2XOK

Refined structure of yeast F1c10 ATPase complex to 3 A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005524	molecular_function	ATP binding
A	0005739	cellular_component	mitochondrion
A	0005743	cellular_component	mitochondrial inner membrane
A	0005753	cellular_component	mitochondrial proton-transporting ATP synthase complex
A	0005754	cellular_component	mitochondrial proton-transporting ATP synthase, catalytic core
A	0005758	cellular_component	mitochondrial intermembrane space
A	0005829	cellular_component	cytosol
A	0006754	biological_process	ATP biosynthetic process
A	0015986	biological_process	proton motive force-driven ATP synthesis
A	0016020	cellular_component	membrane
A	0016887	molecular_function	ATP hydrolysis activity
A	0032559	molecular_function	adenyl ribonucleotide binding
A	0042645	cellular_component	mitochondrial nucleoid
A	0043531	molecular_function	ADP binding
A	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
A	0046034	biological_process	ATP metabolic process
A	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
A	1902600	biological_process	proton transmembrane transport
B	0005524	molecular_function	ATP binding
B	0005739	cellular_component	mitochondrion
B	0005743	cellular_component	mitochondrial inner membrane
B	0005753	cellular_component	mitochondrial proton-transporting ATP synthase complex
B	0005754	cellular_component	mitochondrial proton-transporting ATP synthase, catalytic core
B	0005758	cellular_component	mitochondrial intermembrane space
B	0005829	cellular_component	cytosol
B	0006754	biological_process	ATP biosynthetic process
B	0015986	biological_process	proton motive force-driven ATP synthesis
B	0016020	cellular_component	membrane
B	0016887	molecular_function	ATP hydrolysis activity
B	0032559	molecular_function	adenyl ribonucleotide binding
B	0042645	cellular_component	mitochondrial nucleoid
B	0043531	molecular_function	ADP binding
B	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
B	0046034	biological_process	ATP metabolic process
B	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
B	1902600	biological_process	proton transmembrane transport
C	0005524	molecular_function	ATP binding
C	0005739	cellular_component	mitochondrion
C	0005743	cellular_component	mitochondrial inner membrane
C	0005753	cellular_component	mitochondrial proton-transporting ATP synthase complex
C	0005754	cellular_component	mitochondrial proton-transporting ATP synthase, catalytic core
C	0005758	cellular_component	mitochondrial intermembrane space
C	0005829	cellular_component	cytosol
C	0006754	biological_process	ATP biosynthetic process
C	0015986	biological_process	proton motive force-driven ATP synthesis
C	0016020	cellular_component	membrane
C	0016887	molecular_function	ATP hydrolysis activity
C	0032559	molecular_function	adenyl ribonucleotide binding
C	0042645	cellular_component	mitochondrial nucleoid
C	0043531	molecular_function	ADP binding
C	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
C	0046034	biological_process	ATP metabolic process
C	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
C	1902600	biological_process	proton transmembrane transport
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005739	cellular_component	mitochondrion
D	0005743	cellular_component	mitochondrial inner membrane
D	0005753	cellular_component	mitochondrial proton-transporting ATP synthase complex
D	0005754	cellular_component	mitochondrial proton-transporting ATP synthase, catalytic core
D	0005758	cellular_component	mitochondrial intermembrane space
D	0005829	cellular_component	cytosol
D	0006754	biological_process	ATP biosynthetic process
D	0015986	biological_process	proton motive force-driven ATP synthesis
D	0016020	cellular_component	membrane
D	0016887	molecular_function	ATP hydrolysis activity
D	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
D	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
D	0046034	biological_process	ATP metabolic process
D	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
D	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
D	1902600	biological_process	proton transmembrane transport
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005739	cellular_component	mitochondrion
E	0005743	cellular_component	mitochondrial inner membrane
E	0005753	cellular_component	mitochondrial proton-transporting ATP synthase complex
E	0005754	cellular_component	mitochondrial proton-transporting ATP synthase, catalytic core
E	0005758	cellular_component	mitochondrial intermembrane space
E	0005829	cellular_component	cytosol
E	0006754	biological_process	ATP biosynthetic process
E	0015986	biological_process	proton motive force-driven ATP synthesis
E	0016020	cellular_component	membrane
E	0016887	molecular_function	ATP hydrolysis activity
E	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
E	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
E	0046034	biological_process	ATP metabolic process
E	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
E	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
E	1902600	biological_process	proton transmembrane transport
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005739	cellular_component	mitochondrion
F	0005743	cellular_component	mitochondrial inner membrane
F	0005753	cellular_component	mitochondrial proton-transporting ATP synthase complex
F	0005754	cellular_component	mitochondrial proton-transporting ATP synthase, catalytic core
F	0005758	cellular_component	mitochondrial intermembrane space
F	0005829	cellular_component	cytosol
F	0006754	biological_process	ATP biosynthetic process
F	0015986	biological_process	proton motive force-driven ATP synthesis
F	0016020	cellular_component	membrane
F	0016887	molecular_function	ATP hydrolysis activity
F	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
F	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
F	0046034	biological_process	ATP metabolic process
F	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
F	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
F	1902600	biological_process	proton transmembrane transport
G	0000275	cellular_component	mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)
G	0005739	cellular_component	mitochondrion
G	0005743	cellular_component	mitochondrial inner membrane
G	0005753	cellular_component	mitochondrial proton-transporting ATP synthase complex
G	0005756	cellular_component	mitochondrial proton-transporting ATP synthase, central stalk
G	0006754	biological_process	ATP biosynthetic process
G	0015986	biological_process	proton motive force-driven ATP synthesis
G	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
G	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
G	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
G	1902600	biological_process	proton transmembrane transport
H	0000275	cellular_component	mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)
H	0005739	cellular_component	mitochondrion
H	0005743	cellular_component	mitochondrial inner membrane
H	0005753	cellular_component	mitochondrial proton-transporting ATP synthase complex
H	0005756	cellular_component	mitochondrial proton-transporting ATP synthase, central stalk
H	0006754	biological_process	ATP biosynthetic process
H	0015986	biological_process	proton motive force-driven ATP synthesis
H	0016887	molecular_function	ATP hydrolysis activity
H	0045261	cellular_component	proton-transporting ATP synthase complex, catalytic core F(1)
H	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
H	1902600	biological_process	proton transmembrane transport
I	0000275	cellular_component	mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)
I	0005739	cellular_component	mitochondrion
I	0005743	cellular_component	mitochondrial inner membrane
I	0015986	biological_process	proton motive force-driven ATP synthesis
I	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
I	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
K	0000276	cellular_component	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
K	0005739	cellular_component	mitochondrion
K	0005743	cellular_component	mitochondrial inner membrane
K	0005753	cellular_component	mitochondrial proton-transporting ATP synthase complex
K	0005758	cellular_component	mitochondrial intermembrane space
K	0005829	cellular_component	cytosol
K	0008289	molecular_function	lipid binding
K	0015078	molecular_function	proton transmembrane transporter activity
K	0015986	biological_process	proton motive force-driven ATP synthesis
K	0016020	cellular_component	membrane
K	0016887	molecular_function	ATP hydrolysis activity
K	0031966	cellular_component	mitochondrial membrane
K	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
K	0042802	molecular_function	identical protein binding
K	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
K	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
K	1902600	biological_process	proton transmembrane transport
L	0000276	cellular_component	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
L	0005739	cellular_component	mitochondrion
L	0005743	cellular_component	mitochondrial inner membrane
L	0005753	cellular_component	mitochondrial proton-transporting ATP synthase complex
L	0005758	cellular_component	mitochondrial intermembrane space
L	0005829	cellular_component	cytosol
L	0008289	molecular_function	lipid binding
L	0015078	molecular_function	proton transmembrane transporter activity
L	0015986	biological_process	proton motive force-driven ATP synthesis
L	0016020	cellular_component	membrane
L	0016887	molecular_function	ATP hydrolysis activity
L	0031966	cellular_component	mitochondrial membrane
L	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
L	0042802	molecular_function	identical protein binding
L	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
L	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
L	1902600	biological_process	proton transmembrane transport
M	0000276	cellular_component	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
M	0005739	cellular_component	mitochondrion
M	0005743	cellular_component	mitochondrial inner membrane
M	0005753	cellular_component	mitochondrial proton-transporting ATP synthase complex
M	0005758	cellular_component	mitochondrial intermembrane space
M	0005829	cellular_component	cytosol
M	0008289	molecular_function	lipid binding
M	0015078	molecular_function	proton transmembrane transporter activity
M	0015986	biological_process	proton motive force-driven ATP synthesis
M	0016020	cellular_component	membrane
M	0016887	molecular_function	ATP hydrolysis activity
M	0031966	cellular_component	mitochondrial membrane
M	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
M	0042802	molecular_function	identical protein binding
M	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
M	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
M	1902600	biological_process	proton transmembrane transport
N	0000276	cellular_component	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
N	0005739	cellular_component	mitochondrion
N	0005743	cellular_component	mitochondrial inner membrane
N	0005753	cellular_component	mitochondrial proton-transporting ATP synthase complex
N	0005758	cellular_component	mitochondrial intermembrane space
N	0005829	cellular_component	cytosol
N	0008289	molecular_function	lipid binding
N	0015078	molecular_function	proton transmembrane transporter activity
N	0015986	biological_process	proton motive force-driven ATP synthesis
N	0016020	cellular_component	membrane
N	0016887	molecular_function	ATP hydrolysis activity
N	0031966	cellular_component	mitochondrial membrane
N	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
N	0042802	molecular_function	identical protein binding
N	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
N	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
N	1902600	biological_process	proton transmembrane transport
O	0000276	cellular_component	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
O	0005739	cellular_component	mitochondrion
O	0005743	cellular_component	mitochondrial inner membrane
O	0005753	cellular_component	mitochondrial proton-transporting ATP synthase complex
O	0005758	cellular_component	mitochondrial intermembrane space
O	0005829	cellular_component	cytosol
O	0008289	molecular_function	lipid binding
O	0015078	molecular_function	proton transmembrane transporter activity
O	0015986	biological_process	proton motive force-driven ATP synthesis
O	0016020	cellular_component	membrane
O	0016887	molecular_function	ATP hydrolysis activity
O	0031966	cellular_component	mitochondrial membrane
O	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
O	0042802	molecular_function	identical protein binding
O	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
O	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
O	1902600	biological_process	proton transmembrane transport
P	0000276	cellular_component	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
P	0005739	cellular_component	mitochondrion
P	0005743	cellular_component	mitochondrial inner membrane
P	0005753	cellular_component	mitochondrial proton-transporting ATP synthase complex
P	0005758	cellular_component	mitochondrial intermembrane space
P	0005829	cellular_component	cytosol
P	0008289	molecular_function	lipid binding
P	0015078	molecular_function	proton transmembrane transporter activity
P	0015986	biological_process	proton motive force-driven ATP synthesis
P	0016020	cellular_component	membrane
P	0016887	molecular_function	ATP hydrolysis activity
P	0031966	cellular_component	mitochondrial membrane
P	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
P	0042802	molecular_function	identical protein binding
P	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
P	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
P	1902600	biological_process	proton transmembrane transport
Q	0000276	cellular_component	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
Q	0005739	cellular_component	mitochondrion
Q	0005743	cellular_component	mitochondrial inner membrane
Q	0005753	cellular_component	mitochondrial proton-transporting ATP synthase complex
Q	0005758	cellular_component	mitochondrial intermembrane space
Q	0005829	cellular_component	cytosol
Q	0008289	molecular_function	lipid binding
Q	0015078	molecular_function	proton transmembrane transporter activity
Q	0015986	biological_process	proton motive force-driven ATP synthesis
Q	0016020	cellular_component	membrane
Q	0016887	molecular_function	ATP hydrolysis activity
Q	0031966	cellular_component	mitochondrial membrane
Q	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
Q	0042802	molecular_function	identical protein binding
Q	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
Q	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
Q	1902600	biological_process	proton transmembrane transport
R	0000276	cellular_component	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
R	0005739	cellular_component	mitochondrion
R	0005743	cellular_component	mitochondrial inner membrane
R	0005753	cellular_component	mitochondrial proton-transporting ATP synthase complex
R	0005758	cellular_component	mitochondrial intermembrane space
R	0005829	cellular_component	cytosol
R	0008289	molecular_function	lipid binding
R	0015078	molecular_function	proton transmembrane transporter activity
R	0015986	biological_process	proton motive force-driven ATP synthesis
R	0016020	cellular_component	membrane
R	0016887	molecular_function	ATP hydrolysis activity
R	0031966	cellular_component	mitochondrial membrane
R	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
R	0042802	molecular_function	identical protein binding
R	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
R	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
R	1902600	biological_process	proton transmembrane transport
S	0000276	cellular_component	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
S	0005739	cellular_component	mitochondrion
S	0005743	cellular_component	mitochondrial inner membrane
S	0005753	cellular_component	mitochondrial proton-transporting ATP synthase complex
S	0005758	cellular_component	mitochondrial intermembrane space
S	0005829	cellular_component	cytosol
S	0008289	molecular_function	lipid binding
S	0015078	molecular_function	proton transmembrane transporter activity
S	0015986	biological_process	proton motive force-driven ATP synthesis
S	0016020	cellular_component	membrane
S	0016887	molecular_function	ATP hydrolysis activity
S	0031966	cellular_component	mitochondrial membrane
S	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
S	0042802	molecular_function	identical protein binding
S	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
S	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
S	1902600	biological_process	proton transmembrane transport
T	0000276	cellular_component	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
T	0005739	cellular_component	mitochondrion
T	0005743	cellular_component	mitochondrial inner membrane
T	0005753	cellular_component	mitochondrial proton-transporting ATP synthase complex
T	0005758	cellular_component	mitochondrial intermembrane space
T	0005829	cellular_component	cytosol
T	0008289	molecular_function	lipid binding
T	0015078	molecular_function	proton transmembrane transporter activity
T	0015986	biological_process	proton motive force-driven ATP synthesis
T	0016020	cellular_component	membrane
T	0016887	molecular_function	ATP hydrolysis activity
T	0031966	cellular_component	mitochondrial membrane
T	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
T	0042802	molecular_function	identical protein binding
T	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
T	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
T	1902600	biological_process	proton transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE ANP A 600

Chain	Residue
A	GLN174
A	MG700
A	GLY176
A	LYS177
A	THR178
A	ALA179
A	PHE359
A	ARG364
A	GLN432
A	GLN434

---

site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG A 700

Chain	Residue
A	THR178
A	ANP600

---

site_id	AC3
Number of Residues	13
Details	BINDING SITE FOR RESIDUE ANP B 600

Chain	Residue
B	ARG173
B	GLN174
B	THR175
B	GLY176
B	LYS177
B	THR178
B	ALA179
B	GLU330
B	PHE359
B	ARG364
B	GLN432
B	GLN434
B	MG700

---

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG B 700

Chain	Residue
B	THR178
B	ANP600

---

site_id	AC5
Number of Residues	12
Details	BINDING SITE FOR RESIDUE ANP C 600

Chain	Residue
C	ARG173
C	GLN174
C	THR175
C	GLY176
C	LYS177
C	THR178
C	ALA179
C	GLU330
C	GLN432
C	GLN434
C	MG700
F	TYR368

---

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG C 700

Chain	Residue
C	THR178
C	ANP600

---

site_id	AC7
Number of Residues	17
Details	BINDING SITE FOR RESIDUE ANP D 600

Chain	Residue
C	SER346
C	ARG375
D	GLY158
D	ALA159
D	GLY160
D	VAL161
D	GLY162
D	LYS163
D	THR164
D	VAL165
D	GLU189
D	ARG190
D	TYR345
D	PHE418
D	ALA421
D	PHE424
D	MG700

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG D 700

Chain	Residue
D	THR164
D	GLU189
D	ARG190
D	GLU193
D	ANP600

---

site_id	AC9
Number of Residues	19
Details	BINDING SITE FOR RESIDUE ANP F 600

Chain	Residue
B	ILE345
B	SER346
B	VAL373
B	ARG375
F	GLY158
F	ALA159
F	GLY160
F	VAL161
F	GLY162
F	LYS163
F	THR164
F	VAL165
F	GLU189
F	ARG190
F	TYR345
F	PHE418
F	ALA421
F	PHE424
F	MG700

---

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG F 700

Chain	Residue
F	THR164
F	GLU189
F	GLU193
F	ANP600

---

Functional Information from PROSITE/UniProt

site_id	PS00152
Number of Residues	10
Details	ATPASE_ALPHA_BETA ATP synthase alpha and beta subunits signature. PAVDPLDSKS

Chain	Residue	Details
D	PRO346-SER355
A	PRO365-SER374

---

site_id	PS00153
Number of Residues	14
Details	ATPASE_GAMMA ATP synthase gamma subunit signature. ITnElvDiitGAsS

Chain	Residue	Details
G	ILE263-SER276

---

site_id	PS00605
Number of Residues	22
Details	ATPASE_C ATP synthase c subunit signature. SRNPsikdtVfPmaILgfaLsE

Chain	Residue	Details
K	SER38-GLU59

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	400
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
K	ILE14-ILE34
O	ILE52-LEU72
P	ILE14-ILE34
P	ILE52-LEU72
Q	ILE14-ILE34
Q	ILE52-LEU72
R	ILE14-ILE34
R	ILE52-LEU72
S	ILE14-ILE34
S	ILE52-LEU72
T	ILE14-ILE34
K	ILE52-LEU72
T	ILE52-LEU72
L	ILE14-ILE34
L	ILE52-LEU72
M	ILE14-ILE34
M	ILE52-LEU72
N	ILE14-ILE34
N	ILE52-LEU72
O	ILE14-ILE34

---

site_id	SWS_FT_FI2
Number of Residues	10
Details	SITE: Reversibly protonated during proton transport => ECO:0000250

Chain	Residue	Details
K	GLU59
T	GLU59
L	GLU59
M	GLU59
N	GLU59
O	GLU59
P	GLU59
Q	GLU59
R	GLU59
S	GLU59

---

site_id	SWS_FT_FI3
Number of Residues	10
Details	MOD_RES: N-formylmethionine => ECO:0000269|PubMed:2894987

Chain	Residue	Details
K	MET1
T	MET1
L	MET1
M	MET1
N	MET1
O	MET1
P	MET1
Q	MET1
R	MET1
S	MET1

---