Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000015 | cellular_component | phosphopyruvate hydratase complex |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0004634 | molecular_function | phosphopyruvate hydratase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006094 | biological_process | gluconeogenesis |
| A | 0006096 | biological_process | glycolytic process |
| A | 0016020 | cellular_component | membrane |
| A | 0016829 | molecular_function | lyase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0061621 | biological_process | canonical glycolysis |
| A | 0070062 | cellular_component | extracellular exosome |
| B | 0000015 | cellular_component | phosphopyruvate hydratase complex |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0004634 | molecular_function | phosphopyruvate hydratase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005615 | cellular_component | extracellular space |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006094 | biological_process | gluconeogenesis |
| B | 0006096 | biological_process | glycolytic process |
| B | 0016020 | cellular_component | membrane |
| B | 0016829 | molecular_function | lyase activity |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0061621 | biological_process | canonical glycolysis |
| B | 0070062 | cellular_component | extracellular exosome |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 500 |
| Chain | Residue |
| A | ASP245 |
| A | GLU293 |
| A | ASP318 |
| A | HOH2267 |
| A | HOH2358 |
| A | HOH2506 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 A 501 |
| Chain | Residue |
| A | SER373 |
| A | HOH2506 |
| A | HOH2542 |
| A | HOH2543 |
| A | GLU210 |
| A | LYS343 |
| A | ARG372 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 502 |
| Chain | Residue |
| A | LYS193 |
| A | THR205 |
| A | VAL207 |
| A | HOH2544 |
| B | ASP209 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 503 |
| Chain | Residue |
| A | LYS202 |
| A | ASP203 |
| A | ALA204 |
| A | THR205 |
| A | ASN206 |
| B | GLY160 |
| B | HOH2301 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 504 |
| Chain | Residue |
| A | GLU219 |
| A | ASN220 |
| A | ASN221 |
| A | HOH2545 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE EDO A 505 |
| Chain | Residue |
| A | GLY273 |
| A | GLU274 |
| A | GLY277 |
| A | PHE296 |
| A | THR303 |
| A | SER306 |
| A | PHE307 |
| A | HOH2396 |
| A | HOH2546 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 506 |
| Chain | Residue |
| A | GLU180 |
| A | ARG183 |
| A | ILE184 |
| A | TYR236 |
| A | HOH2547 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO A 507 |
| Chain | Residue |
| A | LYS202 |
| A | GLY310 |
| A | VAL311 |
| A | ASN312 |
| A | EDO508 |
| A | HOH2548 |
| B | PHE261 |
| B | LYS262 |
| site_id | AC9 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE EDO A 508 |
| Chain | Residue |
| A | LYS202 |
| A | VAL311 |
| A | ASN312 |
| A | EDO507 |
| A | HOH2549 |
| A | HOH2550 |
| B | LYS262 |
| B | SER263 |
| B | PRO264 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 509 |
| Chain | Residue |
| A | ALA302 |
| A | HOH2288 |
| A | HOH2553 |
| A | HOH2554 |
| A | HOH2555 |
| B | LEU58 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 510 |
| Chain | Residue |
| A | ASN338 |
| A | HOH2462 |
| A | HOH2556 |
| A | HOH2557 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 511 |
| Chain | Residue |
| A | GLU21 |
| A | ARG32 |
| A | ASP378 |
| A | HOH2558 |
| site_id | BC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 500 |
| Chain | Residue |
| B | ASP245 |
| B | GLU293 |
| B | ASP318 |
| B | HOH2254 |
| B | HOH2336 |
| B | HOH2514 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PO4 B 501 |
| Chain | Residue |
| B | GLU210 |
| B | LYS343 |
| B | ARG372 |
| B | SER373 |
| B | HOH2514 |
| site_id | BC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO B 502 |
| Chain | Residue |
| A | GLY160 |
| A | HOH2318 |
| B | LYS202 |
| B | ASP203 |
| B | ALA204 |
| B | THR205 |
| B | ASN206 |
| site_id | BC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 503 |
| Chain | Residue |
| B | GLU219 |
| B | ASN220 |
| B | ASN221 |
| B | HOH2515 |
| site_id | BC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO B 504 |
| Chain | Residue |
| B | EDO510 |
| B | HOH2516 |
| B | HOH2517 |
| B | HOH2518 |
| B | HIS191 |
| B | GLY194 |
| B | VAL195 |
| site_id | BC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO B 505 |
| Chain | Residue |
| A | GLU10 |
| A | HOH2015 |
| A | HOH2017 |
| B | LYS179 |
| B | GLU415 |
| B | HOH2264 |
| site_id | CC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 506 |
| Chain | Residue |
| A | ASP209 |
| B | LYS193 |
| B | THR205 |
| B | ASN206 |
| B | HOH2519 |
| site_id | CC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO B 507 |
| Chain | Residue |
| B | ASP142 |
| B | LEU143 |
| B | ILE144 |
| B | ILE422 |
| B | HOH2492 |
| B | HOH2520 |
| B | HOH2521 |
| site_id | CC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO B 508 |
| Chain | Residue |
| B | GLU274 |
| B | PHE307 |
| B | HOH2522 |
| site_id | CC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 509 |
| Chain | Residue |
| B | GLU180 |
| B | ARG183 |
| B | TYR236 |
| B | HOH2334 |
| B | HOH2523 |
| site_id | CC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO B 510 |
| Chain | Residue |
| A | LEU58 |
| B | GLY194 |
| B | EDO504 |
Functional Information from PROSITE/UniProt
| site_id | PS00164 |
| Number of Residues | 14 |
| Details | ENOLASE Enolase signature. LLLKvNQIGSVTES |
| Chain | Residue | Details |
| A | LEU340-SER353 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P15429","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P15429","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P15429","evidenceCode":"ECO:0000250"}]} |
