2XO2

Human Annexin V with incorporated Methionine analogue Azidohomoalanine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001786	molecular_function	phosphatidylserine binding
A	0004859	molecular_function	phospholipase inhibitor activity
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005543	molecular_function	phospholipid binding
A	0005544	molecular_function	calcium-dependent phospholipid binding
A	0005576	cellular_component	extracellular region
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005925	cellular_component	focal adhesion
A	0007165	biological_process	signal transduction
A	0007596	biological_process	blood coagulation
A	0007599	biological_process	hemostasis
A	0009897	cellular_component	external side of plasma membrane
A	0012506	cellular_component	vesicle membrane
A	0016020	cellular_component	membrane
A	0031012	cellular_component	extracellular matrix
A	0042383	cellular_component	sarcolemma
A	0043066	biological_process	negative regulation of apoptotic process
A	0050819	biological_process	negative regulation of coagulation
A	0070062	cellular_component	extracellular exosome
A	0072563	cellular_component	endothelial microparticle

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 1327

Chain	Residue
A	GLY183
A	GLU184
A	LYS186
A	GLY188
A	GLU228
A	SO41330

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 1328

Chain	Residue
A	GLY32
A	GLU72
A	AZH28
A	LYS29
A	GLY30

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A 1329

Chain	Residue
A	ASN47
A	ALA83
A	LEU84
A	LYS86
A	VAL274
A	HOH2100

---

site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 1332

Chain	Residue
A	LYS97

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 1330

Chain	Residue
A	LYS186
A	TRP187
A	GLY188
A	GLU228
A	CA1327

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 1331

Chain	Residue
A	ARG25
A	GLY30
A	ARG63

---

Functional Information from PROSITE/UniProt

site_id	PS00223
Number of Residues	53
Details	ANNEXIN_1 Annexin repeat signature. GTdeesiltlLtsRsnaQrqEisaaFktlfgrdLlddLkseltGkfeklIvaL

Chain	Residue	Details
A	GLY32-LEU84
A	GLY104-LEU156
A	GLY188-VAL240

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P48036","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"16916647","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P48036","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"25772364","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---