2XPW

TetR(D) in complex with oxytetracycline and magnesium.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0045892	biological_process	negative regulation of DNA-templated transcription
A	0046677	biological_process	response to antibiotic
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	19
Details	BINDING SITE FOR RESIDUE OTC A 222

Chain	Residue
A	HIS64
A	ILE134
A	SER138
A	LEU170
A	MET177
A	MG223
A	HOH2126
A	HOH2166
A	HOH2217
A	HOH2281
A	HOH2282
A	SER67
A	ASN82
A	PHE86
A	HIS100
A	ARG104
A	PRO105
A	VAL113
A	GLN116

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CL A 301

Chain	Residue
A	HIS63
A	ARG92
A	TYR93
A	HOH2043
A	HOH2155
A	HOH2155

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 302

Chain	Residue
A	SER2
A	ARG3
A	SER74
A	SER77

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 303

Chain	Residue
A	LEU4
A	GLN76
A	ARG80
A	HOH2269

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 223

Chain	Residue
A	HIS100
A	OTC222
A	HOH2166
A	HOH2217
A	HOH2282

---

site_id	AC6
Number of Residues	10
Details	BINDING SITE FOR RESIDUE MES A 777

Chain	Residue
A	LEU25
A	THR26
A	THR27
A	ASN47
A	LYS48
A	LEU51
A	HOH2057
A	HOH2093
A	HOH2283
A	HOH2284

---

Functional Information from PROSITE/UniProt

site_id	PS01081
Number of Residues	32
Details	HTH_TETR_1 TetR-type HTH domain signature. GIdglTTrkLaqklgIEqPtLYwHVkNKralL

Chain	Residue	Details
A	GLY21-LEU52

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	19
Details	DNA_BIND: H-T-H motif => ECO:0000255|PROSITE-ProRule:PRU00335

Chain	Residue	Details
A	THR26-VAL45

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:8153629, ECO:0007744|PDB:2TRT

Chain	Residue	Details
A	HIS64
A	ASN82
A	HIS100

---