Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2Y75

The Structure of CymR (YrzC) the Global Cysteine Regulator of B. subtilis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001046	molecular_function	core promoter sequence-specific DNA binding
A	0003677	molecular_function	DNA binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0005515	molecular_function	protein binding
A	0005829	cellular_component	cytosol
A	0006351	biological_process	DNA-templated transcription
A	0006355	biological_process	regulation of DNA-templated transcription
A	0032991	cellular_component	protein-containing complex
A	0032993	cellular_component	protein-DNA complex
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0051291	biological_process	protein heterooligomerization
B	0001046	molecular_function	core promoter sequence-specific DNA binding
B	0003677	molecular_function	DNA binding
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0005515	molecular_function	protein binding
B	0005829	cellular_component	cytosol
B	0006351	biological_process	DNA-templated transcription
B	0006355	biological_process	regulation of DNA-templated transcription
B	0032991	cellular_component	protein-containing complex
B	0032993	cellular_component	protein-DNA complex
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0051291	biological_process	protein heterooligomerization
C	0001046	molecular_function	core promoter sequence-specific DNA binding
C	0003677	molecular_function	DNA binding
C	0003700	molecular_function	DNA-binding transcription factor activity
C	0005515	molecular_function	protein binding
C	0005829	cellular_component	cytosol
C	0006351	biological_process	DNA-templated transcription
C	0006355	biological_process	regulation of DNA-templated transcription
C	0032991	cellular_component	protein-containing complex
C	0032993	cellular_component	protein-DNA complex
C	0042802	molecular_function	identical protein binding
C	0042803	molecular_function	protein homodimerization activity
C	0051291	biological_process	protein heterooligomerization
D	0001046	molecular_function	core promoter sequence-specific DNA binding
D	0003677	molecular_function	DNA binding
D	0003700	molecular_function	DNA-binding transcription factor activity
D	0005515	molecular_function	protein binding
D	0005829	cellular_component	cytosol
D	0006351	biological_process	DNA-templated transcription
D	0006355	biological_process	regulation of DNA-templated transcription
D	0032991	cellular_component	protein-containing complex
D	0032993	cellular_component	protein-DNA complex
D	0042802	molecular_function	identical protein binding
D	0042803	molecular_function	protein homodimerization activity
D	0051291	biological_process	protein heterooligomerization
E	0001046	molecular_function	core promoter sequence-specific DNA binding
E	0003677	molecular_function	DNA binding
E	0003700	molecular_function	DNA-binding transcription factor activity
E	0005515	molecular_function	protein binding
E	0005829	cellular_component	cytosol
E	0006351	biological_process	DNA-templated transcription
E	0006355	biological_process	regulation of DNA-templated transcription
E	0032991	cellular_component	protein-containing complex
E	0032993	cellular_component	protein-DNA complex
E	0042802	molecular_function	identical protein binding
E	0042803	molecular_function	protein homodimerization activity
E	0051291	biological_process	protein heterooligomerization
F	0001046	molecular_function	core promoter sequence-specific DNA binding
F	0003677	molecular_function	DNA binding
F	0003700	molecular_function	DNA-binding transcription factor activity
F	0005515	molecular_function	protein binding
F	0005829	cellular_component	cytosol
F	0006351	biological_process	DNA-templated transcription
F	0006355	biological_process	regulation of DNA-templated transcription
F	0032991	cellular_component	protein-containing complex
F	0032993	cellular_component	protein-DNA complex
F	0042802	molecular_function	identical protein binding
F	0042803	molecular_function	protein homodimerization activity
F	0051291	biological_process	protein heterooligomerization

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 1130

Chain	Residue
A	ARG51
A	LYS57
A	SER58
A	HOH2068
F	HOH2142

site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 A 1131

Chain	Residue
A	LYS113
A	HOH2131
A	HOH2132
A	HOH2133
C	HOH2029
A	ARG82
A	PRO87
A	ILE88
A	SER89

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 1132

Chain	Residue
A	LYS7
A	HOH2135
C	LYS7
E	LYS7

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 1129

Chain	Residue
B	ARG51
B	LYS57
B	SER58
B	HOH2076
B	HOH2168

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 B 1130

Chain	Residue
B	ARG82
B	PRO87
B	ILE88
B	LYS113
B	HOH2169
B	HOH2170

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 1131

Chain	Residue
A	SER118
B	GLY61
B	ALA62

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL B 1132

Chain	Residue
B	LEU29
B	HOH2048

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 1130

Chain	Residue
C	ARG51
C	LYS57
C	SER58
C	HOH2049

site_id	AC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 C 1131

Chain	Residue
C	ARG82
C	PRO87
C	ILE88
C	SER89
C	LYS113
C	HOH2105
C	HOH2106
C	HOH2109

site_id	BC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 D 1129

Chain	Residue
D	ARG51
D	LYS57
D	SER58
D	HOH2088
D	HOH2170
D	HOH2172
D	HOH2173

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 D 1130

Chain	Residue
B	ASN37
D	ARG82
D	PRO87
D	ILE88
D	LYS113
D	HOH2174

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL D 1131

Chain	Residue
D	SER28
D	LEU29
D	HOH2020
D	HOH2031
D	HOH2064

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 E 1130

Chain	Residue
E	ARG51
E	LYS57
E	SER58
E	HOH2123
E	HOH2124

site_id	BC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 E 1131

Chain	Residue
A	HOH2048
E	ARG82
E	PRO87
E	ILE88
E	SER89
E	LYS113
E	HOH2125

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 F 1130

Chain	Residue
F	ARG51
F	LYS57
F	SER58
F	HOH2149
F	HOH2150
F	HOH2151

site_id	BC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 F 1131

Chain	Residue
F	ARG82
F	PRO87
F	ILE88
F	ARG109
F	LYS113
F	HOH2152

site_id	BC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 F 1132

Chain	Residue
F	ARG60
F	GLY61
F	HOH2153
F	HOH2154

site_id	BC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL F 1133

Chain	Residue
F	SER28
F	LEU29
F	HOH2010
F	HOH2063

site_id	CC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 F 1134

Chain	Residue
F	HOH2155
F	HOH2157
B	LYS7
D	LYS7
F	LYS7

Functional Information from PROSITE/UniProt

site_id	PS01332
Number of Residues	19
Details	HTH_RRF2_1 Rrf2-type HTH domain signature. LrnaGLvkSirGayGGYvL

Chain	Residue	Details
A	LEU50-LEU68

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	138
Details	DNA binding: {"description":"H-T-H motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU00540","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	492
Details	Domain: {"description":"HTH rrf2-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00540","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)