2XRF

Crystal structure of human uridine phosphorylase 2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004850	molecular_function	uridine phosphorylase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006218	biological_process	uridine catabolic process
A	0006248	biological_process	CMP catabolic process
A	0006249	biological_process	dCMP catabolic process
A	0009032	molecular_function	thymidine phosphorylase activity
A	0009116	biological_process	nucleoside metabolic process
A	0009166	biological_process	nucleotide catabolic process
A	0016154	molecular_function	pyrimidine-nucleoside phosphorylase activity
A	0016740	molecular_function	transferase activity
A	0016757	molecular_function	glycosyltransferase activity
A	0016763	molecular_function	pentosyltransferase activity
A	0042178	biological_process	xenobiotic catabolic process
A	0042802	molecular_function	identical protein binding
A	0044206	biological_process	UMP salvage
A	0045098	cellular_component	type III intermediate filament
A	0046050	biological_process	UMP catabolic process
A	0046074	biological_process	dTMP catabolic process
A	0046079	biological_process	dUMP catabolic process
A	0046108	biological_process	uridine metabolic process
A	0047847	molecular_function	deoxyuridine phosphorylase activity
B	0003824	molecular_function	catalytic activity
B	0004850	molecular_function	uridine phosphorylase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006218	biological_process	uridine catabolic process
B	0006248	biological_process	CMP catabolic process
B	0006249	biological_process	dCMP catabolic process
B	0009032	molecular_function	thymidine phosphorylase activity
B	0009116	biological_process	nucleoside metabolic process
B	0009166	biological_process	nucleotide catabolic process
B	0016154	molecular_function	pyrimidine-nucleoside phosphorylase activity
B	0016740	molecular_function	transferase activity
B	0016757	molecular_function	glycosyltransferase activity
B	0016763	molecular_function	pentosyltransferase activity
B	0042178	biological_process	xenobiotic catabolic process
B	0042802	molecular_function	identical protein binding
B	0044206	biological_process	UMP salvage
B	0045098	cellular_component	type III intermediate filament
B	0046050	biological_process	UMP catabolic process
B	0046074	biological_process	dTMP catabolic process
B	0046079	biological_process	dUMP catabolic process
B	0046108	biological_process	uridine metabolic process
B	0047847	molecular_function	deoxyuridine phosphorylase activity
C	0003824	molecular_function	catalytic activity
C	0004850	molecular_function	uridine phosphorylase activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006218	biological_process	uridine catabolic process
C	0006248	biological_process	CMP catabolic process
C	0006249	biological_process	dCMP catabolic process
C	0009032	molecular_function	thymidine phosphorylase activity
C	0009116	biological_process	nucleoside metabolic process
C	0009166	biological_process	nucleotide catabolic process
C	0016154	molecular_function	pyrimidine-nucleoside phosphorylase activity
C	0016740	molecular_function	transferase activity
C	0016757	molecular_function	glycosyltransferase activity
C	0016763	molecular_function	pentosyltransferase activity
C	0042178	biological_process	xenobiotic catabolic process
C	0042802	molecular_function	identical protein binding
C	0044206	biological_process	UMP salvage
C	0045098	cellular_component	type III intermediate filament
C	0046050	biological_process	UMP catabolic process
C	0046074	biological_process	dTMP catabolic process
C	0046079	biological_process	dUMP catabolic process
C	0046108	biological_process	uridine metabolic process
C	0047847	molecular_function	deoxyuridine phosphorylase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG C 400

Chain	Residue
C	ASP93
C	CYS95
C	THR98
C	TYR101
C	CYS102
C	HOH2034

---

site_id	AC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE URA C 401

Chain	Residue
C	PHE219
C	GLN223
C	ARG225
C	ILE253
C	GLU254
C	MET255
C	GOL1316
C	HOH2140
C	THR147
C	SER148
C	GLY149

---

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL C 1316

Chain	Residue
B	HIS42
C	MET116
C	PHE219
C	GLU256
C	URA401
C	HOH2121
C	HOH2141

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 400

Chain	Residue
A	ASP93
A	CYS95
A	THR98
A	TYR101
A	CYS102

---

site_id	AC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE URA A 401

Chain	Residue
A	SER148
A	GLY149
A	PHE219
A	GLN223
A	ARG225
A	ILE253
A	GLU254
A	GOL1316
A	HOH2110

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 1316

Chain	Residue
A	HIS42
A	MET116
A	GLU256
A	URA401
A	HOH2059
A	HOH2123

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG B 400

Chain	Residue
B	ASP93
B	CYS95
B	THR98
B	TYR101
B	CYS102
B	HOH2034

---

site_id	AC8
Number of Residues	11
Details	BINDING SITE FOR RESIDUE URA B 401

Chain	Residue
B	SER148
B	GLY149
B	PHE219
B	GLN223
B	ARG225
B	ILE253
B	GLU254
B	MET255
B	LEU279
B	GOL1316
B	HOH2139

---

site_id	AC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL B 1316

Chain	Residue
B	MET116
B	PHE219
B	GLU256
B	URA401
B	HOH2116
B	HOH2140
C	HIS42

---

Functional Information from PROSITE/UniProt

site_id	PS01232
Number of Residues	16
Details	PNP_UDP_1 Purine and other phosphorylases family 1 signature. ShGMGiPSiSImlhEL

Chain	Residue	Details
A	SER113-LEU128

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	15
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21855639","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3P0E","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21855639","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2XRF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3P0E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3P0F","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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