2Y0P
Crystal structure of the SucA domain of Mycobacterium smegmatis alpha- ketoglutarate decarboxylase in complex with the enamine-ThDP intermediate and acetyl-CoA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016624 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor |
| A | 0030976 | molecular_function | thiamine pyrophosphate binding |
| B | 0016624 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor |
| B | 0030976 | molecular_function | thiamine pyrophosphate binding |
| C | 0016624 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor |
| C | 0030976 | molecular_function | thiamine pyrophosphate binding |
| D | 0016624 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor |
| D | 0030976 | molecular_function | thiamine pyrophosphate binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE TD7 A 2001 |
| Chain | Residue |
| A | PHE506 |
| A | ASP645 |
| A | ALA646 |
| A | ALA647 |
| A | ASN678 |
| A | ILE680 |
| A | GLY681 |
| A | HIS747 |
| A | MG2002 |
| A | HOH2036 |
| A | HOH2041 |
| A | HIS539 |
| B | GLN901 |
| B | LEU950 |
| B | GLU952 |
| B | GLN976 |
| B | PHE980 |
| B | HIS1020 |
| A | ARG540 |
| A | TYR578 |
| A | HIS579 |
| A | SER604 |
| A | HIS605 |
| A | LEU606 |
| A | GLY644 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 2002 |
| Chain | Residue |
| A | ASP645 |
| A | ASN678 |
| A | ILE680 |
| A | TD72001 |
| A | HOH2036 |
| site_id | AC3 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE TD7 B 2001 |
| Chain | Residue |
| A | GLN901 |
| A | LEU950 |
| A | GLU952 |
| A | GLN976 |
| A | PHE980 |
| A | HIS1020 |
| B | HIS539 |
| B | ARG540 |
| B | TYR578 |
| B | HIS579 |
| B | SER604 |
| B | HIS605 |
| B | LEU606 |
| B | GLY644 |
| B | ASP645 |
| B | ALA646 |
| B | ALA647 |
| B | ASN678 |
| B | ILE680 |
| B | GLY681 |
| B | HIS747 |
| B | MG2002 |
| B | HOH2044 |
| B | HOH2050 |
| B | HOH2140 |
| B | HOH2141 |
| B | HOH2142 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG B 2002 |
| Chain | Residue |
| B | ASP645 |
| B | ASN678 |
| B | ILE680 |
| B | TD72001 |
| B | HOH2044 |
| site_id | AC5 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR RESIDUE TD7 C 2001 |
| Chain | Residue |
| C | HIS539 |
| C | ARG540 |
| C | TYR578 |
| C | HIS579 |
| C | SER604 |
| C | HIS605 |
| C | LEU606 |
| C | GLY644 |
| C | ASP645 |
| C | ALA646 |
| C | ALA647 |
| C | ASN678 |
| C | ILE680 |
| C | GLY681 |
| C | HIS747 |
| C | MG2002 |
| C | HOH2033 |
| C | HOH2037 |
| C | HOH2117 |
| C | HOH2118 |
| D | GLN901 |
| D | LEU950 |
| D | GLU952 |
| D | GLN976 |
| D | PHE980 |
| D | HIS1020 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG C 2002 |
| Chain | Residue |
| C | ASP645 |
| C | ASN678 |
| C | ILE680 |
| C | TD72001 |
| C | HOH2033 |
| site_id | AC7 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE TD7 D 2001 |
| Chain | Residue |
| D | PHE506 |
| D | HIS539 |
| D | ARG540 |
| D | TYR578 |
| D | HIS579 |
| D | SER604 |
| D | HIS605 |
| D | LEU606 |
| D | GLY644 |
| D | ASP645 |
| D | ALA646 |
| D | ALA647 |
| D | ASN678 |
| D | ILE680 |
| D | GLY681 |
| D | HIS747 |
| D | MG2002 |
| D | HOH2036 |
| D | HOH2051 |
| D | HOH2116 |
| D | HOH2117 |
| C | GLN901 |
| C | LEU950 |
| C | GLU952 |
| C | GLN976 |
| C | PHE980 |
| C | HIS1020 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG D 2002 |
| Chain | Residue |
| D | ASP645 |
| D | ASN678 |
| D | ILE680 |
| D | TD72001 |
| D | HOH2036 |
| site_id | AC9 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE ACO A 2228 |
| Chain | Residue |
| A | GLU822 |
| A | ILE827 |
| A | GLY1035 |
| A | MET1037 |
| A | THR1038 |
| A | ARG1054 |
| A | ASP1058 |
| A | ILE1060 |
| A | ARG1062 |
| A | SER1092 |
| A | GLN1142 |
| A | PRO1145 |
| A | LEU1146 |
| A | PRO1147 |
| A | ARG1148 |
| A | ARG1149 |
| A | ARG1150 |
| B | PHE590 |
| B | ASP592 |
| site_id | BC1 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE ACO B 2228 |
| Chain | Residue |
| B | GLU822 |
| B | ILE827 |
| B | LYS830 |
| B | GLY1035 |
| B | THR1038 |
| B | ARG1054 |
| B | ASP1058 |
| B | ILE1060 |
| B | ARG1062 |
| B | LYS1089 |
| B | SER1092 |
| B | GLN1142 |
| B | PRO1145 |
| B | LEU1146 |
| B | PRO1147 |
| B | ARG1148 |
| B | ARG1149 |
| B | ARG1150 |
| B | HOH2133 |
| B | HOH2143 |
| C | LYS830 |
| site_id | BC2 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE ACO C 2228 |
| Chain | Residue |
| B | LYS830 |
| C | GLU822 |
| C | ILE827 |
| C | LYS830 |
| C | LEU831 |
| C | GLY1035 |
| C | MET1037 |
| C | THR1038 |
| C | ARG1054 |
| C | ASP1058 |
| C | ARG1062 |
| C | SER1092 |
| C | GLN1142 |
| C | PRO1145 |
| C | LEU1146 |
| C | PRO1147 |
| C | ARG1148 |
| C | ARG1149 |
| C | ARG1150 |
| C | HOH2098 |
| C | HOH2099 |
| C | HOH2119 |
| site_id | BC3 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE ACO D 2228 |
| Chain | Residue |
| D | ILE827 |
| D | THR1038 |
| D | ARG1054 |
| D | ASP1058 |
| D | ILE1060 |
| D | LYS1089 |
| D | SER1092 |
| D | GLN1142 |
| D | PRO1145 |
| D | LEU1146 |
| D | PRO1147 |
| D | ARG1148 |
| D | ARG1149 |
| D | ARG1150 |
| D | HOH2118 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 124 |
| Details | Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 60 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21867916","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2XTA","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21867916","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2Y0P","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
