2Y96

Structure of human dual-specificity phosphatase 27

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004721	molecular_function	phosphoprotein phosphatase activity
A	0004722	molecular_function	protein serine/threonine phosphatase activity
A	0004725	molecular_function	protein tyrosine phosphatase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0006470	biological_process	protein dephosphorylation
A	0008138	molecular_function	protein tyrosine/serine/threonine phosphatase activity
A	0016311	biological_process	dephosphorylation
A	0017018	molecular_function	myosin phosphatase activity
A	0032991	cellular_component	protein-containing complex
A	0033549	molecular_function	MAP kinase phosphatase activity
A	0042593	biological_process	glucose homeostasis
A	0042692	biological_process	muscle cell differentiation
A	0042803	molecular_function	protein homodimerization activity
A	0043409	biological_process	negative regulation of MAPK cascade
A	0070373	biological_process	negative regulation of ERK1 and ERK2 cascade
B	0004721	molecular_function	phosphoprotein phosphatase activity
B	0004722	molecular_function	protein serine/threonine phosphatase activity
B	0004725	molecular_function	protein tyrosine phosphatase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0006470	biological_process	protein dephosphorylation
B	0008138	molecular_function	protein tyrosine/serine/threonine phosphatase activity
B	0016311	biological_process	dephosphorylation
B	0017018	molecular_function	myosin phosphatase activity
B	0032991	cellular_component	protein-containing complex
B	0033549	molecular_function	MAP kinase phosphatase activity
B	0042593	biological_process	glucose homeostasis
B	0042692	biological_process	muscle cell differentiation
B	0042803	molecular_function	protein homodimerization activity
B	0043409	biological_process	negative regulation of MAPK cascade
B	0070373	biological_process	negative regulation of ERK1 and ERK2 cascade

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE SO4 A 1207

Chain	Residue
A	ASP115
A	HOH2075
A	CYS147
A	VAL148
A	MET149
A	GLY150
A	ARG151
A	SER152
A	ARG153
A	HOH2037

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 1208

Chain	Residue
A	THR53
A	HIS54
A	VAL55

---

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 1209

Chain	Residue
A	ARG73
A	ARG102

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site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 1210

Chain	Residue
A	HIS109
A	PHE131
A	ARG134
A	GLN202
A	GLN203
A	HOH2048
A	HOH2050
A	HOH2072

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 1211

Chain	Residue
A	GLN51
A	ASN56
A	GLU57

---

site_id	AC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 B 1202

Chain	Residue
B	ASP115
B	CYS147
B	VAL148
B	MET149
B	GLY150
B	ARG151
B	SER152
B	ARG153

---

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 B 1203

Chain	Residue
B	VAL148
B	ARG153

---

Functional Information from PROSITE/UniProt

site_id	PS00383
Number of Residues	11
Details	TYR_PHOSPHATASE_1 Tyrosine specific protein phosphatases active site. VHCvmGrsRSA

Chain	Residue	Details
A	VAL145-ALA155

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Phosphocysteine intermediate => ECO:0000255|PROSITE-ProRule:PRU00160

Chain	Residue	Details
A	CYS147
B	CYS147

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000305

Chain	Residue	Details
A	HIS146
B	HIS146

---