2Y5S
Crystal structure of Burkholderia cenocepacia dihydropteroate synthase complexed with 7,8-dihydropteroate.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004156 | molecular_function | dihydropteroate synthase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0009396 | biological_process | folic acid-containing compound biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0042558 | biological_process | pteridine-containing compound metabolic process |
| A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| A | 0046656 | biological_process | folic acid biosynthetic process |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004156 | molecular_function | dihydropteroate synthase activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0009396 | biological_process | folic acid-containing compound biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0042558 | biological_process | pteridine-containing compound metabolic process |
| B | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| B | 0046656 | biological_process | folic acid biosynthetic process |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE 78H A 1293 |
| Chain | Residue |
| A | THR68 |
| A | SER234 |
| A | ARG268 |
| A | EDO1304 |
| A | HOH2099 |
| A | HOH2100 |
| A | HOH2152 |
| A | ARG69 |
| A | ASP101 |
| A | ASN120 |
| A | MET144 |
| A | ASP191 |
| A | PHE196 |
| A | GLY229 |
| A | LYS233 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL A 1294 |
| Chain | Residue |
| A | VAL201 |
| A | ASP202 |
| A | HOH2055 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 1295 |
| Chain | Residue |
| A | ALA199 |
| A | ASP203 |
| A | EDO1301 |
| A | HOH2104 |
| A | HOH2154 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO A 1296 |
| Chain | Residue |
| A | ALA254 |
| A | CYS258 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 1297 |
| Chain | Residue |
| A | ARG126 |
| A | MET146 |
| A | LEU147 |
| A | GLY148 |
| A | PHE170 |
| A | HOH2153 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 1298 |
| Chain | Residue |
| A | ARG109 |
| A | ASP132 |
| A | LYS198 |
| A | ALA199 |
| A | VAL200 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO A 1299 |
| Chain | Residue |
| A | ALA173 |
| A | ARG174 |
| site_id | AC8 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE EDO A 1300 |
| Chain | Residue |
| B | VAL249 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 1301 |
| Chain | Residue |
| A | ASP162 |
| A | VAL163 |
| A | ASP202 |
| A | ASP203 |
| A | EDO1295 |
| A | HOH2154 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 1302 |
| Chain | Residue |
| A | PHE4 |
| A | LEU5 |
| A | ALA7 |
| A | ARG222 |
| A | ALA223 |
| A | HOH2115 |
| site_id | BC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 1303 |
| Chain | Residue |
| A | GLU51 |
| A | ILE54 |
| A | ALA55 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 1304 |
| Chain | Residue |
| A | ILE26 |
| A | ARG268 |
| A | HIS270 |
| A | 78H1293 |
| A | HOH2156 |
| site_id | BC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 1305 |
| Chain | Residue |
| A | ARG69 |
| A | ILE122 |
| A | TRP123 |
| A | MET153 |
| A | VAL155 |
| site_id | BC5 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE 78H B 1293 |
| Chain | Residue |
| B | THR68 |
| B | ARG69 |
| B | ASP101 |
| B | ASN120 |
| B | MET144 |
| B | ASP191 |
| B | PHE196 |
| B | GLY229 |
| B | LYS233 |
| B | SER234 |
| B | ARG268 |
| B | EDO1297 |
| B | HOH2090 |
| B | HOH2146 |
| B | HOH2148 |
| site_id | BC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL B 1294 |
| Chain | Residue |
| B | ARG109 |
| B | VAL201 |
| B | ASP202 |
| B | HOH2041 |
| site_id | BC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO B 1295 |
| Chain | Residue |
| B | ARG109 |
| B | ASP132 |
| B | LYS198 |
| B | ALA199 |
| B | VAL200 |
| B | HOH2147 |
| site_id | BC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 1296 |
| Chain | Residue |
| B | ARG69 |
| B | ARG232 |
| B | HIS270 |
| B | EDO1297 |
| B | HOH2148 |
| site_id | BC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 1297 |
| Chain | Residue |
| B | SER234 |
| B | ARG248 |
| B | 78H1293 |
| B | EDO1296 |
| site_id | CC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 1298 |
| Chain | Residue |
| B | ALA173 |
| B | ARG174 |
| B | HOH2051 |
| B | HOH2149 |
| B | ARG126 |
| site_id | CC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 1299 |
| Chain | Residue |
| B | ARG126 |
| B | MET146 |
| B | LEU147 |
| B | GLY148 |
| B | HOH2066 |
Functional Information from PROSITE/UniProt
