4-hydroxyphenylacetate decarboxylase activity |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0051536 | molecular_function | iron-sulfur cluster binding |
| D | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SF4 B 87 |
| Chain | Residue |
| B | HIS3 |
| B | CYS6 |
| B | ASN8 |
| B | CYS19 |
| B | LEU21 |
| B | CYS36 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE SF4 B 88 |
| Chain | Residue |
| B | CYS48 |
| B | ASN50 |
| B | PHE51 |
| B | CYS62 |
| B | ALA77 |
| B | CYS80 |
| B | SER82 |
| B | TYR83 |
| A | TRP58 |
| A | ARG61 |
| B | CYS45 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SF4 D 87 |
| Chain | Residue |
| D | HIS3 |
| D | CYS6 |
| D | ASN8 |
| D | CYS19 |
| D | LEU21 |
| D | ALA35 |
| D | CYS36 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SF4 D 88 |
| Chain | Residue |
| C | TRP58 |
| C | ARG61 |
| D | CYS45 |
| D | CYS48 |
| D | ASN50 |
| D | CYS62 |
| D | ALA77 |
| D | CYS80 |
| D | SER82 |
| D | TYR83 |
| site_id | AC5 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE 4HP A 1898 |
| Chain | Residue |
| A | PHE214 |
| A | ARG223 |
| A | SER344 |
| A | GLY345 |
| A | VAL399 |
| A | LEU400 |
| A | PHE405 |
| A | GLY502 |
| A | CYS503 |
| A | GLU505 |
| A | GLY532 |
| A | HIS536 |
| A | PHE537 |
| A | GLU637 |
| A | ILE750 |
| site_id | AC6 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE 4HP C 1898 |
| Chain | Residue |
| C | PHE214 |
| C | ILE219 |
| C | ARG223 |
| C | SER344 |
| C | GLY345 |
| C | VAL399 |
| C | PHE405 |
| C | GLY502 |
| C | CYS503 |
| C | GLU505 |
| C | GLY532 |
| C | HIS536 |
| C | PHE537 |
| C | GLU637 |
Functional Information from PROSITE/UniProt
| site_id | PS00178 |
| Number of Residues | 11 |
| Details | AA_TRNA_LIGASE_I Aminoacyl-transfer RNA synthetases class-I signature. Pg.GAsPTCGTG |
| Chain | Residue | Details |
| A | PRO524-GLY534 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1470 |
| Details | Domain: {"description":"PFL","evidences":[{"source":"PROSITE-ProRule","id":"PRU00887","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 238 |
| Details | Domain: {"description":"Glycine radical","evidences":[{"source":"PROSITE-ProRule","id":"PRU00493","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Cysteine radical intermediate","evidences":[{"source":"PubMed","id":"21823587","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"21823587","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21823587","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2YAJ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Glycine radical","evidences":[{"source":"PROSITE-ProRule","id":"PRU00493","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"21823587","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21823587","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2Y8N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2YAJ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
