2XTV

Structure of E.coli rhomboid protease GlpG, active site mutant, S201T, orthorhombic crystal form

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004252	molecular_function	serine-type endopeptidase activity
A	0006508	biological_process	proteolysis
A	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE MC3 A 501

Chain	Residue
A	THR130
A	MC3505
A	HOH2076
A	PHE133
A	GLU134
A	PHE135
A	TRP136
A	ARG217
A	ALA263
A	PHE266
A	MC3503

---

site_id	AC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE MC3 A 502

Chain	Residue
A	TRP122
A	PHE153
A	LEU156
A	TRP157
A	TRP159
A	TYR160
A	GLN226
A	PHE232
A	PHE245
A	HOH2077

---

site_id	AC3
Number of Residues	11
Details	BINDING SITE FOR RESIDUE MC3 A 503

Chain	Residue
A	TRP136
A	PHE153
A	LEU155
A	LEU156
A	TRP159
A	PHE266
A	LEU270
A	MC3501
A	MC3509
A	MC3511
A	HOH2079

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MC3 A 504

Chain	Residue
A	LEU184
A	ALA256
A	ALA263
A	MC3512

---

site_id	AC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE MC3 A 505

Chain	Residue
A	LYS132
A	TYR138
A	TRP212
A	GLU216
A	MC3501
A	MC3506
A	MC3507
A	MC3508

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MC3 A 506

Chain	Residue
A	VAL106
A	ILE109
A	LEU234
A	MC3505
A	MC3508
A	MC3512

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MC3 A 507

Chain	Residue
A	TRP125
A	LEU183
A	GLN190
A	MC3505
A	MC3508

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MC3 A 508

Chain	Residue
A	TYR187
A	MC3505
A	MC3506
A	MC3507

---

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MC3 A 509

Chain	Residue
A	PHE139
A	ILE175
A	LEU179
A	MC3503
A	MC3510

---

site_id	BC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MC3 A 510

Chain	Residue
A	MC3509

---

site_id	BC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MC3 A 511

Chain	Residue
A	GLN112
A	MC3503
A	MC3512

---

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MC3 A 512

Chain	Residue
A	TYR187
A	MC3504
A	MC3506
A	MC3511

---

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MC3 A 513

Chain	Residue
A	PHE242
A	VAL267
A	ASN271

---

site_id	BC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MC3 A 514

Chain	Residue
A	ILE102
A	PHE242
A	ASP243

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	27
Details	Topological domain: {"description":"Periplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	14
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	22
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	22
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"17051161","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"17099694","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"17190827","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"17277078","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	Active site: {"evidences":[{"source":"PubMed","id":"17051161","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"17099694","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"17190827","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"17277078","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---