2XXA
The Crystal Structure of the Signal Recognition Particle (SRP) in Complex with its Receptor(SR)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003723 | molecular_function | RNA binding |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006612 | biological_process | protein targeting to membrane |
| A | 0006614 | biological_process | SRP-dependent cotranslational protein targeting to membrane |
| A | 0008312 | molecular_function | 7S RNA binding |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016887 | molecular_function | ATP hydrolysis activity |
| A | 0048500 | cellular_component | signal recognition particle |
| A | 1990904 | cellular_component | ribonucleoprotein complex |
| B | 0005525 | molecular_function | GTP binding |
| B | 0006614 | biological_process | SRP-dependent cotranslational protein targeting to membrane |
| B | 0016887 | molecular_function | ATP hydrolysis activity |
| C | 0003723 | molecular_function | RNA binding |
| C | 0003924 | molecular_function | GTPase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005525 | molecular_function | GTP binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006612 | biological_process | protein targeting to membrane |
| C | 0006614 | biological_process | SRP-dependent cotranslational protein targeting to membrane |
| C | 0008312 | molecular_function | 7S RNA binding |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0016887 | molecular_function | ATP hydrolysis activity |
| C | 0048500 | cellular_component | signal recognition particle |
| C | 1990904 | cellular_component | ribonucleoprotein complex |
| D | 0005525 | molecular_function | GTP binding |
| D | 0006614 | biological_process | SRP-dependent cotranslational protein targeting to membrane |
| D | 0016887 | molecular_function | ATP hydrolysis activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR RESIDUE GCP A 600 |
| Chain | Residue |
| A | GLY110 |
| A | GLN147 |
| A | GLY193 |
| A | THR248 |
| A | LYS249 |
| A | ASP251 |
| A | GLY274 |
| A | VAL275 |
| A | GLY276 |
| A | GLU277 |
| A | MG601 |
| A | ALA111 |
| A | HOH2001 |
| A | HOH2002 |
| A | HOH2003 |
| B | ASN107 |
| B | ARG138 |
| B | LEU192 |
| B | GCP600 |
| A | GLY112 |
| A | LYS113 |
| A | THR114 |
| A | THR115 |
| A | LYS119 |
| A | ASP138 |
| A | ARG141 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 601 |
| Chain | Residue |
| A | THR114 |
| A | GCP600 |
| A | HOH2001 |
| A | HOH2002 |
| A | HOH2003 |
| site_id | AC3 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE GCP B 600 |
| Chain | Residue |
| A | GLN109 |
| A | ARG141 |
| A | GCP600 |
| B | ASN107 |
| B | GLY108 |
| B | VAL109 |
| B | GLY110 |
| B | LYS111 |
| B | THR112 |
| B | THR113 |
| B | LYS117 |
| B | ASP135 |
| B | ARG138 |
| B | GLN144 |
| B | GLY190 |
| B | LYS252 |
| B | ASP254 |
| B | GLY277 |
| B | VAL278 |
| B | GLY279 |
| B | GLU280 |
| B | MG601 |
| B | HOH2001 |
| B | HOH2002 |
| B | HOH2003 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 601 |
| Chain | Residue |
| B | THR112 |
| B | ARG138 |
| B | GCP600 |
| B | HOH2001 |
| B | HOH2002 |
| B | HOH2003 |
| site_id | AC5 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR RESIDUE GCP C 600 |
| Chain | Residue |
| C | GLY110 |
| C | ALA111 |
| C | GLY112 |
| C | LYS113 |
| C | THR114 |
| C | THR115 |
| C | LYS119 |
| C | ASP138 |
| C | ARG141 |
| C | GLN147 |
| C | GLY193 |
| C | THR248 |
| C | LYS249 |
| C | ASP251 |
| C | GLY274 |
| C | VAL275 |
| C | GLY276 |
| C | GLU277 |
| C | MG601 |
| C | HOH2001 |
| C | HOH2002 |
| C | HOH2003 |
| D | ASN107 |
| D | ARG138 |
| D | LEU192 |
| D | GCP600 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG C 601 |
| Chain | Residue |
| C | THR114 |
| C | GCP600 |
| C | HOH2001 |
| C | HOH2002 |
| C | HOH2003 |
| site_id | AC7 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR RESIDUE GCP D 600 |
| Chain | Residue |
| D | VAL109 |
| D | GLY110 |
| D | LYS111 |
| D | THR112 |
| D | THR113 |
| D | LYS117 |
| D | ASP135 |
| D | ARG138 |
| D | GLN144 |
| D | GLY190 |
| D | LYS252 |
| D | ASP254 |
| D | GLY277 |
| D | VAL278 |
| D | GLY279 |
| D | GLU280 |
| D | MG601 |
| D | HOH2001 |
| D | HOH2002 |
| D | HOH2003 |
| C | GLN109 |
| C | ARG141 |
| C | LEU195 |
| C | GCP600 |
| D | ASN107 |
| D | GLY108 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG D 601 |
| Chain | Residue |
| D | THR112 |
| D | ARG138 |
| D | GCP600 |
| D | HOH2001 |
| D | HOH2002 |
| D | HOH2003 |
Functional Information from PROSITE/UniProt
| site_id | PS00300 |
| Number of Residues | 14 |
| Details | SRP54 SRP54-type proteins GTP-binding domain signature. PIrYIGVGErIedL |
| Chain | Residue | Details |
| B | PRO272-LEU285 | |
| A | PRO269-LEU282 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00920 |
| Chain | Residue | Details |
| B | GLY105 | |
| B | ASP187 | |
| B | THR251 | |
| D | GLY105 | |
| D | ASP187 | |
| D | THR251 |
