2XVB

Crystal structure of Laccase from Thermus thermophilus HB27 complexed with Hg, crystal of the apoenzyme soaked for 5 min. in 5 mM HgCl2 at 278 K.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005507	molecular_function	copper ion binding
A	0016491	molecular_function	oxidoreductase activity
A	0030288	cellular_component	outer membrane-bounded periplasmic space
A	0046872	molecular_function	metal ion binding
A	0052716	molecular_function	hydroquinone:oxygen oxidoreductase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE HG A 1463

Chain	Residue
A	HIS393
A	CYS445
A	HIS450
A	MET455

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE HG A 1464

Chain	Residue
A	HIS97
A	TRP133
A	HIS135
A	HIS446
A	HOH2434

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE HG A 1465

Chain	Residue
A	HIS95
A	HIS97
A	HIS396
A	HIS398

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE HG A 1466

Chain	Residue
A	HIS137
A	HIS398
A	HIS444
A	HOH2156
A	HOH2434

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE HG A 1467

Chain	Residue
A	MET296
A	MET301
A	HIS303
A	MET305

---

site_id	AC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE MPD A 1468

Chain	Residue
A	ALA247
A	ASP248
A	LEU263
A	GLU267
A	ARG268
A	TYR414
A	LYS418
A	MPD1479

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MPD A 1469

Chain	Residue
A	ARG280
A	TYR317
A	HOH2440
A	HOH2442
A	HOH2443

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MRD A 1470

Chain	Residue
A	GLN56
A	LEU339
A	HOH2055
A	HOH2444

---

site_id	AC9
Number of Residues	9
Details	BINDING SITE FOR RESIDUE MRD A 1471

Chain	Residue
A	PRO342
A	PRO342
A	VAL343
A	VAL343
A	VAL344
A	VAL344
A	THR345
A	THR345
A	HOH2338

---

site_id	BC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MPD A 1472

Chain	Residue
A	ARG75
A	PRO76
A	GLU157
A	SER158
A	SER159
A	HOH2173
A	HOH2445

---

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MPD A 1473

Chain	Residue
A	GLY140
A	TRP194
A	ARG453
A	MPD1474
A	MPD1482

---

site_id	BC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE MPD A 1474

Chain	Residue
A	PRO144
A	PRO188
A	HIS189
A	TRP194
A	MPD1473
A	HOH2160
A	HOH2198
A	HOH2446

---

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MPD A 1475

Chain	Residue
A	GLY64
A	PRO70
A	HOH2068
A	HOH2448

---

site_id	BC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE MRD A 1476

Chain	Residue
A	PRO28
A	GLU29
A	PHE67
A	ASN206
A	HOH2047
A	HOH2070
A	HOH2072
A	HOH2449

---

site_id	BC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE MPD A 1477

Chain	Residue
A	PRO25
A	SER26
A	GLN216
A	ASN362
A	GLN364
A	HOH2004
A	HOH2006
A	HOH2450

---

site_id	BC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE MRD A 1478

Chain	Residue
A	ASP289
A	GLY291
A	ASP390
A	MET391
A	ASP392
A	LYS424
A	ALA425
A	HOH2390
A	HOH2414

---

site_id	BC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MPD A 1479

Chain	Residue
A	LEU261
A	MPD1468
A	HOH2452
A	LEU256
A	GLU260

---

site_id	BC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MPD A 1480

Chain	Residue
A	GLU127
A	LEU128
A	SER158
A	SER159
A	SER334
A	HOH2453

---

site_id	CC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MPD A 1481

Chain	Residue
A	PRO241
A	GLU257
A	MRD1483
A	HOH2262
A	HOH2454

---

site_id	CC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MPD A 1482

Chain	Residue
A	PRO191
A	MPD1473

---

site_id	CC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE MRD A 1483

Chain	Residue
A	HIS240
A	PRO241
A	SER259
A	ARG276
A	MPD1481
A	HOH2242
A	HOH2264
A	HOH2455

---

site_id	CC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MRD A 1484

Chain	Residue
A	MET192
A	MET195
A	MET354
A	MET355

---

Functional Information from PROSITE/UniProt

site_id	PS00080
Number of Residues	12
Details	MULTICOPPER_OXIDASE2 Multicopper oxidases signature 2. HCHiveHedrGM

Chain	Residue	Details
A	HIS444-MET455

---