2XVX
Cobalt chelatase CbiK (periplasmatic) from Desulvobrio vulgaris Hildenborough (Native)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016829 | molecular_function | lyase activity |
| A | 0016852 | molecular_function | sirohydrochlorin cobaltochelatase activity |
| A | 0019251 | biological_process | anaerobic cobalamin biosynthetic process |
| A | 0020037 | molecular_function | heme binding |
| A | 0042597 | cellular_component | periplasmic space |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0050897 | molecular_function | cobalt ion binding |
| A | 0051262 | biological_process | protein tetramerization |
| A | 0051266 | molecular_function | sirohydrochlorin ferrochelatase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE HEM A 1270 |
| Chain | Residue |
| A | PRO91 |
| A | LEU119 |
| A | HIS158 |
| A | PRO159 |
| A | HOH2070 |
| A | HOH2200 |
| A | PRO91 |
| A | GLU93 |
| A | HIS96 |
| A | HIS96 |
| A | LEU99 |
| A | LEU99 |
| A | GLU100 |
| A | HIS103 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1271 |
| Chain | Residue |
| A | GLY92 |
| A | GLU93 |
| A | GLU94 |
| A | THR156 |
| A | HIS158 |
| A | HOH2069 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1272 |
| Chain | Residue |
| A | HIS103 |
| A | ARG114 |
| A | VAL115 |
| A | SER116 |
| A | VAL117 |
| A | ARG267 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1273 |
| Chain | Residue |
| A | LEU87 |
| A | HIS88 |
| A | THR89 |
| A | HIS154 |
| A | MET210 |
| A | ALA211 |
| A | NA1288 |
| A | HOH2202 |
| A | HOH2203 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1274 |
| Chain | Residue |
| A | PRO43 |
| A | VAL44 |
| A | ARG45 |
| A | HOH2204 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1275 |
| Chain | Residue |
| A | THR19 |
| A | SER20 |
| A | VAL21 |
| A | ILE53 |
| A | GLY214 |
| A | ASP215 |
| A | GOL1284 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 1276 |
| Chain | Residue |
| A | VAL136 |
| A | ARG143 |
| A | ASP175 |
| A | ASP197 |
| A | ARG236 |
| A | HOH2206 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL A 1277 |
| Chain | Residue |
| A | THR49 |
| A | LYS51 |
| A | MET52 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 1278 |
| Chain | Residue |
| A | LYS144 |
| A | ARG203 |
| A | GOL1279 |
| A | HOH2111 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 1279 |
| Chain | Residue |
| A | LYS144 |
| A | ARG203 |
| A | GLU239 |
| A | GOL1278 |
| A | HOH2209 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 1280 |
| Chain | Residue |
| A | GOL1285 |
| A | HOH2210 |
| A | HOH2211 |
| A | HOH2212 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 1281 |
| Chain | Residue |
| A | PRO176 |
| A | ASP197 |
| A | VAL198 |
| A | HOH2206 |
| A | HOH2213 |
| site_id | BC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL A 1282 |
| Chain | Residue |
| A | SER250 |
| A | ASP251 |
| A | ALA252 |
| site_id | BC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GOL A 1283 |
| Chain | Residue |
| A | PRO176 |
| A | ARG199 |
| site_id | BC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 1284 |
| Chain | Residue |
| A | PHE17 |
| A | HIS154 |
| A | GLY214 |
| A | ASP215 |
| A | HIS216 |
| A | SO41275 |
| site_id | BC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 1285 |
| Chain | Residue |
| A | ARG58 |
| A | ARG58 |
| A | ILE62 |
| A | GOL1280 |
| A | HOH2214 |
| A | HOH2214 |
| A | HOH2215 |
| site_id | BC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CO2 A 1286 |
| Chain | Residue |
| A | GLU184 |
| A | HIS216 |
| A | HOH2217 |
| site_id | BC9 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL A 1287 |
| Chain | Residue |
| A | ALA141 |
| site_id | CC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA A 1288 |
| Chain | Residue |
| A | SO41273 |
| A | THR89 |
| A | GLY153 |
| A | HIS154 |
| A | TYR164 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"21173279","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Binding site: {"description":"axial binding residue","evidences":[{"source":"PubMed","id":"21173279","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2XVX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2XVZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21173279","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2XVZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
