2XPV

TetR(D) in complex with minocycline and magnesium.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000976	molecular_function	transcription cis-regulatory region binding
A	0003677	molecular_function	DNA binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0006355	biological_process	regulation of DNA-templated transcription
A	0045892	biological_process	negative regulation of DNA-templated transcription
A	0046677	biological_process	response to antibiotic
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	21
Details	BINDING SITE FOR RESIDUE MIY A 1209

Chain	Residue
A	HIS64
A	VAL113
A	GLN116
A	LEU131
A	SER138
A	LEU170
A	ALA173
A	MET177
A	MG1210
A	HOH2163
A	HOH2165
A	SER67
A	HOH2180
A	HOH2272
A	ASN82
A	PHE86
A	HIS100
A	THR103
A	ARG104
A	PRO105
A	THR112

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 1210

Chain	Residue
A	HIS100
A	MIY1209
A	HOH2163
A	HOH2165
A	HOH2272

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 1211

Chain	Residue
A	SER2
A	ARG3
A	SER74
A	SER77

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 1212

Chain	Residue
A	LEU4
A	GLN76
A	ARG80
A	HOH2253

---

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 1213

Chain	Residue
A	THR26
A	THR27

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 1214

Chain	Residue
A	ASN5
A	ARG6
A	GLU7
A	HOH2029

---

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 1215

Chain	Residue
A	SER2
A	ASN81

---

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 1216

Chain	Residue
A	TRP75
A	GLN76

---

site_id	AC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 1217

Chain	Residue
A	ARG195

---

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 1218

Chain	Residue
A	THR26
A	ARG28
A	HOH2030
A	HOH2071

---

Functional Information from PROSITE/UniProt

site_id	PS01081
Number of Residues	32
Details	HTH_TETR_1 TetR-type HTH domain signature. GIdglTTrkLaqklgIEqPtLYwHVkNKralL

Chain	Residue	Details
A	GLY21-LEU52

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	19
Details	DNA_BIND: H-T-H motif => ECO:0000255|PROSITE-ProRule:PRU00335

Chain	Residue	Details
A	THR26-VAL45

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:8153629, ECO:0007744|PDB:2TRT

Chain	Residue	Details
A	HIS64
A	ASN82
A	HIS100

---