2XSH

CRYSTAL STRUCTURE OF P4 VARIANT OF BIPHENYL DIOXYGENASE FROM BURKHOLDERIA XENOVORANS LB400 IN COMPLEX WITH 2,6 DI CHLOROBIPHENYL

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005506	molecular_function	iron ion binding
A	0018687	molecular_function	biphenyl 2,3-dioxygenase activity
A	0051537	molecular_function	2 iron, 2 sulfur cluster binding
B	0018687	molecular_function	biphenyl 2,3-dioxygenase activity
B	0019380	biological_process	3-phenylpropionate catabolic process
C	0005506	molecular_function	iron ion binding
C	0018687	molecular_function	biphenyl 2,3-dioxygenase activity
C	0051537	molecular_function	2 iron, 2 sulfur cluster binding
D	0018687	molecular_function	biphenyl 2,3-dioxygenase activity
D	0019380	biological_process	3-phenylpropionate catabolic process
E	0005506	molecular_function	iron ion binding
E	0018687	molecular_function	biphenyl 2,3-dioxygenase activity
E	0051537	molecular_function	2 iron, 2 sulfur cluster binding
F	0018687	molecular_function	biphenyl 2,3-dioxygenase activity
F	0019380	biological_process	3-phenylpropionate catabolic process
G	0005506	molecular_function	iron ion binding
G	0018687	molecular_function	biphenyl 2,3-dioxygenase activity
G	0051537	molecular_function	2 iron, 2 sulfur cluster binding
H	0018687	molecular_function	biphenyl 2,3-dioxygenase activity
H	0019380	biological_process	3-phenylpropionate catabolic process
I	0005506	molecular_function	iron ion binding
I	0018687	molecular_function	biphenyl 2,3-dioxygenase activity
I	0051537	molecular_function	2 iron, 2 sulfur cluster binding
J	0018687	molecular_function	biphenyl 2,3-dioxygenase activity
J	0019380	biological_process	3-phenylpropionate catabolic process
K	0005506	molecular_function	iron ion binding
K	0018687	molecular_function	biphenyl 2,3-dioxygenase activity
K	0051537	molecular_function	2 iron, 2 sulfur cluster binding
L	0018687	molecular_function	biphenyl 2,3-dioxygenase activity
L	0019380	biological_process	3-phenylpropionate catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FES A 900

Chain	Residue
A	CYS100
A	HIS102
A	ARG103
A	CYS120
A	HIS123
A	TRP125

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE2 A 901

Chain	Residue
A	ASP388
A	HOH2109
A	GLN226
A	HIS233
A	HIS239

---

site_id	AC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE DC5 A 902

Chain	Residue
A	GLN226
A	ASP230
A	MET231
A	HIS233
A	HIS239
A	SER283
A	GLN322
A	HIS323
A	LEU333
A	PHE384

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FES C 900

Chain	Residue
C	CYS100
C	HIS102
C	ARG103
C	CYS120
C	HIS123
C	TRP125

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE2 C 901

Chain	Residue
C	GLN226
C	HIS233
C	HIS239
C	ASP388
C	HOH2073

---

site_id	AC6
Number of Residues	11
Details	BINDING SITE FOR RESIDUE DC5 C 902

Chain	Residue
C	GLN226
C	ASP230
C	MET231
C	HIS233
C	ALA234
C	HIS239
C	GLN322
C	HIS323
C	LEU333
C	PHE384
C	HOH2073

---

site_id	AC7
Number of Residues	11
Details	BINDING SITE FOR RESIDUE DC5 E 900

Chain	Residue
E	GLN226
E	ASP230
E	MET231
E	HIS233
E	ALA234
E	HIS239
E	GLN322
E	HIS323
E	LEU333
E	MET336
E	PHE384

---

site_id	AC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE FES E 901

Chain	Residue
E	CYS100
E	HIS102
E	ARG103
E	MET105
E	CYS120
E	HIS123
E	TRP125

---

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE2 E 902

Chain	Residue
E	GLN226
E	HIS233
E	HIS239
E	ASP388
E	HOH2101

---

site_id	BC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE FES G 900

Chain	Residue
G	CYS100
G	HIS102
G	ARG103
G	CYS120
G	HIS123
G	TRP125
G	HOH2019
G	HOH2023

---

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE2 G 901

Chain	Residue
G	GLN226
G	HIS233
G	HIS239
G	ASP388
G	HOH2050

---

site_id	BC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE FES I 900

Chain	Residue
I	CYS100
I	HIS102
I	ARG103
I	CYS120
I	HIS123
I	TRP125
I	HOH2025

---

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE2 I 901

Chain	Residue
I	GLN226
I	HIS233
I	HIS239
I	ASP388
I	HOH2068

---

site_id	BC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FES K 900

Chain	Residue
K	CYS100
K	HIS102
K	ARG103
K	CYS120
K	HIS123
K	TRP125

---

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE2 K 901

Chain	Residue
K	HIS239
K	ASP388
K	HOH2063
K	GLN226
K	HIS233

---

Functional Information from PROSITE/UniProt

site_id	PS00570
Number of Residues	24
Details	RING_HYDROXYL_ALPHA Bacterial ring hydroxylating dioxygenases alpha-subunit signature. CrHRGmricrsdaGNakaftCsYH

Chain	Residue	Details
A	CYS100-HIS123

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00628","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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