2Y96
Structure of human dual-specificity phosphatase 27
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004721 | molecular_function | phosphoprotein phosphatase activity |
| A | 0004722 | molecular_function | protein serine/threonine phosphatase activity |
| A | 0004725 | molecular_function | protein tyrosine phosphatase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006470 | biological_process | protein dephosphorylation |
| A | 0008138 | molecular_function | protein tyrosine/serine/threonine phosphatase activity |
| A | 0016311 | biological_process | dephosphorylation |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016791 | molecular_function | phosphatase activity |
| A | 0032991 | cellular_component | protein-containing complex |
| A | 0033549 | molecular_function | MAP kinase phosphatase activity |
| A | 0042593 | biological_process | glucose homeostasis |
| A | 0042692 | biological_process | muscle cell differentiation |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0043409 | biological_process | negative regulation of MAPK cascade |
| A | 0070373 | biological_process | negative regulation of ERK1 and ERK2 cascade |
| B | 0004721 | molecular_function | phosphoprotein phosphatase activity |
| B | 0004722 | molecular_function | protein serine/threonine phosphatase activity |
| B | 0004725 | molecular_function | protein tyrosine phosphatase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006470 | biological_process | protein dephosphorylation |
| B | 0008138 | molecular_function | protein tyrosine/serine/threonine phosphatase activity |
| B | 0016311 | biological_process | dephosphorylation |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016791 | molecular_function | phosphatase activity |
| B | 0032991 | cellular_component | protein-containing complex |
| B | 0033549 | molecular_function | MAP kinase phosphatase activity |
| B | 0042593 | biological_process | glucose homeostasis |
| B | 0042692 | biological_process | muscle cell differentiation |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0043409 | biological_process | negative regulation of MAPK cascade |
| B | 0070373 | biological_process | negative regulation of ERK1 and ERK2 cascade |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1207 |
| Chain | Residue |
| A | ASP115 |
| A | HOH2075 |
| A | CYS147 |
| A | VAL148 |
| A | MET149 |
| A | GLY150 |
| A | ARG151 |
| A | SER152 |
| A | ARG153 |
| A | HOH2037 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1208 |
| Chain | Residue |
| A | THR53 |
| A | HIS54 |
| A | VAL55 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1209 |
| Chain | Residue |
| A | ARG73 |
| A | ARG102 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1210 |
| Chain | Residue |
| A | HIS109 |
| A | PHE131 |
| A | ARG134 |
| A | GLN202 |
| A | GLN203 |
| A | HOH2048 |
| A | HOH2050 |
| A | HOH2072 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1211 |
| Chain | Residue |
| A | GLN51 |
| A | ASN56 |
| A | GLU57 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1202 |
| Chain | Residue |
| B | ASP115 |
| B | CYS147 |
| B | VAL148 |
| B | MET149 |
| B | GLY150 |
| B | ARG151 |
| B | SER152 |
| B | ARG153 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1203 |
| Chain | Residue |
| B | VAL148 |
| B | ARG153 |
Functional Information from PROSITE/UniProt
| site_id | PS00383 |
| Number of Residues | 11 |
| Details | TYR_PHOSPHATASE_1 Tyrosine specific protein phosphatases active site. VHCvmGrsRSA |
| Chain | Residue | Details |
| A | VAL145-ALA155 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 148 |
| Details | Domain: {"description":"Tyrosine-protein phosphatase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00160","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Phosphocysteine intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00160","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
