2XO2
Human Annexin V with incorporated Methionine analogue Azidohomoalanine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001786 | molecular_function | phosphatidylserine binding |
| A | 0004859 | molecular_function | phospholipase inhibitor activity |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005543 | molecular_function | phospholipid binding |
| A | 0005544 | molecular_function | calcium-dependent phospholipid binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005925 | cellular_component | focal adhesion |
| A | 0007165 | biological_process | signal transduction |
| A | 0007596 | biological_process | blood coagulation |
| A | 0007599 | biological_process | hemostasis |
| A | 0009897 | cellular_component | external side of plasma membrane |
| A | 0010033 | biological_process | response to organic substance |
| A | 0016020 | cellular_component | membrane |
| A | 0042383 | cellular_component | sarcolemma |
| A | 0043066 | biological_process | negative regulation of apoptotic process |
| A | 0050819 | biological_process | negative regulation of coagulation |
| A | 0062023 | cellular_component | collagen-containing extracellular matrix |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0072563 | cellular_component | endothelial microparticle |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 1327 |
| Chain | Residue |
| A | GLY183 |
| A | GLU184 |
| A | LYS186 |
| A | GLY188 |
| A | GLU228 |
| A | SO41330 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA A 1328 |
| Chain | Residue |
| A | GLY32 |
| A | GLU72 |
| A | AZH28 |
| A | LYS29 |
| A | GLY30 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA A 1329 |
| Chain | Residue |
| A | ASN47 |
| A | ALA83 |
| A | LEU84 |
| A | LYS86 |
| A | VAL274 |
| A | HOH2100 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL A 1332 |
| Chain | Residue |
| A | LYS97 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1330 |
| Chain | Residue |
| A | LYS186 |
| A | TRP187 |
| A | GLY188 |
| A | GLU228 |
| A | CA1327 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1331 |
| Chain | Residue |
| A | ARG25 |
| A | GLY30 |
| A | ARG63 |
Functional Information from PROSITE/UniProt
| site_id | PS00223 |
| Number of Residues | 53 |
| Details | ANNEXIN_1 Annexin repeat signature. GTdeesiltlLtsRsnaQrqEisaaFktlfgrdLlddLkseltGkfeklIvaL |
| Chain | Residue | Details |
| A | GLY32-LEU84 | |
| A | GLY104-LEU156 | |
| A | GLY188-VAL240 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylalanine => ECO:0007744|PubMed:19413330 |
| Chain | Residue | Details |
| A | ALA2 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P48036 |
| Chain | Residue | Details |
| A | SER37 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | LYS70 | |
| A | LYS76 | |
| A | LYS79 | |
| A | LYS97 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:16916647 |
| Chain | Residue | Details |
| A | LYS101 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P48036 |
| Chain | Residue | Details |
| A | LYS290 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25772364, ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| A | LYS29 |
