Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2XTZ

Crystal structure of the G alpha protein AtGPA1 from Arabidopsis thaliana

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0001664	molecular_function	G protein-coupled receptor binding
A	0003376	biological_process	sphingosine-1-phosphate receptor signaling pathway
A	0003924	molecular_function	GTPase activity
A	0005095	molecular_function	GTPase inhibitor activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005737	cellular_component	cytoplasm
A	0005777	cellular_component	peroxisome
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005834	cellular_component	heterotrimeric G-protein complex
A	0005886	cellular_component	plasma membrane
A	0006571	biological_process	L-tyrosine biosynthetic process
A	0007165	biological_process	signal transduction
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0007188	biological_process	adenylate cyclase-modulating G protein-coupled receptor signaling pathway
A	0009094	biological_process	L-phenylalanine biosynthetic process
A	0009506	cellular_component	plasmodesma
A	0009738	biological_process	abscisic acid-activated signaling pathway
A	0009740	biological_process	gibberellic acid mediated signaling pathway
A	0009749	biological_process	response to glucose
A	0009785	biological_process	blue light signaling pathway
A	0009789	biological_process	positive regulation of abscisic acid-activated signaling pathway
A	0009845	biological_process	seed germination
A	0010027	biological_process	thylakoid membrane organization
A	0010119	biological_process	regulation of stomatal movement
A	0010244	biological_process	response to low fluence blue light stimulus by blue low-fluence system
A	0010476	biological_process	gibberellin mediated signaling pathway
A	0016247	molecular_function	channel regulator activity
A	0016787	molecular_function	hydrolase activity
A	0019001	molecular_function	guanyl nucleotide binding
A	0019236	biological_process	response to pheromone
A	0031683	molecular_function	G-protein beta/gamma-subunit complex binding
A	0042127	biological_process	regulation of cell population proliferation
A	0046872	molecular_function	metal ion binding
A	0051020	molecular_function	GTPase binding
A	0072593	biological_process	reactive oxygen species metabolic process
A	0090333	biological_process	regulation of stomatal closure
A	0097468	biological_process	programmed cell death in response to reactive oxygen species
B	0000166	molecular_function	nucleotide binding
B	0001664	molecular_function	G protein-coupled receptor binding
B	0003376	biological_process	sphingosine-1-phosphate receptor signaling pathway
B	0003924	molecular_function	GTPase activity
B	0005095	molecular_function	GTPase inhibitor activity
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0005737	cellular_component	cytoplasm
B	0005777	cellular_component	peroxisome
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0005834	cellular_component	heterotrimeric G-protein complex
B	0005886	cellular_component	plasma membrane
B	0006571	biological_process	L-tyrosine biosynthetic process
B	0007165	biological_process	signal transduction
B	0007186	biological_process	G protein-coupled receptor signaling pathway
B	0007188	biological_process	adenylate cyclase-modulating G protein-coupled receptor signaling pathway
B	0009094	biological_process	L-phenylalanine biosynthetic process
B	0009506	cellular_component	plasmodesma
B	0009738	biological_process	abscisic acid-activated signaling pathway
B	0009740	biological_process	gibberellic acid mediated signaling pathway
B	0009749	biological_process	response to glucose
B	0009785	biological_process	blue light signaling pathway
B	0009789	biological_process	positive regulation of abscisic acid-activated signaling pathway
B	0009845	biological_process	seed germination
B	0010027	biological_process	thylakoid membrane organization
B	0010119	biological_process	regulation of stomatal movement
B	0010244	biological_process	response to low fluence blue light stimulus by blue low-fluence system
B	0010476	biological_process	gibberellin mediated signaling pathway
B	0016247	molecular_function	channel regulator activity
B	0016787	molecular_function	hydrolase activity
B	0019001	molecular_function	guanyl nucleotide binding
B	0019236	biological_process	response to pheromone
B	0031683	molecular_function	G-protein beta/gamma-subunit complex binding
B	0042127	biological_process	regulation of cell population proliferation
B	0046872	molecular_function	metal ion binding
B	0051020	molecular_function	GTPase binding
B	0072593	biological_process	reactive oxygen species metabolic process
B	0090333	biological_process	regulation of stomatal closure
B	0097468	biological_process	programmed cell death in response to reactive oxygen species
C	0000166	molecular_function	nucleotide binding
C	0001664	molecular_function	G protein-coupled receptor binding
C	0003376	biological_process	sphingosine-1-phosphate receptor signaling pathway
C	0003924	molecular_function	GTPase activity
C	0005095	molecular_function	GTPase inhibitor activity
C	0005515	molecular_function	protein binding
C	0005525	molecular_function	GTP binding
C	0005737	cellular_component	cytoplasm
C	0005777	cellular_component	peroxisome
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0005834	cellular_component	heterotrimeric G-protein complex
C	0005886	cellular_component	plasma membrane
C	0006571	biological_process	L-tyrosine biosynthetic process
C	0007165	biological_process	signal transduction
C	0007186	biological_process	G protein-coupled receptor signaling pathway
C	0007188	biological_process	adenylate cyclase-modulating G protein-coupled receptor signaling pathway
C	0009094	biological_process	L-phenylalanine biosynthetic process
C	0009506	cellular_component	plasmodesma
C	0009738	biological_process	abscisic acid-activated signaling pathway
C	0009740	biological_process	gibberellic acid mediated signaling pathway
C	0009749	biological_process	response to glucose
C	0009785	biological_process	blue light signaling pathway
C	0009789	biological_process	positive regulation of abscisic acid-activated signaling pathway
C	0009845	biological_process	seed germination
C	0010027	biological_process	thylakoid membrane organization
C	0010119	biological_process	regulation of stomatal movement
C	0010244	biological_process	response to low fluence blue light stimulus by blue low-fluence system
C	0010476	biological_process	gibberellin mediated signaling pathway
C	0016247	molecular_function	channel regulator activity
C	0016787	molecular_function	hydrolase activity
C	0019001	molecular_function	guanyl nucleotide binding
C	0019236	biological_process	response to pheromone
C	0031683	molecular_function	G-protein beta/gamma-subunit complex binding
C	0042127	biological_process	regulation of cell population proliferation
C	0046872	molecular_function	metal ion binding
C	0051020	molecular_function	GTPase binding
C	0072593	biological_process	reactive oxygen species metabolic process
C	0090333	biological_process	regulation of stomatal closure
C	0097468	biological_process	programmed cell death in response to reactive oxygen species

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 1381

Chain	Residue
A	SER52
A	THR193
A	GSP1382
A	HOH2042
A	HOH2049

site_id	AC2
Number of Residues	27
Details	BINDING SITE FOR RESIDUE GSP A 1382

Chain	Residue
A	LYS51
A	SER52
A	THR53
A	LEU187
A	TYR188
A	ARG190
A	THR193
A	GLY220
A	GLY221
A	ASN287
A	LYS288
A	ASP290
A	ILE291
A	THR354
A	ALA355
A	LEU356
A	MG1381
A	HOH2042
A	HOH2045
A	HOH2049
A	HOH2135
A	HOH2137
A	HOH2138
A	GLY47
A	GLU48
A	SER49
A	GLY50

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG B 1378

Chain	Residue
B	SER52
B	THR193
B	GSP1379
B	HOH2006
B	HOH2011

site_id	AC4
Number of Residues	25
Details	BINDING SITE FOR RESIDUE GSP B 1379

Chain	Residue
B	GLY47
B	GLU48
B	SER49
B	GLY50
B	LYS51
B	SER52
B	THR53
B	ASP162
B	LEU187
B	TYR188
B	ARG190
B	THR193
B	GLY220
B	GLY221
B	ASN287
B	LYS288
B	ASP290
B	ILE291
B	THR354
B	ALA355
B	LEU356
B	MG1378
B	HOH2005
B	HOH2006
B	HOH2011

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG C 1381

Chain	Residue
C	SER52
C	THR193
C	GSP1382
C	HOH2004
C	HOH2039

site_id	AC6
Number of Residues	23
Details	BINDING SITE FOR RESIDUE GSP C 1382

Chain	Residue
C	GLY47
C	GLU48
C	SER49
C	GLY50
C	LYS51
C	SER52
C	THR53
C	LEU187
C	TYR188
C	ARG190
C	THR193
C	GLY220
C	GLY221
C	ASN287
C	LYS288
C	ASP290
C	ILE291
C	THR354
C	ALA355
C	LEU356
C	MG1381
C	HOH2004
C	HOH2039

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL B 1380

Chain	Residue
B	ARG130
B	LEU131

site_id	AC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 1383

Chain	Residue
A	LYS349

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 C 1383

Chain	Residue
C	LYS349
C	THR371
C	ARG374

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 1384

Chain	Residue
A	VAL191
A	ARG192
A	HOH2139

site_id	BC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 C 1384

Chain	Residue
C	VAL191
C	ARG192
C	HOH2041

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 1381

Chain	Residue
B	ARG190
B	VAL191
B	ARG192

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 1385

Chain	Residue
B	THR182
B	LYS183
C	GLY316
C	LYS317

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	39
Details	Region: {"description":"G1 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	24
Details	Region: {"description":"G2 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	27
Details	Region: {"description":"G3 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	21
Details	Region: {"description":"G4 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	15
Details	Region: {"description":"G5 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01230","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	45
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21304159","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2XTZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)