2Y31
Simocyclinone C4 bound form of TetR-like repressor SimR
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000976 | molecular_function | transcription cis-regulatory region binding |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0006351 | biological_process | DNA-templated transcription |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000976 | molecular_function | transcription cis-regulatory region binding |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003700 | molecular_function | DNA-binding transcription factor activity |
| B | 0006351 | biological_process | DNA-templated transcription |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE SMQ A 501 |
| Chain | Residue |
| A | MET185 |
| B | PRO126 |
| B | GLN135 |
| B | GLN136 |
| B | LEU154 |
| B | ASN161 |
| B | HOH2057 |
| A | MET189 |
| A | GLY193 |
| A | GLN197 |
| A | LEU212 |
| A | HIS219 |
| A | HOH2140 |
| A | HOH2166 |
| A | HOH2168 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE SMQ B 501 |
| Chain | Residue |
| A | LYS107 |
| A | PRO126 |
| A | GLN135 |
| A | GLN136 |
| A | LEU154 |
| A | ASN161 |
| A | HOH2097 |
| B | MET189 |
| B | GLY193 |
| B | GLN197 |
| B | LEU212 |
| B | PRO218 |
| B | HIS219 |
| B | HOH2099 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE 1PE A 1248 |
| Chain | Residue |
| A | ARG232 |
| A | ASP235 |
| A | SER236 |
| A | HOH2159 |
| A | HOH2169 |
| B | SER240 |
| B | ARG243 |
| B | LEU244 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PG4 A 1249 |
| Chain | Residue |
| A | LEU88 |
| A | PRO89 |
| A | ASP90 |
| A | ARG134 |
| A | GLU137 |
| A | PHE138 |
| A | HOH2045 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 1247 |
| Chain | Residue |
| A | LEU244 |
| A | HOH2088 |
| A | HOH2090 |
| B | ASP235 |
| B | HOH2040 |
| B | HOH2041 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CL B 1248 |
| Chain | Residue |
| A | HOH2073 |
| B | GLY44 |
| B | VAL45 |
| B | TRP116 |
| B | HOH2018 |
| B | HOH2053 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL B 1249 |
| Chain | Residue |
| B | LYS71 |
| B | HOH2024 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL B 1250 |
| Chain | Residue |
| B | MET185 |
| B | HOH2092 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL A 1250 |
| Chain | Residue |
| A | TRP174 |
| A | ASP184 |
| A | MET185 |
| A | HOH2106 |
| A | HOH2120 |
| site_id | BC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL B 1251 |
| Chain | Residue |
| B | MET50 |
| B | HOH2020 |
| B | HOH2024 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 1251 |
| Chain | Residue |
| A | GLY44 |
| A | VAL45 |
| A | HOH2018 |
| B | HOH2056 |
| site_id | BC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL B 1252 |
| Chain | Residue |
| B | GLY221 |
| B | ASP223 |
| B | GLN224 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 1252 |
| Chain | Residue |
| A | GLY221 |
| A | ASP223 |
| A | GLN224 |
| A | HOH2145 |
