2XWQ
Anaerobic cobalt chelatase from Archeaoglobus fulgidus (CbiX) in complex with metalated sirohydrochlorin product
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0009236 | biological_process | cobalamin biosynthetic process |
| A | 0016829 | molecular_function | lyase activity |
| A | 0016852 | molecular_function | sirohydrochlorin cobaltochelatase activity |
| A | 0019251 | biological_process | anaerobic cobalamin biosynthetic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0046906 | molecular_function | tetrapyrrole binding |
| A | 0050897 | molecular_function | cobalt ion binding |
| B | 0009236 | biological_process | cobalamin biosynthetic process |
| B | 0016829 | molecular_function | lyase activity |
| B | 0016852 | molecular_function | sirohydrochlorin cobaltochelatase activity |
| B | 0019251 | biological_process | anaerobic cobalamin biosynthetic process |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0046906 | molecular_function | tetrapyrrole binding |
| B | 0050897 | molecular_function | cobalt ion binding |
| C | 0009236 | biological_process | cobalamin biosynthetic process |
| C | 0016829 | molecular_function | lyase activity |
| C | 0016852 | molecular_function | sirohydrochlorin cobaltochelatase activity |
| C | 0019251 | biological_process | anaerobic cobalamin biosynthetic process |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0046906 | molecular_function | tetrapyrrole binding |
| C | 0050897 | molecular_function | cobalt ion binding |
| D | 0009236 | biological_process | cobalamin biosynthetic process |
| D | 0016829 | molecular_function | lyase activity |
| D | 0016852 | molecular_function | sirohydrochlorin cobaltochelatase activity |
| D | 0019251 | biological_process | anaerobic cobalamin biosynthetic process |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0046906 | molecular_function | tetrapyrrole binding |
| D | 0050897 | molecular_function | cobalt ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 29 |
| Details | BINDING SITE FOR RESIDUE SIR B 1126 |
| Chain | Residue |
| A | HIS10 |
| A | GLY72 |
| A | LEU73 |
| A | HIS74 |
| A | HOH2005 |
| A | HOH2025 |
| B | HIS10 |
| B | GLY11 |
| B | SER12 |
| B | ARG44 |
| B | ARG46 |
| A | GLY11 |
| B | PHE68 |
| B | ILE69 |
| B | SER70 |
| B | GLY72 |
| B | LEU73 |
| B | HIS74 |
| B | HOH2056 |
| B | HOH2057 |
| B | HOH2058 |
| B | HOH2059 |
| A | SER12 |
| A | GLN13 |
| A | ARG44 |
| A | ARG46 |
| A | PHE68 |
| A | ILE69 |
| A | SER70 |
| site_id | AC2 |
| Number of Residues | 28 |
| Details | BINDING SITE FOR RESIDUE SIR D 1126 |
| Chain | Residue |
| C | HIS10 |
| C | SER12 |
| C | GLN13 |
| C | TYR17 |
| C | ARG44 |
| C | ARG46 |
| C | ARG47 |
| C | ARG55 |
| C | PHE68 |
| C | ILE69 |
| C | SER70 |
| C | GLY72 |
| C | LEU73 |
| C | HIS74 |
| D | HIS10 |
| D | SER12 |
| D | TYR17 |
| D | ARG44 |
| D | ARG46 |
| D | PHE68 |
| D | ILE69 |
| D | SER70 |
| D | GLY72 |
| D | LEU73 |
| D | HIS74 |
| D | HOH2047 |
| D | HOH2048 |
| D | HOH2049 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|HAMAP-Rule:MF_00785, ECO:0000305|PubMed:21173279 |
| Chain | Residue | Details |
| A | HIS10 | |
| B | HIS10 | |
| C | HIS10 | |
| D | HIS10 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00785, ECO:0000305|PubMed:16835730, ECO:0000305|PubMed:21173279 |
| Chain | Residue | Details |
| A | HIS10 | |
| A | HIS74 | |
| B | HIS10 | |
| B | HIS74 | |
| C | HIS10 | |
| C | HIS74 | |
| D | HIS10 | |
| D | HIS74 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00785, ECO:0000269|PubMed:21173279, ECO:0007744|PDB:2XWQ |
| Chain | Residue | Details |
| A | ARG46 | |
| A | ILE69 | |
| B | ARG46 | |
| B | ILE69 | |
| C | ARG46 | |
| C | ILE69 | |
| D | ARG46 | |
| D | ILE69 |
