2XXW

Crystal structure of the GluK2 (GluR6) D776K LBD dimer in complex with glutamate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GLU A 900

Chain	Residue
A	TYR488
A	HOH2085
A	PRO516
A	ALA518
A	ARG523
A	GLY688
A	ALA689
A	THR690
A	GLU738
A	HOH2046

---

site_id	AC2
Number of Residues	13
Details	BINDING SITE FOR RESIDUE GLU B 900

Chain	Residue
B	TYR488
B	PRO516
B	LEU517
B	ALA518
B	ARG523
B	GLY688
B	ALA689
B	THR690
B	GLU738
B	HOH2027
B	HOH2083
B	HOH2084
B	HOH2085

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL B 901

Chain	Residue
B	LYS531
B	ARG775
B	THR779

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15721240","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17115050","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38778115","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"39592599","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1S50","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1S7Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2I0B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2I0C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B36","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B37","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B38","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9B39","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9DXQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9DXR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9DXS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"9DXT","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"15677325","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8163463","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---