2Y6T
Molecular Recognition of Chymotrypsin by the Serine Protease Inhibitor Ecotin from Yersinia pestis
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0006508 | biological_process | proteolysis |
| A | 0097180 | cellular_component | serine protease inhibitor complex |
| A | 0097655 | molecular_function | serpin family protein binding |
| B | 0004252 | molecular_function | serine-type endopeptidase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0006508 | biological_process | proteolysis |
| B | 0097180 | cellular_component | serine protease inhibitor complex |
| B | 0097655 | molecular_function | serpin family protein binding |
| C | 0004252 | molecular_function | serine-type endopeptidase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005576 | cellular_component | extracellular region |
| C | 0006508 | biological_process | proteolysis |
| C | 0097180 | cellular_component | serine protease inhibitor complex |
| C | 0097655 | molecular_function | serpin family protein binding |
| D | 0004252 | molecular_function | serine-type endopeptidase activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005576 | cellular_component | extracellular region |
| D | 0006508 | biological_process | proteolysis |
| D | 0097180 | cellular_component | serine protease inhibitor complex |
| D | 0097655 | molecular_function | serpin family protein binding |
| E | 0004867 | molecular_function | serine-type endopeptidase inhibitor activity |
| E | 0042597 | cellular_component | periplasmic space |
| F | 0004867 | molecular_function | serine-type endopeptidase inhibitor activity |
| F | 0042597 | cellular_component | periplasmic space |
| G | 0004867 | molecular_function | serine-type endopeptidase inhibitor activity |
| G | 0042597 | cellular_component | periplasmic space |
| H | 0004867 | molecular_function | serine-type endopeptidase inhibitor activity |
| H | 0042597 | cellular_component | periplasmic space |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1246 |
| Chain | Residue |
| A | LYS93 |
| A | ASN95 |
| F | ARG135 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1246 |
| Chain | Residue |
| B | LYS93 |
| B | ASN95 |
| E | ARG135 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 C 1246 |
| Chain | Residue |
| C | ASN100 |
| H | ARG135 |
| C | LYS93 |
| C | ASN95 |
| C | THR98 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 D 1246 |
| Chain | Residue |
| D | LYS93 |
| D | ASN95 |
| D | ASN100 |
| D | HOH2004 |
| G | ARG135 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | Active site: {"description":"Charge relay system"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Site: {"description":"Reactive bond","evidences":[{"source":"HAMAP-Rule","id":"MF_00706","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 5 |
| Details | M-CSA 387 |
| Chain | Residue | Details |
| A | HIS57 | electrostatic stabiliser, proton shuttle (general acid/base) |
| A | ASP102 | modifies pKa |
| A | GLY193 | electrostatic stabiliser |
| A | SER195 | covalent catalysis |
| A | GLY196 | electrostatic stabiliser |
| site_id | MCSA2 |
| Number of Residues | 5 |
| Details | M-CSA 387 |
| Chain | Residue | Details |
| B | HIS57 | electrostatic stabiliser, proton shuttle (general acid/base) |
| B | ASP102 | modifies pKa |
| B | GLY193 | electrostatic stabiliser |
| B | SER195 | covalent catalysis |
| B | GLY196 | electrostatic stabiliser |
| site_id | MCSA3 |
| Number of Residues | 5 |
| Details | M-CSA 387 |
| Chain | Residue | Details |
| C | HIS57 | electrostatic stabiliser, proton shuttle (general acid/base) |
| C | ASP102 | modifies pKa |
| C | GLY193 | electrostatic stabiliser |
| C | SER195 | covalent catalysis |
| C | GLY196 | electrostatic stabiliser |
| site_id | MCSA4 |
| Number of Residues | 5 |
| Details | M-CSA 387 |
| Chain | Residue | Details |
| D | HIS57 | electrostatic stabiliser, proton shuttle (general acid/base) |
| D | ASP102 | modifies pKa |
| D | GLY193 | electrostatic stabiliser |
| D | SER195 | covalent catalysis |
| D | GLY196 | electrostatic stabiliser |
