2Y6P
Evidence for a Two-Metal-Ion-Mechanism in the Kdo- Cytidylyltransferase KdsB
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0008690 | molecular_function | 3-deoxy-manno-octulosonate cytidylyltransferase activity |
| A | 0009103 | biological_process | lipopolysaccharide biosynthetic process |
| A | 0016779 | molecular_function | nucleotidyltransferase activity |
| A | 0033468 | biological_process | CMP-keto-3-deoxy-D-manno-octulosonic acid biosynthetic process |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0008690 | molecular_function | 3-deoxy-manno-octulosonate cytidylyltransferase activity |
| B | 0009103 | biological_process | lipopolysaccharide biosynthetic process |
| B | 0016779 | molecular_function | nucleotidyltransferase activity |
| B | 0033468 | biological_process | CMP-keto-3-deoxy-D-manno-octulosonic acid biosynthetic process |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0008690 | molecular_function | 3-deoxy-manno-octulosonate cytidylyltransferase activity |
| C | 0009103 | biological_process | lipopolysaccharide biosynthetic process |
| C | 0016779 | molecular_function | nucleotidyltransferase activity |
| C | 0033468 | biological_process | CMP-keto-3-deoxy-D-manno-octulosonic acid biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR RESIDUE CTP A 1233 |
| Chain | Residue |
| A | PRO8 |
| A | SER72 |
| A | GLY73 |
| A | ARG76 |
| A | GLY94 |
| A | ASP95 |
| A | ASP219 |
| A | MG1234 |
| A | MG1235 |
| A | HOH2014 |
| A | HOH2056 |
| A | ALA9 |
| A | HOH2058 |
| A | HOH2059 |
| A | HOH2060 |
| A | HOH2061 |
| B | LYS232 |
| B | ASN233 |
| B | HOH2104 |
| A | ARG10 |
| A | SER13 |
| A | THR14 |
| A | ARG15 |
| A | LYS19 |
| A | LEU70 |
| A | PRO71 |
| site_id | AC2 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR RESIDUE CTP B 1235 |
| Chain | Residue |
| B | PRO8 |
| B | ALA9 |
| B | ARG10 |
| B | SER13 |
| B | THR14 |
| B | ARG15 |
| B | LYS19 |
| B | LEU70 |
| B | PRO71 |
| B | SER72 |
| B | GLY73 |
| B | ARG76 |
| B | GLN93 |
| B | GLY94 |
| B | ASP95 |
| B | ASP219 |
| B | MG1236 |
| B | MG1237 |
| B | HOH2031 |
| B | HOH2106 |
| B | HOH2107 |
| B | HOH2108 |
| B | HOH2109 |
| B | HOH2110 |
| B | HOH2111 |
| B | HOH2112 |
| site_id | AC3 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE CTP C 1232 |
| Chain | Residue |
| C | PRO8 |
| C | ALA9 |
| C | ARG10 |
| C | SER13 |
| C | THR14 |
| C | ARG15 |
| C | LYS19 |
| C | LEU70 |
| C | PRO71 |
| C | SER72 |
| C | GLY73 |
| C | ARG76 |
| C | GLN93 |
| C | GLY94 |
| C | ASP95 |
| C | ASP219 |
| C | MG1233 |
| C | MG1234 |
| C | HOH2016 |
| C | HOH2017 |
| C | HOH2018 |
| C | HOH2019 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MG A 1234 |
| Chain | Residue |
| A | LYS19 |
| A | ASP95 |
| A | ASP219 |
| A | CTP1233 |
| A | HOH2014 |
| A | HOH2015 |
| A | HOH2056 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MG B 1236 |
| Chain | Residue |
| B | LYS19 |
| B | ASP95 |
| B | ASP219 |
| B | CTP1235 |
| B | HOH2031 |
| B | HOH2095 |
| B | HOH2108 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG C 1233 |
| Chain | Residue |
| C | ASP95 |
| C | ASP219 |
| C | CTP1232 |
| C | HOH2015 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG A 1235 |
| Chain | Residue |
| A | CTP1233 |
| A | HOH2061 |
| B | ASN233 |
| B | HOH2104 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG B 1237 |
| Chain | Residue |
| B | HOH2111 |
| B | CTP1235 |
| B | HOH2109 |
| B | HOH2110 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG C 1234 |
| Chain | Residue |
| C | CTP1232 |
| C | HOH2016 |
| C | HOH2017 |
| C | HOH2018 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE IPA C 1235 |
| Chain | Residue |
| C | SER74 |
| C | ASN91 |
| C | PHE180 |
| C | GLU195 |
| site_id | BC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IPA A 1236 |
| Chain | Residue |
| A | GLU195 |
| site_id | BC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE BME A 1237 |
| Chain | Residue |
| A | GLU126 |
| A | GLU129 |
| B | ARG2 |
| B | ASP87 |
| B | GLU112 |
| B | HOH2044 |
