2YA2

Catalytic Module of the Multi-modular glycogen-degrading pneumococcal virulence factor SpuA in complex with an inhibitor.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
A	0005975	biological_process	carbohydrate metabolic process

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Nucleophile => ECO:0000269|PubMed:21565699

Chain	Residue	Details
A	ASP323

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site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Proton donor => ECO:0000269|PubMed:21565699

Chain	Residue	Details
A	GLU352

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:21565699, ECO:0007744|PDB:2YA0

Chain	Residue	Details
A	SER206
A	TYR208
A	ASP537

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:21565699, ECO:0007744|PDB:2YA1

Chain	Residue	Details
A	TYR212
A	PHE288
A	TRP354
A	ASP384
A	ARG387
A	TYR394
A	ASP441
A	LYS514

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site_id	SWS_FT_FI5
Number of Residues	5
Details	BINDING: BINDING => ECO:0000269|PubMed:21565699, ECO:0007744|PDB:2YA2

Chain	Residue	Details
A	MET373
A	THR376
A	ASP377
A	ASP427
A	ASP431

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site_id	SWS_FT_FI6
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:21565699, ECO:0007744|PDB:2YA1, ECO:0007744|PDB:2YA2

Chain	Residue	Details
A	ASP534

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site_id	SWS_FT_FI7
Number of Residues	1
Details	SITE: Transition state stabilizer => ECO:0000305|PubMed:21565699

Chain	Residue	Details
A	ASP440

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