2Y5Z
Mixed-function P450 MycG in complex with mycinamicin III in C2221 space group
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004497 | molecular_function | monooxygenase activity |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| A | 0017000 | biological_process | antibiotic biosynthetic process |
| A | 0020037 | molecular_function | heme binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0055114 | biological_process | obsolete oxidation-reduction process |
| B | 0004497 | molecular_function | monooxygenase activity |
| B | 0005506 | molecular_function | iron ion binding |
| B | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| B | 0017000 | biological_process | antibiotic biosynthetic process |
| B | 0020037 | molecular_function | heme binding |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0055114 | biological_process | obsolete oxidation-reduction process |
| C | 0004497 | molecular_function | monooxygenase activity |
| C | 0005506 | molecular_function | iron ion binding |
| C | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
| C | 0017000 | biological_process | antibiotic biosynthetic process |
| C | 0020037 | molecular_function | heme binding |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0055114 | biological_process | obsolete oxidation-reduction process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE HEM A 450 |
| Chain | Residue |
| A | LEU83 |
| A | THR239 |
| A | PHE286 |
| A | ARG288 |
| A | GLY338 |
| A | PHE339 |
| A | GLY340 |
| A | HIS344 |
| A | CYS346 |
| A | GLY348 |
| A | LEU356 |
| A | LEU84 |
| A | HOH2162 |
| A | HOH2257 |
| A | HOH2258 |
| A | HIS91 |
| A | ARG95 |
| A | PHE102 |
| A | LEU231 |
| A | ALA234 |
| A | GLY235 |
| A | SER238 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE ZM3 A 460 |
| Chain | Residue |
| A | ARG75 |
| A | GLU77 |
| A | VAL79 |
| A | PHE168 |
| A | SER170 |
| A | VAL174 |
| A | MET179 |
| A | LEU386 |
| A | HOH2260 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE BEN A 1398 |
| Chain | Residue |
| A | HIS119 |
| A | ARG366 |
| A | HOH2261 |
| A | HOH2262 |
| B | HIS119 |
| B | ARG366 |
| B | BEN1398 |
| B | HOH2264 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 1399 |
| Chain | Residue |
| A | ARG140 |
| A | THR240 |
| A | THR241 |
| A | GLY389 |
| A | PRO390 |
| A | HOH2263 |
| site_id | AC5 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL A 1400 |
| Chain | Residue |
| A | LEU56 |
| A | GLY57 |
| A | GLY59 |
| A | PRO88 |
| A | GLY342 |
| A | VAL343 |
| A | HOH2093 |
| A | HOH2264 |
| C | ASP325 |
| C | HOH2207 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 1401 |
| Chain | Residue |
| A | ARG73 |
| A | THR74 |
| A | VAL282 |
| A | GLY283 |
| A | THR284 |
| A | LEU386 |
| A | HOH2082 |
| site_id | AC7 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A 1402 |
| Chain | Residue |
| A | GLN318 |
| A | ALA319 |
| A | PHE321 |
| A | PRO322 |
| A | HOH2265 |
| C | PRO89 |
| C | SER92 |
| C | ARG93 |
| C | ARG96 |
| site_id | AC8 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE HEM B 450 |
| Chain | Residue |
| B | LEU83 |
| B | LEU84 |
| B | HIS91 |
| B | ARG95 |
| B | PHE102 |
| B | ALA234 |
| B | GLY235 |
| B | SER238 |
| B | THR239 |
| B | PHE286 |
| B | ARG288 |
| B | GLY338 |
| B | PHE339 |
| B | GLY340 |
| B | HIS344 |
| B | CYS346 |
| B | GLY348 |
| B | HOH2153 |
| B | HOH2192 |
| B | HOH2262 |
| B | HOH2263 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ZM3 B 460 |
| Chain | Residue |
| B | ARG75 |
| B | GLU77 |
| B | VAL79 |
| B | VAL174 |
| B | ALA176 |
| B | MET179 |
| B | LEU386 |
| site_id | BC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE BEN B 1398 |
| Chain | Residue |
| A | HIS119 |
| A | ARG366 |
| A | BEN1398 |
| A | HOH2261 |
| A | HOH2262 |
| B | HIS119 |
| B | ARG366 |
| B | HOH2264 |
| site_id | BC2 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE GOL B 1399 |
| Chain | Residue |
| B | LEU56 |
| B | GLY57 |
| B | GLY59 |
| B | PHE61 |
| B | PRO88 |
| B | ASP325 |
| B | GLY342 |
| B | VAL343 |
| B | HOH2088 |
| B | HOH2209 |
| B | HOH2265 |
| site_id | BC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL B 1400 |
| Chain | Residue |
| B | ARG140 |
| B | THR240 |
| B | THR241 |
| B | ALA244 |
| B | GLY389 |
| B | PRO390 |
| B | LEU391 |
| B | HOH2139 |
| B | HOH2154 |
| site_id | BC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 1401 |
| Chain | Residue |
| B | GLN27 |
| B | ARG48 |
| B | ARG96 |
| B | ASP317 |
| B | HOH2030 |
| B | HOH2266 |
| site_id | BC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL B 1402 |
| Chain | Residue |
| B | PRO65 |
| B | ALA290 |
| B | VAL291 |
| site_id | BC6 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE HEM C 450 |
| Chain | Residue |
| C | LEU83 |
| C | LEU84 |
| C | HIS91 |
| C | ARG95 |
| C | PHE102 |
| C | LEU231 |
| C | ALA234 |
| C | GLY235 |
| C | SER238 |
| C | THR239 |
| C | PHE286 |
| C | ARG288 |
| C | GLY338 |
| C | PHE339 |
| C | GLY340 |
| C | HIS344 |
| C | CYS346 |
| C | GLY348 |
| C | ALA352 |
| C | HOH2149 |
| C | HOH2256 |
| site_id | BC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ZM3 C 460 |
| Chain | Residue |
| C | GLU77 |
| C | VAL79 |
| C | SER170 |
| C | VAL174 |
| C | ALA176 |
| C | MET179 |
| C | LEU386 |
| site_id | BC8 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE BEN C 1398 |
| Chain | Residue |
| C | HIS119 |
| C | HIS119 |
| C | ARG366 |
| C | ARG366 |
| C | HOH2257 |
| C | HOH2257 |
| C | HOH2258 |
| C | HOH2258 |
| site_id | BC9 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE GOL C 1399 |
| Chain | Residue |
| A | ASP325 |
| C | LEU56 |
| C | GLY57 |
| C | GLY59 |
| C | PHE61 |
| C | PRO88 |
| C | GLY342 |
| C | VAL343 |
| C | HOH2079 |
| C | HOH2259 |
| C | HOH2260 |
| site_id | CC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL C 1400 |
| Chain | Residue |
| C | ARG140 |
| C | THR240 |
| C | THR241 |
| C | GLY389 |
| C | PRO390 |
| C | LEU391 |
| C | HOH2130 |
Functional Information from PROSITE/UniProt
| site_id | PS00086 |
| Number of Residues | 10 |
| Details | CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGhGVHHCLG |
| Chain | Residue | Details |
| A | PHE339-GLY348 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22952225, ECO:0007744|PDB:2Y46, ECO:0007744|PDB:2Y98, ECO:0007744|PDB:3ZSN |
| Chain | Residue | Details |
| A | GLY81 | |
| B | GLY81 | |
| C | GLY81 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22952225 |
| Chain | Residue | Details |
| A | HIS91 | |
| C | ARG95 | |
| C | ARG288 | |
| C | HIS344 | |
| A | ARG95 | |
| A | ARG288 | |
| A | HIS344 | |
| B | HIS91 | |
| B | ARG95 | |
| B | ARG288 | |
| B | HIS344 | |
| C | HIS91 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | BINDING: axial binding residue => ECO:0000269|PubMed:22952225, ECO:0007744|PDB:2Y5N, ECO:0007744|PDB:2Y98, ECO:0007744|PDB:2YCA |
| Chain | Residue | Details |
| A | CYS346 | |
| B | CYS346 | |
| C | CYS346 |
