2Y4R
CRYSTAL STRUCTURE OF 4-AMINO-4-DEOXYCHORISMATE LYASE FROM PSEUDOMONAS AERUGINOSA
Replaces: 2Y1UReplaces: 2XPFFunctional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0008153 | biological_process | 4-aminobenzoate biosynthetic process |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0008696 | molecular_function | 4-amino-4-deoxychorismate lyase activity |
| A | 0009396 | biological_process | folic acid-containing compound biosynthetic process |
| A | 0016829 | molecular_function | lyase activity |
| A | 0030170 | molecular_function | pyridoxal phosphate binding |
| A | 0046394 | biological_process | carboxylic acid biosynthetic process |
| A | 0046656 | biological_process | folic acid biosynthetic process |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0008153 | biological_process | 4-aminobenzoate biosynthetic process |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0008696 | molecular_function | 4-amino-4-deoxychorismate lyase activity |
| B | 0009396 | biological_process | folic acid-containing compound biosynthetic process |
| B | 0016829 | molecular_function | lyase activity |
| B | 0030170 | molecular_function | pyridoxal phosphate binding |
| B | 0046394 | biological_process | carboxylic acid biosynthetic process |
| B | 0046656 | biological_process | folic acid biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE PLP A 1140 |
| Chain | Residue |
| A | ARG46 |
| A | MET201 |
| A | ASN236 |
| A | SER237 |
| A | HOH2231 |
| B | TYR92 |
| A | LYS140 |
| A | GLU173 |
| A | VAL175 |
| A | SER177 |
| A | ASN178 |
| A | VAL197 |
| A | GLY199 |
| A | VAL200 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PG4 A 1272 |
| Chain | Residue |
| A | GLU49 |
| A | ARG53 |
| A | HOH2232 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PG4 A 1273 |
| Chain | Residue |
| A | ARG127 |
| A | THR128 |
| A | LEU149 |
| A | GLU153 |
| A | HOH2112 |
| A | HOH2233 |
| B | LEU135 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PG4 A 1274 |
| Chain | Residue |
| A | ALA34 |
| A | GLY75 |
| A | GLU207 |
| A | GLU210 |
| A | LEU216 |
| A | ILE218 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL A 1275 |
| Chain | Residue |
| A | ARG102 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL A 1276 |
| Chain | Residue |
| A | ARG122 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1277 |
| Chain | Residue |
| A | LEU192 |
| A | ARG202 |
| A | ILE218 |
| A | PEG1280 |
| A | HOH2234 |
| A | HOH2235 |
| A | HOH2236 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 1278 |
| Chain | Residue |
| A | ARG194 |
| A | ARG208 |
| A | ASP268 |
| A | HOH2120 |
| A | HOH2237 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 1279 |
| Chain | Residue |
| A | PRO215 |
| A | HOH2238 |
| B | ALA224 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PEG A 1280 |
| Chain | Residue |
| A | ALA203 |
| A | GLU207 |
| A | ILE218 |
| A | SO41277 |
| A | HOH2014 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 1281 |
| Chain | Residue |
| A | ARG90 |
| A | GLY91 |
| A | TYR92 |
| A | ALA93 |
| B | ARG151 |
| B | PHE176 |
| site_id | BC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A 1282 |
| Chain | Residue |
| A | HIS168 |
| B | HIS168 |
| site_id | BC4 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE PLP B 1140 |
| Chain | Residue |
| A | TYR92 |
| B | ARG46 |
| B | LYS140 |
| B | GLN147 |
| B | GLU173 |
| B | VAL175 |
| B | SER177 |
| B | ASN178 |
| B | VAL197 |
| B | GLY199 |
| B | VAL200 |
| B | MET201 |
| B | ASN236 |
| B | SER237 |
| B | HOH2225 |
| site_id | BC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PG4 B 1272 |
| Chain | Residue |
| B | GLU49 |
| B | ARG53 |
| B | GLY138 |
| B | ASP156 |
| B | ALA198 |
| B | PEG1277 |
| B | HOH2226 |
| B | HOH2232 |
| B | HOH2233 |
| site_id | BC6 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE PG4 B 1273 |
| Chain | Residue |
| A | ARG53 |
| A | LEU54 |
| A | ALA55 |
| A | PRO94 |
| A | LEU135 |
| B | THR128 |
| B | LEU149 |
| B | ALA152 |
| B | GLU153 |
| B | HOH2227 |
| B | HOH2229 |
| B | HOH2230 |
| site_id | BC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PEG B 1274 |
| Chain | Residue |
| B | GLY120 |
| B | ARG245 |
| B | HOH2231 |
| site_id | BC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1275 |
| Chain | Residue |
| B | LEU192 |
| B | ARG202 |
| B | ILE218 |
| B | HOH2232 |
| B | HOH2233 |
| site_id | BC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 1276 |
| Chain | Residue |
| B | GLU48 |
| B | CYS51 |
| B | ILE56 |
| B | LEU58 |
| site_id | CC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PEG B 1277 |
| Chain | Residue |
| B | HIS159 |
| B | PG41272 |
| B | HOH2234 |
| site_id | CC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 1278 |
| Chain | Residue |
| A | ARG151 |
| A | PHE176 |
| B | ARG90 |
| B | GLY91 |
| B | TYR92 |
| B | ALA93 |
| B | HOH2235 |
