2XPH

Crystal structure of human SENP1 with the bound cobalt

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006508	biological_process	proteolysis
A	0008234	molecular_function	cysteine-type peptidase activity
B	0006508	biological_process	proteolysis
B	0008234	molecular_function	cysteine-type peptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL A 1645

Chain	Residue
A	ILE555
B	TRP465

---

site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL A 1646

Chain	Residue
A	LYS543
B	GLN569

---

site_id	AC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE GOL A 1647

Chain	Residue
A	LYS632

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 1648

Chain	Residue
A	GLN440
A	TRP584
A	LEU586
A	HOH2003

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 1649

Chain	Residue
A	PRO421
A	LYS616
A	ASN621
A	PHE630
A	ARG633
A	HOH2041

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL B 1645

Chain	Residue
B	LYS429
B	GLN458
B	ASN461
B	ASN464

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CO B 1646

Chain	Residue
A	GLU430
A	HIS640
B	GLU430
B	HIS640

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	326
Details	Region: {"description":"Protease","evidences":[{"source":"PubMed","id":"16553580","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	18
Details	Motif: {"description":"Nuclear localization signal","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	18
Details	Motif: {"description":"Nuclear export signal","evidences":[{"source":"PubMed","id":"16253240","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Active site: {"evidences":[{"source":"PubMed","id":"16553580","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"16553580","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---