2Y98

Structure of the mixed-function P450 MycG in complex with mycinamicin IV in P21212 space group

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004497	molecular_function	monooxygenase activity
A	0005506	molecular_function	iron ion binding
A	0016491	molecular_function	oxidoreductase activity
A	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
A	0017000	biological_process	antibiotic biosynthetic process
A	0020037	molecular_function	heme binding
A	0046872	molecular_function	metal ion binding
A	0055114	biological_process	obsolete oxidation-reduction process

Functional Information from PDB Data

site_id	AC1
Number of Residues	25
Details	BINDING SITE FOR RESIDUE HEM A 450

Chain	Residue
A	LEU83
A	SER238
A	THR239
A	GLN242
A	ALA285
A	PHE286
A	ARG288
A	GLY338
A	PHE339
A	GLY340
A	HIS344
A	LEU84
A	CYS346
A	GLY348
A	ALA352
A	MIV460
A	HOH2248
A	HOH2388
A	HIS91
A	ARG95
A	PHE102
A	ILE147
A	LEU231
A	ALA234
A	GLY235

---

site_id	AC2
Number of Residues	16
Details	BINDING SITE FOR RESIDUE MIV A 460

Chain	Residue
A	ARG75
A	GLU77
A	VAL79
A	GLY81
A	GLY82
A	LEU84
A	PHE168
A	SER170
A	VAL174
A	VAL233
A	ALA234
A	LEU386
A	HEM450
A	HOH2206
A	HOH2389
A	HOH2390

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 1398

Chain	Residue
A	ARG145
A	HIS158
A	HOH2156

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 1399

Chain	Residue
A	ARG48
A	LYS100
A	ARG297
A	HOH2391

---

site_id	AC5
Number of Residues	10
Details	BINDING SITE FOR RESIDUE SO4 A 1400

Chain	Residue
A	ALA20
A	GLY21
A	ARG22
A	ARG53
A	GLN335
A	HIS341
A	HOH2065
A	HOH2393
A	HOH2394
A	HOH2395

---

site_id	AC6
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL A 1401

Chain	Residue
A	LEU56
A	GLY57
A	GLY59
A	PRO88
A	ASP325
A	GLY342
A	VAL343
A	HOH2116
A	HOH2320
A	HOH2396

---

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 1402

Chain	Residue
A	ARG140
A	THR240
A	ALA244
A	GLY389
A	PRO390
A	LEU391
A	HOH2397

---

Functional Information from PROSITE/UniProt

site_id	PS00086
Number of Residues	10
Details	CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGhGVHHCLG

Chain	Residue	Details
A	PHE339-GLY348

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	23
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	10
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22952225","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2Y46","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2Y98","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ZSN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22952225","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Binding site: {"description":"axial binding residue","evidences":[{"source":"PubMed","id":"22952225","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2Y5N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2Y98","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2YCA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---