2XSH
CRYSTAL STRUCTURE OF P4 VARIANT OF BIPHENYL DIOXYGENASE FROM BURKHOLDERIA XENOVORANS LB400 IN COMPLEX WITH 2,6 DI CHLOROBIPHENYL
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005506 | molecular_function | iron ion binding |
A | 0009056 | biological_process | catabolic process |
A | 0018687 | molecular_function | biphenyl 2,3-dioxygenase activity |
A | 0044237 | biological_process | cellular metabolic process |
A | 0046872 | molecular_function | metal ion binding |
A | 0051213 | molecular_function | dioxygenase activity |
A | 0051537 | molecular_function | 2 iron, 2 sulfur cluster binding |
B | 0009056 | biological_process | catabolic process |
B | 0018687 | molecular_function | biphenyl 2,3-dioxygenase activity |
B | 0019380 | biological_process | 3-phenylpropionate catabolic process |
B | 0051213 | molecular_function | dioxygenase activity |
C | 0005506 | molecular_function | iron ion binding |
C | 0009056 | biological_process | catabolic process |
C | 0018687 | molecular_function | biphenyl 2,3-dioxygenase activity |
C | 0044237 | biological_process | cellular metabolic process |
C | 0046872 | molecular_function | metal ion binding |
C | 0051213 | molecular_function | dioxygenase activity |
C | 0051537 | molecular_function | 2 iron, 2 sulfur cluster binding |
D | 0009056 | biological_process | catabolic process |
D | 0018687 | molecular_function | biphenyl 2,3-dioxygenase activity |
D | 0019380 | biological_process | 3-phenylpropionate catabolic process |
D | 0051213 | molecular_function | dioxygenase activity |
E | 0005506 | molecular_function | iron ion binding |
E | 0009056 | biological_process | catabolic process |
E | 0018687 | molecular_function | biphenyl 2,3-dioxygenase activity |
E | 0044237 | biological_process | cellular metabolic process |
E | 0046872 | molecular_function | metal ion binding |
E | 0051213 | molecular_function | dioxygenase activity |
E | 0051537 | molecular_function | 2 iron, 2 sulfur cluster binding |
F | 0009056 | biological_process | catabolic process |
F | 0018687 | molecular_function | biphenyl 2,3-dioxygenase activity |
F | 0019380 | biological_process | 3-phenylpropionate catabolic process |
F | 0051213 | molecular_function | dioxygenase activity |
G | 0005506 | molecular_function | iron ion binding |
G | 0009056 | biological_process | catabolic process |
G | 0018687 | molecular_function | biphenyl 2,3-dioxygenase activity |
G | 0044237 | biological_process | cellular metabolic process |
G | 0046872 | molecular_function | metal ion binding |
G | 0051213 | molecular_function | dioxygenase activity |
G | 0051537 | molecular_function | 2 iron, 2 sulfur cluster binding |
H | 0009056 | biological_process | catabolic process |
H | 0018687 | molecular_function | biphenyl 2,3-dioxygenase activity |
H | 0019380 | biological_process | 3-phenylpropionate catabolic process |
H | 0051213 | molecular_function | dioxygenase activity |
I | 0005506 | molecular_function | iron ion binding |
I | 0009056 | biological_process | catabolic process |
I | 0018687 | molecular_function | biphenyl 2,3-dioxygenase activity |
I | 0044237 | biological_process | cellular metabolic process |
I | 0046872 | molecular_function | metal ion binding |
I | 0051213 | molecular_function | dioxygenase activity |
I | 0051537 | molecular_function | 2 iron, 2 sulfur cluster binding |
J | 0009056 | biological_process | catabolic process |
J | 0018687 | molecular_function | biphenyl 2,3-dioxygenase activity |
J | 0019380 | biological_process | 3-phenylpropionate catabolic process |
J | 0051213 | molecular_function | dioxygenase activity |
K | 0005506 | molecular_function | iron ion binding |
K | 0009056 | biological_process | catabolic process |
K | 0018687 | molecular_function | biphenyl 2,3-dioxygenase activity |
K | 0044237 | biological_process | cellular metabolic process |
K | 0046872 | molecular_function | metal ion binding |
K | 0051213 | molecular_function | dioxygenase activity |
K | 0051537 | molecular_function | 2 iron, 2 sulfur cluster binding |
L | 0009056 | biological_process | catabolic process |
L | 0018687 | molecular_function | biphenyl 2,3-dioxygenase activity |
L | 0019380 | biological_process | 3-phenylpropionate catabolic process |
L | 0051213 | molecular_function | dioxygenase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE FES A 900 |
Chain | Residue |
A | CYS100 |
A | HIS102 |
A | ARG103 |
A | CYS120 |
A | HIS123 |
A | TRP125 |
site_id | AC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE FE2 A 901 |
Chain | Residue |
A | ASP388 |
A | HOH2109 |
A | GLN226 |
A | HIS233 |
A | HIS239 |
site_id | AC3 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE DC5 A 902 |
Chain | Residue |
A | GLN226 |
A | ASP230 |
A | MET231 |
A | HIS233 |
A | HIS239 |
A | SER283 |
A | GLN322 |
A | HIS323 |
A | LEU333 |
A | PHE384 |
site_id | AC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE FES C 900 |
Chain | Residue |
C | CYS100 |
C | HIS102 |
C | ARG103 |
C | CYS120 |
C | HIS123 |
C | TRP125 |
site_id | AC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE FE2 C 901 |
Chain | Residue |
C | GLN226 |
C | HIS233 |
C | HIS239 |
C | ASP388 |
C | HOH2073 |
site_id | AC6 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE DC5 C 902 |
Chain | Residue |
C | GLN226 |
C | ASP230 |
C | MET231 |
C | HIS233 |
C | ALA234 |
C | HIS239 |
C | GLN322 |
C | HIS323 |
C | LEU333 |
C | PHE384 |
C | HOH2073 |
site_id | AC7 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE DC5 E 900 |
Chain | Residue |
E | GLN226 |
E | ASP230 |
E | MET231 |
E | HIS233 |
E | ALA234 |
E | HIS239 |
E | GLN322 |
E | HIS323 |
E | LEU333 |
E | MET336 |
E | PHE384 |
site_id | AC8 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE FES E 901 |
Chain | Residue |
E | CYS100 |
E | HIS102 |
E | ARG103 |
E | MET105 |
E | CYS120 |
E | HIS123 |
E | TRP125 |
site_id | AC9 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE FE2 E 902 |
Chain | Residue |
E | GLN226 |
E | HIS233 |
E | HIS239 |
E | ASP388 |
E | HOH2101 |
site_id | BC1 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE FES G 900 |
Chain | Residue |
G | CYS100 |
G | HIS102 |
G | ARG103 |
G | CYS120 |
G | HIS123 |
G | TRP125 |
G | HOH2019 |
G | HOH2023 |
site_id | BC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE FE2 G 901 |
Chain | Residue |
G | GLN226 |
G | HIS233 |
G | HIS239 |
G | ASP388 |
G | HOH2050 |
site_id | BC3 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE FES I 900 |
Chain | Residue |
I | CYS100 |
I | HIS102 |
I | ARG103 |
I | CYS120 |
I | HIS123 |
I | TRP125 |
I | HOH2025 |
site_id | BC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE FE2 I 901 |
Chain | Residue |
I | GLN226 |
I | HIS233 |
I | HIS239 |
I | ASP388 |
I | HOH2068 |
site_id | BC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE FES K 900 |
Chain | Residue |
K | CYS100 |
K | HIS102 |
K | ARG103 |
K | CYS120 |
K | HIS123 |
K | TRP125 |
site_id | BC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE FE2 K 901 |
Chain | Residue |
K | HIS239 |
K | ASP388 |
K | HOH2063 |
K | GLN226 |
K | HIS233 |
Functional Information from PROSITE/UniProt
site_id | PS00570 |
Number of Residues | 24 |
Details | RING_HYDROXYL_ALPHA Bacterial ring hydroxylating dioxygenases alpha-subunit signature. CrHRGmricrsdaGNakaftCsYH |
Chain | Residue | Details |
A | CYS100-HIS123 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 24 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00628 |
Chain | Residue | Details |
A | CYS100 | |
E | HIS102 | |
E | CYS120 | |
E | HIS123 | |
G | CYS100 | |
G | HIS102 | |
G | CYS120 | |
G | HIS123 | |
I | CYS100 | |
I | HIS102 | |
I | CYS120 | |
A | HIS102 | |
I | HIS123 | |
K | CYS100 | |
K | HIS102 | |
K | CYS120 | |
K | HIS123 | |
A | CYS120 | |
A | HIS123 | |
C | CYS100 | |
C | HIS102 | |
C | CYS120 | |
C | HIS123 | |
E | CYS100 |
site_id | SWS_FT_FI2 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0000250 |
Chain | Residue | Details |
A | HIS233 | |
I | HIS239 | |
K | HIS233 | |
K | HIS239 | |
A | HIS239 | |
C | HIS233 | |
C | HIS239 | |
E | HIS233 | |
E | HIS239 | |
G | HIS233 | |
G | HIS239 | |
I | HIS233 |