2Y30
Simocyclinone D8 bound form of TetR-like repressor SimR
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000976 | molecular_function | transcription cis-regulatory region binding |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0006351 | biological_process | DNA-templated transcription |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000976 | molecular_function | transcription cis-regulatory region binding |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003700 | molecular_function | DNA-binding transcription factor activity |
| B | 0006351 | biological_process | DNA-templated transcription |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE SM8 A 501 |
| Chain | Residue |
| A | MET189 |
| B | ALA103 |
| B | LYS107 |
| B | PRO126 |
| B | GLN136 |
| B | VAL139 |
| B | LEU154 |
| B | TYR160 |
| B | ASN161 |
| B | HOH2037 |
| A | GLY193 |
| A | GLN197 |
| A | LEU212 |
| A | THR215 |
| A | PRO218 |
| A | HIS219 |
| B | ILE83 |
| B | THR86 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A 1247 |
| Chain | Residue |
| A | VAL45 |
| A | TRP116 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A 1248 |
| Chain | Residue |
| A | MET50 |
| A | LYS71 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A 1249 |
| Chain | Residue |
| A | ASP184 |
| A | MET185 |
| site_id | AC5 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE SM8 B 501 |
| Chain | Residue |
| A | GLU43 |
| A | ALA47 |
| A | ILE83 |
| A | THR86 |
| A | ALA103 |
| A | LYS107 |
| A | GLN135 |
| A | GLN136 |
| A | VAL139 |
| A | LEU154 |
| A | ILE157 |
| A | TYR160 |
| A | ASN161 |
| B | MET189 |
| B | SER192 |
| B | GLY193 |
| B | GLN197 |
| B | VAL200 |
| B | LEU212 |
| B | HIS219 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL B 1248 |
| Chain | Residue |
| B | GLY44 |
| B | VAL45 |
| B | TRP116 |
| site_id | AC7 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL B 1249 |
| Chain | Residue |
| B | LYS71 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL B 1250 |
| Chain | Residue |
| B | TRP174 |
| B | MET185 |
