2XO5
RIBONUCLEOTIDE REDUCTASE Y731NH2Y MODIFIED R1 SUBUNIT OF E. COLI
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004748 | molecular_function | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor |
A | 0005515 | molecular_function | protein binding |
A | 0005524 | molecular_function | ATP binding |
A | 0005829 | cellular_component | cytosol |
A | 0005971 | cellular_component | ribonucleoside-diphosphate reductase complex |
A | 0006457 | biological_process | protein folding |
A | 0009185 | biological_process | ribonucleoside diphosphate metabolic process |
A | 0009263 | biological_process | deoxyribonucleotide biosynthetic process |
A | 0009265 | biological_process | 2'-deoxyribonucleotide biosynthetic process |
A | 0015949 | biological_process | nucleobase-containing small molecule interconversion |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0042802 | molecular_function | identical protein binding |
A | 0044183 | molecular_function | protein folding chaperone |
B | 0004748 | molecular_function | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor |
B | 0005515 | molecular_function | protein binding |
B | 0005524 | molecular_function | ATP binding |
B | 0005829 | cellular_component | cytosol |
B | 0005971 | cellular_component | ribonucleoside-diphosphate reductase complex |
B | 0006457 | biological_process | protein folding |
B | 0009185 | biological_process | ribonucleoside diphosphate metabolic process |
B | 0009263 | biological_process | deoxyribonucleotide biosynthetic process |
B | 0009265 | biological_process | 2'-deoxyribonucleotide biosynthetic process |
B | 0015949 | biological_process | nucleobase-containing small molecule interconversion |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0042802 | molecular_function | identical protein binding |
B | 0044183 | molecular_function | protein folding chaperone |
C | 0004748 | molecular_function | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor |
C | 0005515 | molecular_function | protein binding |
C | 0005524 | molecular_function | ATP binding |
C | 0005829 | cellular_component | cytosol |
C | 0005971 | cellular_component | ribonucleoside-diphosphate reductase complex |
C | 0006457 | biological_process | protein folding |
C | 0009185 | biological_process | ribonucleoside diphosphate metabolic process |
C | 0009263 | biological_process | deoxyribonucleotide biosynthetic process |
C | 0009265 | biological_process | 2'-deoxyribonucleotide biosynthetic process |
C | 0015949 | biological_process | nucleobase-containing small molecule interconversion |
C | 0016491 | molecular_function | oxidoreductase activity |
C | 0042802 | molecular_function | identical protein binding |
C | 0044183 | molecular_function | protein folding chaperone |
Functional Information from PROSITE/UniProt
site_id | PS00089 |
Number of Residues | 23 |
Details | RIBORED_LARGE Ribonucleotide reductase large subunit signature. WeaLresikthGLRNstlSAlmP |
Chain | Residue | Details |
A | TRP599-PRO621 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 6 |
Details | ACT_SITE: Proton acceptor |
Chain | Residue | Details |
A | ASN437 | |
A | GLU441 | |
B | ASN437 | |
B | GLU441 | |
C | ASN437 | |
C | GLU441 |
site_id | SWS_FT_FI2 |
Number of Residues | 3 |
Details | ACT_SITE: Cysteine radical intermediate |
Chain | Residue | Details |
A | CYS439 | |
B | CYS439 | |
C | CYS439 |
site_id | SWS_FT_FI3 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0000269|PubMed:9309223, ECO:0007744|PDB:3R1R |
Chain | Residue | Details |
A | LYS9 | |
C | GLU15 | |
C | THR55 | |
C | LYS91 | |
A | GLU15 | |
A | THR55 | |
A | LYS91 | |
B | LYS9 | |
B | GLU15 | |
B | THR55 | |
B | LYS91 | |
C | LYS9 |
site_id | SWS_FT_FI4 |
Number of Residues | 21 |
Details | BINDING: BINDING => ECO:0000269|PubMed:9309223, ECO:0007744|PDB:4R1R |
Chain | Residue | Details |
A | THR209 | |
B | ARG262 | |
B | ARG269 | |
B | ASN437 | |
B | GLU441 | |
B | GLU623 | |
C | THR209 | |
C | ASP232 | |
C | ARG262 | |
C | ARG269 | |
C | ASN437 | |
A | ASP232 | |
C | GLU441 | |
C | GLU623 | |
A | ARG262 | |
A | ARG269 | |
A | ASN437 | |
A | GLU441 | |
A | GLU623 | |
B | THR209 | |
B | ASP232 |
site_id | SWS_FT_FI5 |
Number of Residues | 6 |
Details | SITE: Important for hydrogen atom transfer |
Chain | Residue | Details |
A | CYS225 | |
A | CYS462 | |
B | CYS225 | |
B | CYS462 | |
C | CYS225 | |
C | CYS462 |
site_id | SWS_FT_FI6 |
Number of Residues | 6 |
Details | SITE: Important for electron transfer |
Chain | Residue | Details |
A | TYR730 | |
A | TY2731 | |
B | TYR730 | |
B | TY2731 | |
C | TYR730 | |
C | TY2731 |
site_id | SWS_FT_FI7 |
Number of Residues | 6 |
Details | SITE: Interacts with thioredoxin/glutaredoxin |
Chain | Residue | Details |
A | CYS754 | |
A | CYS759 | |
B | CYS754 | |
B | CYS759 | |
C | CYS754 | |
C | CYS759 |
site_id | SWS_FT_FI8 |
Number of Residues | 3 |
Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:18723842 |
Chain | Residue | Details |
A | LYS283 | |
B | LYS283 | |
C | LYS283 |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | |
Details | M-CSA 918 |
Chain | Residue | Details |
A | CYS225 | proton donor |
A | ASN437 | |
A | CYS439 | hydrogen radical acceptor, hydrogen radical donor, single electron acceptor |
A | GLU441 | proton acceptor |
A | CYS462 | |
A | TYR730 | pi-pi interaction, single electron relay |
A | TY2731 | pi-pi interaction, single electron relay |
site_id | MCSA2 |
Number of Residues | |
Details | M-CSA 918 |
Chain | Residue | Details |
B | CYS225 | proton donor |
B | ASN437 | |
B | CYS439 | hydrogen radical acceptor, hydrogen radical donor, single electron acceptor |
B | GLU441 | proton acceptor |
B | CYS462 | |
B | TYR730 | pi-pi interaction, single electron relay |
B | TY2731 | pi-pi interaction, single electron relay |
site_id | MCSA3 |
Number of Residues | |
Details | M-CSA 918 |
Chain | Residue | Details |
C | CYS225 | proton donor |
C | ASN437 | |
C | CYS439 | hydrogen radical acceptor, hydrogen radical donor, single electron acceptor |
C | GLU441 | proton acceptor |
C | CYS462 | |
C | TYR730 | pi-pi interaction, single electron relay |
C | TY2731 | pi-pi interaction, single electron relay |
site_id | MCSA4 |
Number of Residues | |
Details | M-CSA 918 |
Chain | Residue | Details |