Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2Y56

Fragment growing induces conformational changes in acetylcholine- binding protein: A structural and thermodynamic analysis - (Compound 3)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0005231	molecular_function	excitatory extracellular ligand-gated monoatomic ion channel activity
A	0005515	molecular_function	protein binding
A	0006811	biological_process	monoatomic ion transport
A	0007165	biological_process	signal transduction
A	0007268	biological_process	chemical synaptic transmission
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0042391	biological_process	regulation of membrane potential
A	0042802	molecular_function	identical protein binding
A	0043005	cellular_component	neuron projection
A	0045202	cellular_component	synapse
A	0046872	molecular_function	metal ion binding
A	0050877	biological_process	nervous system process
A	0060078	biological_process	regulation of postsynaptic membrane potential
A	0060079	biological_process	excitatory postsynaptic potential
A	0098794	cellular_component	postsynapse
A	1904315	molecular_function	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0005231	molecular_function	excitatory extracellular ligand-gated monoatomic ion channel activity
B	0005515	molecular_function	protein binding
B	0006811	biological_process	monoatomic ion transport
B	0007165	biological_process	signal transduction
B	0007268	biological_process	chemical synaptic transmission
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0042391	biological_process	regulation of membrane potential
B	0042802	molecular_function	identical protein binding
B	0043005	cellular_component	neuron projection
B	0045202	cellular_component	synapse
B	0046872	molecular_function	metal ion binding
B	0050877	biological_process	nervous system process
B	0060078	biological_process	regulation of postsynaptic membrane potential
B	0060079	biological_process	excitatory postsynaptic potential
B	0098794	cellular_component	postsynapse
B	1904315	molecular_function	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0005231	molecular_function	excitatory extracellular ligand-gated monoatomic ion channel activity
C	0005515	molecular_function	protein binding
C	0006811	biological_process	monoatomic ion transport
C	0007165	biological_process	signal transduction
C	0007268	biological_process	chemical synaptic transmission
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0042391	biological_process	regulation of membrane potential
C	0042802	molecular_function	identical protein binding
C	0043005	cellular_component	neuron projection
C	0045202	cellular_component	synapse
C	0046872	molecular_function	metal ion binding
C	0050877	biological_process	nervous system process
C	0060078	biological_process	regulation of postsynaptic membrane potential
C	0060079	biological_process	excitatory postsynaptic potential
C	0098794	cellular_component	postsynapse
C	1904315	molecular_function	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0005231	molecular_function	excitatory extracellular ligand-gated monoatomic ion channel activity
D	0005515	molecular_function	protein binding
D	0006811	biological_process	monoatomic ion transport
D	0007165	biological_process	signal transduction
D	0007268	biological_process	chemical synaptic transmission
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0042391	biological_process	regulation of membrane potential
D	0042802	molecular_function	identical protein binding
D	0043005	cellular_component	neuron projection
D	0045202	cellular_component	synapse
D	0046872	molecular_function	metal ion binding
D	0050877	biological_process	nervous system process
D	0060078	biological_process	regulation of postsynaptic membrane potential
D	0060079	biological_process	excitatory postsynaptic potential
D	0098794	cellular_component	postsynapse
D	1904315	molecular_function	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0005231	molecular_function	excitatory extracellular ligand-gated monoatomic ion channel activity
E	0005515	molecular_function	protein binding
E	0006811	biological_process	monoatomic ion transport
E	0007165	biological_process	signal transduction
E	0007268	biological_process	chemical synaptic transmission
E	0016020	cellular_component	membrane
E	0034220	biological_process	monoatomic ion transmembrane transport
E	0042391	biological_process	regulation of membrane potential
E	0042802	molecular_function	identical protein binding
E	0043005	cellular_component	neuron projection
E	0045202	cellular_component	synapse
E	0046872	molecular_function	metal ion binding
E	0050877	biological_process	nervous system process
E	0060078	biological_process	regulation of postsynaptic membrane potential
E	0060079	biological_process	excitatory postsynaptic potential
E	0098794	cellular_component	postsynapse
E	1904315	molecular_function	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE V11 A 301

Chain	Residue
A	THR89
A	TYR193
A	CL502
B	TYR53
B	GLN55
B	ILE116
A	TYR91
A	LYS141
A	GLY143
A	SER144
A	TRP145
A	TYR186
A	CYS188
A	CYS189

site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 501

Chain	Residue
A	LYS40
E	ARG95

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 502

Chain	Residue
A	V11301
B	ILE116

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 601

Chain	Residue
A	LYS141
A	GLN182
A	GLN184

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 602

Chain	Residue
A	GLN1
A	ALA2
A	ASN3

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL A 701

Chain	Residue
A	THR158
A	ASP159

site_id	AC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE GOL A 702

Chain	Residue
A	ARG205

site_id	AC8
Number of Residues	11
Details	BINDING SITE FOR RESIDUE V11 B 301

Chain	Residue
B	THR89
B	TYR91
B	GLY143
B	SER144
B	TRP145
B	TYR186
B	CYS188
B	CYS189
B	TYR193
C	GLN55
C	ILE116

site_id	AC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL B 501

Chain	Residue
B	LYS40

site_id	BC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL B 502

Chain	Residue
C	ILE116

site_id	BC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL B 503

Chain	Residue
B	TYR147

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 601

Chain	Residue
A	ASP126
B	TYR167
B	SER169

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 602

Chain	Residue
B	GLN1
B	ALA2
B	ASN3

site_id	BC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL B 701

Chain	Residue
B	TYR186
B	SER187
B	CYS188
C	ASP162
C	SER164
C	SER165

site_id	BC6
Number of Residues	12
Details	BINDING SITE FOR RESIDUE V11 C 301

Chain	Residue
C	THR89
C	TYR91
C	LYS141
C	GLY143
C	SER144
C	TRP145
C	TYR186
C	CYS188
C	CYS189
C	TYR193
C	CL502
D	ILE116

site_id	BC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL C 501

Chain	Residue
B	ARG95
C	LYS40

site_id	BC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL C 502

Chain	Residue
C	V11301
D	ILE116

site_id	BC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 C 601

Chain	Residue
C	GLN1
C	ALA2
C	ASN3

site_id	CC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 602

Chain	Residue
C	ASP25
C	LYS59
C	LEU60
C	ASN61

site_id	CC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL C 701

Chain	Residue
C	TYR186
C	SER187
C	CYS188
D	TYR53
D	ASP162
D	SER164
D	SER165

site_id	CC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL C 702

Chain	Residue
C	SER93
C	ARG95
C	PRO96
C	VAL97
D	LEU100

site_id	CC4
Number of Residues	12
Details	BINDING SITE FOR RESIDUE V11 D 301

Chain	Residue
E	ILE116
D	THR89
D	TYR91
D	GLY143
D	SER144
D	TRP145
D	TYR186
D	CYS188
D	CYS189
D	TYR193
D	CL503
E	GLN55

site_id	CC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL D 501

Chain	Residue
C	ARG95
D	LYS40

site_id	CC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL D 502

Chain	Residue
D	SER165

site_id	CC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL D 503

Chain	Residue
D	V11301
E	ILE116

site_id	CC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 D 601

Chain	Residue
B	HIS185
C	ASP126
D	TYR167
D	SER169

site_id	CC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 D 602

Chain	Residue
D	LYS141
D	GLN182
D	ASN197

site_id	DC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 D 603

Chain	Residue
D	GLN1
D	ALA2
D	ASN3

site_id	DC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL D 701

Chain	Residue
D	ASP157
D	THR158
D	ASP159

site_id	DC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL D 702

Chain	Residue
D	MET17
D	ILE83
D	TRP84
D	THR85

site_id	DC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL D 703

Chain	Residue
D	SER79
D	PRO102
D	GLN103

site_id	DC5
Number of Residues	11
Details	BINDING SITE FOR RESIDUE V11 E 301

Chain	Residue
A	ILE116
E	THR89
E	TYR91
E	LYS141
E	GLY143
E	SER144
E	TRP145
E	TYR186
E	CYS188
E	TYR193
E	CL502

site_id	DC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL E 501

Chain	Residue
E	LYS40

site_id	DC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL E 502

Chain	Residue
A	ILE116
E	V11301

site_id	DC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 E 601

Chain	Residue
E	LYS141
E	GLN182
E	ASN197

site_id	DC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 E 602

Chain	Residue
D	ASP126
E	TYR167
E	SER169

site_id	EC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 E 603

Chain	Residue
E	GLN1
E	ALA2
E	ASN3

site_id	EC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 E 604

Chain	Residue
D	TYR91
D	SER92
E	GLN36
E	SER165
E	TYR167

site_id	EC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 E 605

Chain	Residue
A	TYR167
A	SER169
E	ASP126

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)