2Y69

Bovine heart cytochrome c oxidase re-refined with molecular oxygen

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004129	molecular_function	cytochrome-c oxidase activity
A	0005743	cellular_component	mitochondrial inner membrane
A	0006119	biological_process	oxidative phosphorylation
A	0009060	biological_process	aerobic respiration
A	0016020	cellular_component	membrane
A	0020037	molecular_function	heme binding
A	0022904	biological_process	respiratory electron transport chain
A	0045277	cellular_component	respiratory chain complex IV
A	0046872	molecular_function	metal ion binding
A	1902600	biological_process	proton transmembrane transport
B	0004129	molecular_function	cytochrome-c oxidase activity
B	0005507	molecular_function	copper ion binding
B	0005739	cellular_component	mitochondrion
B	0005743	cellular_component	mitochondrial inner membrane
B	0016020	cellular_component	membrane
B	0016491	molecular_function	oxidoreductase activity
B	0017004	biological_process	cytochrome complex assembly
B	0022900	biological_process	electron transport chain
B	0022904	biological_process	respiratory electron transport chain
B	0031966	cellular_component	mitochondrial membrane
B	0042773	biological_process	ATP synthesis coupled electron transport
B	0045277	cellular_component	respiratory chain complex IV
B	0046872	molecular_function	metal ion binding
B	1902600	biological_process	proton transmembrane transport
C	0004129	molecular_function	cytochrome-c oxidase activity
C	0005739	cellular_component	mitochondrion
C	0005743	cellular_component	mitochondrial inner membrane
C	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
C	0008535	biological_process	respiratory chain complex IV assembly
C	0009055	molecular_function	electron transfer activity
C	0016020	cellular_component	membrane
C	0019646	biological_process	aerobic electron transport chain
C	0022904	biological_process	respiratory electron transport chain
C	0045277	cellular_component	respiratory chain complex IV
C	1902600	biological_process	proton transmembrane transport
D	0005743	cellular_component	mitochondrial inner membrane
D	0006119	biological_process	oxidative phosphorylation
D	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
D	0045277	cellular_component	respiratory chain complex IV
E	0004129	molecular_function	cytochrome-c oxidase activity
E	0005739	cellular_component	mitochondrion
E	0005743	cellular_component	mitochondrial inner membrane
E	0006119	biological_process	oxidative phosphorylation
E	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
E	0045277	cellular_component	respiratory chain complex IV
E	0046872	molecular_function	metal ion binding
E	1902600	biological_process	proton transmembrane transport
F	0005739	cellular_component	mitochondrion
F	0005740	cellular_component	mitochondrial envelope
F	0005743	cellular_component	mitochondrial inner membrane
F	0006119	biological_process	oxidative phosphorylation
F	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
F	0045277	cellular_component	respiratory chain complex IV
F	0046872	molecular_function	metal ion binding
G	0005743	cellular_component	mitochondrial inner membrane
G	0006119	biological_process	oxidative phosphorylation
G	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
G	0016491	molecular_function	oxidoreductase activity
G	0030234	molecular_function	enzyme regulator activity
G	0045277	cellular_component	respiratory chain complex IV
H	0005739	cellular_component	mitochondrion
H	0005743	cellular_component	mitochondrial inner membrane
H	0006119	biological_process	oxidative phosphorylation
H	0016020	cellular_component	membrane
H	0045277	cellular_component	respiratory chain complex IV
I	0005743	cellular_component	mitochondrial inner membrane
I	0006119	biological_process	oxidative phosphorylation
I	0016020	cellular_component	membrane
I	0045277	cellular_component	respiratory chain complex IV
J	0005739	cellular_component	mitochondrion
J	0005743	cellular_component	mitochondrial inner membrane
J	0006119	biological_process	oxidative phosphorylation
J	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
J	0016491	molecular_function	oxidoreductase activity
J	0030674	molecular_function	protein-macromolecule adaptor activity
J	0031966	cellular_component	mitochondrial membrane
J	0045277	cellular_component	respiratory chain complex IV
J	0097250	biological_process	mitochondrial respirasome assembly
J	0098803	cellular_component	respiratory chain complex
K	0005739	cellular_component	mitochondrion
K	0005743	cellular_component	mitochondrial inner membrane
K	0006119	biological_process	oxidative phosphorylation
K	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
K	0007417	biological_process	central nervous system development
K	0016020	cellular_component	membrane
K	0045277	cellular_component	respiratory chain complex IV
L	0005743	cellular_component	mitochondrial inner membrane
L	0006119	biological_process	oxidative phosphorylation
L	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
L	0045277	cellular_component	respiratory chain complex IV
M	0005739	cellular_component	mitochondrion
M	0005743	cellular_component	mitochondrial inner membrane
M	0006119	biological_process	oxidative phosphorylation
M	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
M	0045277	cellular_component	respiratory chain complex IV
N	0004129	molecular_function	cytochrome-c oxidase activity
N	0005743	cellular_component	mitochondrial inner membrane
N	0006119	biological_process	oxidative phosphorylation
N	0009060	biological_process	aerobic respiration
N	0016020	cellular_component	membrane
N	0020037	molecular_function	heme binding
N	0022904	biological_process	respiratory electron transport chain
N	0045277	cellular_component	respiratory chain complex IV
N	0046872	molecular_function	metal ion binding
N	1902600	biological_process	proton transmembrane transport
O	0004129	molecular_function	cytochrome-c oxidase activity
O	0005507	molecular_function	copper ion binding
O	0005739	cellular_component	mitochondrion
O	0005743	cellular_component	mitochondrial inner membrane
O	0016020	cellular_component	membrane
O	0016491	molecular_function	oxidoreductase activity
O	0017004	biological_process	cytochrome complex assembly
O	0022900	biological_process	electron transport chain
O	0022904	biological_process	respiratory electron transport chain
O	0031966	cellular_component	mitochondrial membrane
O	0042773	biological_process	ATP synthesis coupled electron transport
O	0045277	cellular_component	respiratory chain complex IV
O	0046872	molecular_function	metal ion binding
O	1902600	biological_process	proton transmembrane transport
P	0004129	molecular_function	cytochrome-c oxidase activity
P	0005739	cellular_component	mitochondrion
P	0005743	cellular_component	mitochondrial inner membrane
P	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
P	0008535	biological_process	respiratory chain complex IV assembly
P	0009055	molecular_function	electron transfer activity
P	0016020	cellular_component	membrane
P	0019646	biological_process	aerobic electron transport chain
P	0022904	biological_process	respiratory electron transport chain
P	0045277	cellular_component	respiratory chain complex IV
P	1902600	biological_process	proton transmembrane transport
Q	0005743	cellular_component	mitochondrial inner membrane
Q	0006119	biological_process	oxidative phosphorylation
Q	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
Q	0045277	cellular_component	respiratory chain complex IV
R	0004129	molecular_function	cytochrome-c oxidase activity
R	0005739	cellular_component	mitochondrion
R	0005743	cellular_component	mitochondrial inner membrane
R	0006119	biological_process	oxidative phosphorylation
R	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
R	0045277	cellular_component	respiratory chain complex IV
R	0046872	molecular_function	metal ion binding
R	1902600	biological_process	proton transmembrane transport
S	0005739	cellular_component	mitochondrion
S	0005740	cellular_component	mitochondrial envelope
S	0005743	cellular_component	mitochondrial inner membrane
S	0006119	biological_process	oxidative phosphorylation
S	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
S	0045277	cellular_component	respiratory chain complex IV
S	0046872	molecular_function	metal ion binding
T	0005743	cellular_component	mitochondrial inner membrane
T	0006119	biological_process	oxidative phosphorylation
T	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
T	0016491	molecular_function	oxidoreductase activity
T	0030234	molecular_function	enzyme regulator activity
T	0045277	cellular_component	respiratory chain complex IV
U	0005739	cellular_component	mitochondrion
U	0005743	cellular_component	mitochondrial inner membrane
U	0006119	biological_process	oxidative phosphorylation
U	0016020	cellular_component	membrane
U	0045277	cellular_component	respiratory chain complex IV
V	0005743	cellular_component	mitochondrial inner membrane
V	0006119	biological_process	oxidative phosphorylation
V	0016020	cellular_component	membrane
V	0045277	cellular_component	respiratory chain complex IV
W	0005739	cellular_component	mitochondrion
W	0005743	cellular_component	mitochondrial inner membrane
W	0006119	biological_process	oxidative phosphorylation
W	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
W	0016491	molecular_function	oxidoreductase activity
W	0030674	molecular_function	protein-macromolecule adaptor activity
W	0031966	cellular_component	mitochondrial membrane
W	0045277	cellular_component	respiratory chain complex IV
W	0097250	biological_process	mitochondrial respirasome assembly
W	0098803	cellular_component	respiratory chain complex
X	0005739	cellular_component	mitochondrion
X	0005743	cellular_component	mitochondrial inner membrane
X	0006119	biological_process	oxidative phosphorylation
X	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
X	0007417	biological_process	central nervous system development
X	0016020	cellular_component	membrane
X	0045277	cellular_component	respiratory chain complex IV
Y	0005743	cellular_component	mitochondrial inner membrane
Y	0006119	biological_process	oxidative phosphorylation
Y	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
Y	0045277	cellular_component	respiratory chain complex IV
Z	0005739	cellular_component	mitochondrion
Z	0005743	cellular_component	mitochondrial inner membrane
Z	0006119	biological_process	oxidative phosphorylation
Z	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
Z	0045277	cellular_component	respiratory chain complex IV

Functional Information from PDB Data

site_id	AC1
Number of Residues	33
Details	BINDING SITE FOR RESIDUE HEA A 515

Chain	Residue
A	MET28
A	MET65
A	ILE66
A	MET69
A	VAL70
A	ILE73
A	GLY125
A	TRP126
A	TYR371
A	PHE377
A	HIS378
A	THR31
A	SER382
A	VAL386
A	PHE393
A	MET417
A	PHE425
A	GLN428
A	ARG438
A	ARG439
A	TYR440
A	SER458
A	SER34
A	VAL465
A	MET468
A	HOH2083
A	HOH2110
A	ILE37
A	ARG38
A	TYR54
A	VAL58
A	HIS61
A	ALA62

---

site_id	AC2
Number of Residues	29
Details	BINDING SITE FOR RESIDUE HEA A 516

Chain	Residue
A	TRP126
A	TRP236
A	VAL243
A	TYR244
A	HIS290
A	HIS291
A	THR309
A	THR316
A	GLY317
A	PHE348
A	THR349
A	GLY352
A	LEU353
A	GLY355
A	ILE356
A	LEU358
A	ALA359
A	ASP364
A	HIS368
A	VAL373
A	HIS376
A	PHE377
A	VAL380
A	LEU381
A	ARG438
A	OXY1515
A	HOH2111
A	HOH2112
A	HOH2113

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CU A 517

Chain	Residue
A	HIS240
A	HIS290
A	HIS291
A	OXY1515

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE OXY A 1515

Chain	Residue
A	HIS240
A	VAL243
A	HIS291
A	HEA516
A	CU517

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 1516

Chain	Residue
A	HIS368
A	ASP369
B	GLU198
B	HOH2079
B	HOH2089
B	HOH2090

---

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CHD A 1517

Chain	Residue
A	HIS233
A	ASP300
A	THR301
A	TYR304
A	HOH2114
C	TRP99
C	HIS103

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CUA B 228

Chain	Residue
B	HIS161
B	CYS196
B	GLU198
B	CYS200
B	HIS204
B	MET207

---

site_id	AC8
Number of Residues	16
Details	BINDING SITE FOR RESIDUE PEK C 1262

Chain	Residue
G	TRP62
G	THR68
G	PHE69
G	PHE70
G	HIS71
G	ASN76
G	HOH2032
A	HIS151
A	VAL155
C	TYR181
C	TYR182
C	ALA184
C	PHE186
C	THR187
C	ILE188
C	PHE198

---

site_id	AC9
Number of Residues	16
Details	BINDING SITE FOR RESIDUE PGV C 1263

Chain	Residue
A	PHE94
A	PRO95
A	ARG96
A	MET97
A	MET100
A	HOH2020
C	HIS9
C	ALA24
C	ASN50
C	MET54
C	TRP57
C	TRP58
C	GLU64
C	HIS71
C	GLY82
C	HOH2040

---

site_id	BC1
Number of Residues	17
Details	BINDING SITE FOR RESIDUE PGV C 1264

Chain	Residue
C	TRP58
C	VAL61
C	SER65
C	THR66
C	PHE86
C	ILE210
C	PHE214
C	ARG221
C	HIS226
C	THR228
C	HIS231
C	PHE233
C	GLY234
C	HOH2080
C	HOH2085
F	HOH2011
F	HOH2017

---

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CHD C 1265

Chain	Residue
C	ARG156
C	PHE164
C	PHE219
J	PHE1

---

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN F 1097

Chain	Residue
F	CYS60
F	CYS62
F	CYS82
F	CYS85

---

site_id	BC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE CHD G 1085

Chain	Residue
G	ARG14
G	ARG17
G	GLY22
G	HOH2007
G	HOH2041
N	MET271
O	GLU62
O	THR63
O	HOH2025

---

site_id	BC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE DMU M 1044

Chain	Residue
D	TRP98
M	LEU27
M	LEU28
M	GLY31
M	TRP32
M	TYR35
M	HIS36

---

site_id	BC6
Number of Residues	27
Details	BINDING SITE FOR RESIDUE HEA N 515

Chain	Residue
N	GLY27
N	MET28
N	THR31
N	SER34
N	ILE37
N	ARG38
N	TYR54
N	VAL58
N	HIS61
N	ALA62
N	MET65
N	ILE66
N	VAL70
N	GLY125
N	TRP126
N	TYR371
N	PHE377
N	HIS378
N	SER382
N	PHE425
N	GLN428
N	ARG438
N	ARG439
N	TYR440
N	HOH2092
N	HOH2113
N	HOH2114

---

site_id	BC7
Number of Residues	30
Details	BINDING SITE FOR RESIDUE HEA N 516

Chain	Residue
N	TRP126
N	TRP236
N	VAL243
N	TYR244
N	HIS290
N	HIS291
N	THR309
N	ILE312
N	ALA313
N	THR316
N	GLY317
N	GLY352
N	LEU353
N	GLY355
N	ILE356
N	LEU358
N	ALA359
N	ASP364
N	HIS368
N	VAL373
N	HIS376
N	PHE377
N	VAL380
N	LEU381
N	ARG438
N	OXY1515
N	HOH2067
N	HOH2115
N	HOH2116
N	HOH2117

---

site_id	BC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CU N 517

Chain	Residue
N	HIS240
N	HIS290
N	HIS291
N	OXY1515

---

site_id	BC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE OXY N 1515

Chain	Residue
N	HIS240
N	VAL243
N	HIS291
N	HEA516
N	CU517

---

site_id	CC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG N 1516

Chain	Residue
N	HIS368
N	ASP369
N	HOH2076
O	GLU198
O	HOH2069
O	HOH2080

---

site_id	CC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CHD N 1517

Chain	Residue
N	HIS233
N	ASP300
N	THR301
N	TYR304
N	HOH2118
P	TRP99
P	HIS103

---

site_id	CC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CUA O 228

Chain	Residue
O	HIS161
O	CYS196
O	GLU198
O	CYS200
O	HIS204
O	MET207

---

site_id	CC4
Number of Residues	15
Details	BINDING SITE FOR RESIDUE PEK P 1262

Chain	Residue
N	LEU215
P	TYR181
P	TYR182
P	ALA184
P	PHE186
P	THR187
P	ILE188
P	PHE198
P	PGV1263
T	TRP62
T	THR68
T	PHE69
T	PHE70
T	HIS71
T	ASN76

---

site_id	CC5
Number of Residues	21
Details	BINDING SITE FOR RESIDUE PGV P 1263

Chain	Residue
N	PHE94
N	PRO95
N	ARG96
N	MET97
N	MET100
N	HIS151
N	LEU152
N	VAL155
P	HIS9
P	ALA24
P	ASN50
P	MET54
P	TRP57
P	TRP58
P	GLU64
P	HIS71
P	LEU79
P	GLY82
P	MET83
P	PEK1262
P	PGV1264

---

site_id	CC6
Number of Residues	16
Details	BINDING SITE FOR RESIDUE PGV P 1264

Chain	Residue
P	TRP58
P	VAL61
P	SER65
P	THR66
P	HIS207
P	ILE210
P	THR213
P	PHE214
P	ARG221
P	HIS226
P	PHE227
P	THR228
P	HIS231
P	PHE233
P	GLY234
P	PGV1263

---

site_id	CC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CHD P 1265

Chain	Residue
P	ARG156
P	PHE164
P	PHE219
W	PHE1

---

site_id	CC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN S 1097

Chain	Residue
S	CYS60
S	CYS62
S	CYS82
S	CYS85

---

site_id	CC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CHD T 1085

Chain	Residue
A	MET271
A	TRP275
B	GLU62
B	THR63
T	ARG14
T	ARG17
T	GLY22

---

site_id	DC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE DMU Z 1043

Chain	Residue
Q	TRP98
Q	TYR102
Z	LEU27
Z	LEU28
Z	GLY31
Z	TRP32
Z	TYR35

---

Functional Information from PROSITE/UniProt

site_id	PS00077
Number of Residues	56
Details	COX1_CUB Heme-copper oxidase catalytic subunit, copper B binding region signature. WFFGHPeVyililpgfgmishivtyysgkkepfgymgmvwammsigflgfivwa.HH

Chain	Residue	Details
A	TRP236-HIS291

---

site_id	PS01329
Number of Residues	18
Details	COX6A Cytochrome c oxidase subunit VIa signature. IRtKpFsWGDGnHTfFhN

Chain	Residue	Details
G	ILE55-ASN72

---

site_id	PS00078
Number of Residues	49
Details	COX2 CO II and nitrous oxide reductase dinuclear copper centers signature. VlHswavpslglktdaipgrlnqttlmssrpglyygq......CseiCgsnHsfM

Chain	Residue	Details
B	VAL159-MET207

---

site_id	PS00848
Number of Residues	23
Details	COX5B_1 Cytochrome c oxidase subunit Vb, zinc binding region signature. VIWfwlhkgeaqrCpsCGthYKL

Chain	Residue	Details
F	VAL69-LEU91

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	152
Details	Transmembrane: {"description":"Helical; Name=I","evidences":[{"source":"PubMed","id":"27605664","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	18
Details	Topological domain: {"description":"Mitochondrial intermembrane","evidences":[{"source":"PubMed","id":"27605664","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8638158","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	174
Details	Transmembrane: {"description":"Helical; Name=II","evidences":[{"source":"PubMed","id":"27605664","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	130
Details	Topological domain: {"description":"Mitochondrial matrix","evidences":[{"source":"PubMed","id":"2165784","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27605664","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	108
Details	Transmembrane: {"description":"Helical; Name=III","evidences":[{"source":"PubMed","id":"27605664","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	94
Details	Topological domain: {"description":"Mitochondrial intermembrane","evidences":[{"source":"PubMed","id":"2165784","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27605664","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	104
Details	Transmembrane: {"description":"Helical; Name=IV","evidences":[{"source":"PubMed","id":"27605664","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	112
Details	Transmembrane: {"description":"Helical; Name=V","evidences":[{"source":"PubMed","id":"27605664","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	130
Details	Transmembrane: {"description":"Helical; Name=VI","evidences":[{"source":"PubMed","id":"27605664","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	78
Details	Transmembrane: {"description":"Helical; Name=VII","evidences":[{"source":"PubMed","id":"27605664","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	56
Details	Transmembrane: {"description":"Helical; Name=VIII","evidences":[{"source":"PubMed","id":"27605664","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	138
Details	Topological domain: {"description":"Mitochondrial matrix","evidences":[{"source":"PubMed","id":"27605664","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	42
Details	Transmembrane: {"description":"Helical; Name=IX","evidences":[{"source":"PubMed","id":"27605664","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	545
Details	Topological domain: {"description":"Mitochondrial intermembrane","evidences":[{"source":"PubMed","id":"27605664","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	58
Details	Transmembrane: {"description":"Helical; Name=X","evidences":[{"source":"PubMed","id":"27605664","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	52
Details	Transmembrane: {"description":"Helical; Name=XI","evidences":[{"source":"PubMed","id":"27605664","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	62
Details	Transmembrane: {"description":"Helical; Name=XII","evidences":[{"source":"PubMed","id":"27605664","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27605664","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23537388","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	6
Details	Binding site: {"description":"axial binding residue","evidences":[{"source":"PubMed","id":"20385840","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8638158","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	22
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20385840","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8638158","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	2
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	4
Details	Cross-link: {"description":"1'-histidyl-3'-tyrosine (His-Tyr)","evidences":[{"source":"PubMed","id":"10338009","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	1
Details	Modified residue: {"description":"N-formylmethionine","evidences":[{"source":"PubMed","id":"220175","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P00406","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI25
Number of Residues	384
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"27605664","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI26
Number of Residues	4
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P19783","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI27
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P13073","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI28
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P10888","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI29
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P19783","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI30
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P12787","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI31
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P20674","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI32
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20385840","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27605664","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8638158","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI33
Number of Residues	6
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P19536","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI34
Number of Residues	92
Details	Domain: {"description":"CHCH","evidences":[{"source":"PROSITE-ProRule","id":"PRU01150","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI35
Number of Residues	20
Details	Motif: {"description":"Cx9C motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01150","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI36
Number of Residues	22
Details	Motif: {"description":"Cx10C motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01150","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI37
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P56391","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI38
Number of Residues	2
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P17665","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	14
Details	M-CSA 124

Chain	Residue	Details
A	HIS61	metal ligand
A	HIS290	metal ligand
A	HIS291	metal ligand, proton acceptor, proton donor
A	THR316	proton acceptor, proton donor, proton relay
A	LYS319	proton acceptor, proton donor, proton relay
A	ARG438	proton acceptor, proton donor, proton relay
A	ASP91	proton acceptor, proton donor, proton relay
A	TRP126	proton acceptor, proton donor, proton relay
A	SER156	proton acceptor, proton donor, proton relay
A	SER157	proton acceptor, proton donor, proton relay
A	HIS240	covalently attached, electrostatic stabiliser, metal ligand, radical stabiliser
A	GLU242	proton acceptor, proton donor, proton relay
A	TYR244	covalently attached, hydrogen radical donor, proton acceptor, proton donor, proton relay, single electron acceptor
A	SER255	proton acceptor, proton donor, proton relay

---

site_id	MCSA2
Number of Residues	14
Details	M-CSA 124

Chain	Residue	Details
N	HIS61	metal ligand
N	HIS290	metal ligand
N	HIS291	metal ligand, proton acceptor, proton donor
N	THR316	proton acceptor, proton donor, proton relay
N	LYS319	proton acceptor, proton donor, proton relay
N	ARG438	proton acceptor, proton donor, proton relay
N	ASP91	proton acceptor, proton donor, proton relay
N	TRP126	proton acceptor, proton donor, proton relay
N	SER156	proton acceptor, proton donor, proton relay
N	SER157	proton acceptor, proton donor, proton relay
N	HIS240	covalently attached, electrostatic stabiliser, metal ligand, radical stabiliser
N	GLU242	proton acceptor, proton donor, proton relay
N	TYR244	covalently attached, hydrogen radical donor, proton acceptor, proton donor, proton relay, single electron acceptor
N	SER255	proton acceptor, proton donor, proton relay

---