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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2Y5B

Structure of USP21 in complex with linear diubiquitin-aldehyde

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004843	molecular_function	cysteine-type deubiquitinase activity
A	0016579	biological_process	protein deubiquitination
E	0004843	molecular_function	cysteine-type deubiquitinase activity
E	0016579	biological_process	protein deubiquitination

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1000

Chain	Residue
A	CYS384
A	CYS387
A	CYS437
A	CYS440

site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 1559

Chain	Residue
A	SER472
A	ILE473

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 1560

Chain	Residue
A	VAL514
F	ARG54
A	LYS474
A	LYS475
A	SER513

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 E 1560

Chain	Residue
E	PRO235
E	LYS369
E	ARG457

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 E 1561

Chain	Residue
E	GLU276
E	ALA277

site_id	AC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 A 1561

Chain	Residue
A	ARG320

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 1562

Chain	Residue
A	PRO235
A	LYS369
A	ARG457

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 1563

Chain	Residue
A	PRO483
A	LEU484
A	GLN485

site_id	AC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 E 1562

Chain	Residue
E	ARG320

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 1564

Chain	Residue
A	SER541
A	ASN543
E	GLY296

site_id	BC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 1152

Chain	Residue
A	HIS515
B	GLN116
B	ARG150

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 F 1152

Chain	Residue
F	GLN116
F	ARG148
F	ARG150

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 1565

Chain	Residue
A	ARG215
A	ASN216
A	ARG390
A	ASP534
A	SER535

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN E 1000

Chain	Residue
E	CYS384
E	CYS387
E	CYS437
E	CYS440

Functional Information from PROSITE/UniProt

site_id	PS00299
Number of Residues	26
Details	UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD

Chain	Residue	Details
B	LYS27-ASP52
B	LYS103-ASP128

site_id	PS00972
Number of Residues	16
Details	USP_1 Ubiquitin specific protease (USP) domain signature 1. GLrnlGNtCFLNAvLQ

Chain	Residue	Details
A	GLY213-GLN228

site_id	PS00973
Number of Residues	18
Details	USP_2 Ubiquitin specific protease (USP) domain signature 2. YqLyALcnHsGsvhy..GHY

Chain	Residue	Details
A	TYR502-TYR519

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	SITE: Interacts with activating enzyme

Chain	Residue	Details
B	ARG54
B	ARG72
F	ARG54
F	ARG72

site_id	SWS_FT_FI2
Number of Residues	2
Details	SITE: Essential for function

Chain	Residue	Details
B	HIS68
F	HIS68

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphoserine; by PINK1 => ECO:0000269\|PubMed:24660806, ECO:0000269\|PubMed:24751536, ECO:0000269\|PubMed:24784582, ECO:0000269\|PubMed:25527291

Chain	Residue	Details
B	SER65
F	SER65
A	CYS437
A	CYS440
E	CYS384
E	CYS387
E	CYS437
E	CYS440

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: (Microbial infection) ADP-ribosylthreonine => ECO:0000269\|PubMed:32330457

Chain	Residue	Details
B	THR66
F	THR66

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: ADP-ribosylglycine => ECO:0000269\|PubMed:28525742

Chain	Residue	Details
B	HIS76
F	HIS76

site_id	SWS_FT_FI6
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269\|PubMed:16443603

Chain	Residue	Details
B	LYS6
F	LYS6

site_id	SWS_FT_FI7
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)

Chain	Residue	Details
B	HIS76
F	HIS76

site_id	SWS_FT_FI8
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269\|PubMed:16443603, ECO:0000269\|PubMed:16543144

Chain	Residue	Details
B	LYS11
B	LYS48
F	LYS11
F	LYS48

site_id	SWS_FT_FI9
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305\|PubMed:15466860

Chain	Residue	Details
B	LYS27
F	LYS27

site_id	SWS_FT_FI10
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269\|PubMed:16543144, ECO:0000269\|PubMed:25752573, ECO:0000269\|PubMed:25752577, ECO:0000269\|PubMed:34239127

Chain	Residue	Details
B	LYS29
F	LYS29

site_id	SWS_FT_FI11
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269\|PubMed:25752577

Chain	Residue	Details
B	LYS33
F	LYS33

site_id	SWS_FT_FI12
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269\|PubMed:16543144, ECO:0000269\|PubMed:18719106

Chain	Residue	Details
B	LYS63
F	LYS63

218853

PDB entries from 2024-04-24

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