2XLT
Joint-functions of protein residues and NADP(H) in oxygen-activation by flavin-containing monooxygenase: complex with 3-Acetylpyridine adenine dinucleotide phosphate (APADP)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004497 | molecular_function | monooxygenase activity |
| A | 0004499 | molecular_function | N,N-dimethylaniline monooxygenase activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| A | 0050661 | molecular_function | NADP binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004497 | molecular_function | monooxygenase activity |
| B | 0004499 | molecular_function | N,N-dimethylaniline monooxygenase activity |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| B | 0050661 | molecular_function | NADP binding |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0004497 | molecular_function | monooxygenase activity |
| C | 0004499 | molecular_function | N,N-dimethylaniline monooxygenase activity |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| C | 0050661 | molecular_function | NADP binding |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0004497 | molecular_function | monooxygenase activity |
| D | 0004499 | molecular_function | N,N-dimethylaniline monooxygenase activity |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| D | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 32 |
| Details | BINDING SITE FOR RESIDUE FAD A 500 |
| Chain | Residue |
| A | GLY14 |
| A | TRP52 |
| A | HIS68 |
| A | MET71 |
| A | SER77 |
| A | ASN78 |
| A | LEU84 |
| A | THR129 |
| A | ALA130 |
| A | VAL131 |
| A | CYS166 |
| A | GLY16 |
| A | THR167 |
| A | PHE170 |
| A | GLN323 |
| A | SER326 |
| A | PHE327 |
| A | NA0501 |
| A | HOH2026 |
| A | HOH2058 |
| A | HOH2206 |
| A | HOH2209 |
| A | PRO17 |
| A | HOH2279 |
| A | HOH2280 |
| A | HOH2281 |
| A | SER18 |
| A | GLU43 |
| A | LYS44 |
| A | GLN45 |
| A | GLY50 |
| A | GLN51 |
| site_id | AC2 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE NA0 A 501 |
| Chain | Residue |
| A | ASN78 |
| A | PHE170 |
| A | TYR174 |
| A | VAL208 |
| A | SER210 |
| A | SER211 |
| A | TYR212 |
| A | SER213 |
| A | ARG234 |
| A | THR235 |
| A | ASN251 |
| A | CYS276 |
| A | THR277 |
| A | GLY278 |
| A | ASP322 |
| A | GLN323 |
| A | TRP324 |
| A | TRP405 |
| A | FAD500 |
| A | HOH2160 |
| A | HOH2208 |
| A | HOH2282 |
| A | HOH2283 |
| site_id | AC3 |
| Number of Residues | 34 |
| Details | BINDING SITE FOR RESIDUE FAD B 500 |
| Chain | Residue |
| B | GLY14 |
| B | GLY16 |
| B | PRO17 |
| B | SER18 |
| B | GLU43 |
| B | LYS44 |
| B | GLN45 |
| B | GLY50 |
| B | GLN51 |
| B | TRP52 |
| B | HIS68 |
| B | MET71 |
| B | LEU75 |
| B | SER77 |
| B | ASN78 |
| B | LEU84 |
| B | THR129 |
| B | VAL131 |
| B | CYS166 |
| B | THR167 |
| B | GLY168 |
| B | PHE170 |
| B | GLN323 |
| B | SER326 |
| B | PHE327 |
| B | PHE330 |
| B | NA0501 |
| B | HOH2020 |
| B | HOH2200 |
| B | HOH2201 |
| B | HOH2282 |
| B | HOH2283 |
| B | HOH2284 |
| B | HOH2285 |
| site_id | AC4 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR RESIDUE NA0 B 501 |
| Chain | Residue |
| B | THR235 |
| B | ASN251 |
| B | CYS276 |
| B | THR277 |
| B | GLY278 |
| B | ASP322 |
| B | GLN323 |
| B | TRP324 |
| B | TRP405 |
| B | FAD500 |
| B | HOH2128 |
| B | HOH2286 |
| B | HOH2287 |
| B | HOH2288 |
| B | HOH2289 |
| B | HOH2290 |
| B | ASN78 |
| B | TYR174 |
| B | PRO176 |
| B | PHE178 |
| B | VAL208 |
| B | SER210 |
| B | SER211 |
| B | TYR212 |
| B | SER213 |
| B | ARG234 |
| site_id | AC5 |
| Number of Residues | 34 |
| Details | BINDING SITE FOR RESIDUE FAD C 500 |
| Chain | Residue |
| C | GLY14 |
| C | GLY16 |
| C | PRO17 |
| C | SER18 |
| C | GLU43 |
| C | LYS44 |
| C | GLN45 |
| C | GLY50 |
| C | GLN51 |
| C | TRP52 |
| C | HIS68 |
| C | MET71 |
| C | SER77 |
| C | ASN78 |
| C | LEU84 |
| C | THR129 |
| C | ALA130 |
| C | VAL131 |
| C | CYS166 |
| C | THR167 |
| C | GLY168 |
| C | PHE170 |
| C | GLN323 |
| C | SER326 |
| C | PHE327 |
| C | NA0501 |
| C | HOH2015 |
| C | HOH2049 |
| C | HOH2254 |
| C | HOH2255 |
| C | HOH2256 |
| C | HOH2257 |
| C | HOH2258 |
| C | HOH2259 |
| site_id | AC6 |
| Number of Residues | 29 |
| Details | BINDING SITE FOR RESIDUE NA0 C 501 |
| Chain | Residue |
| C | ASN78 |
| C | PHE170 |
| C | TYR174 |
| C | PRO176 |
| C | PHE178 |
| C | VAL208 |
| C | SER210 |
| C | SER211 |
| C | TYR212 |
| C | SER213 |
| C | ARG234 |
| C | THR235 |
| C | ASN251 |
| C | CYS276 |
| C | THR277 |
| C | GLY278 |
| C | ASN296 |
| C | ASP322 |
| C | GLN323 |
| C | TRP324 |
| C | PHE402 |
| C | TRP405 |
| C | FAD500 |
| C | HOH2114 |
| C | HOH2133 |
| C | HOH2141 |
| C | HOH2153 |
| C | HOH2260 |
| C | HOH2261 |
| site_id | AC7 |
| Number of Residues | 33 |
| Details | BINDING SITE FOR RESIDUE FAD D 500 |
| Chain | Residue |
| D | GLY14 |
| D | GLY16 |
| D | PRO17 |
| D | SER18 |
| D | GLU43 |
| D | LYS44 |
| D | GLN45 |
| D | GLY50 |
| D | GLN51 |
| D | TRP52 |
| D | HIS68 |
| D | MET71 |
| D | SER77 |
| D | ASN78 |
| D | LEU84 |
| D | THR129 |
| D | ALA130 |
| D | VAL131 |
| D | CYS166 |
| D | THR167 |
| D | PHE170 |
| D | GLN323 |
| D | SER326 |
| D | PHE327 |
| D | NA0501 |
| D | HOH2022 |
| D | HOH2109 |
| D | HOH2183 |
| D | HOH2185 |
| D | HOH2249 |
| D | HOH2250 |
| D | HOH2251 |
| D | HOH2252 |
| site_id | AC8 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE NA0 D 501 |
| Chain | Residue |
| D | ASN78 |
| D | PHE170 |
| D | TYR174 |
| D | PRO176 |
| D | PHE178 |
| D | VAL208 |
| D | SER210 |
| D | SER211 |
| D | TYR212 |
| D | SER213 |
| D | ARG234 |
| D | THR235 |
| D | ASN251 |
| D | CYS276 |
| D | THR277 |
| D | GLY278 |
| D | ASP322 |
| D | GLN323 |
| D | TRP324 |
| D | TRP405 |
| D | FAD500 |
| D | HOH2144 |
| D | HOH2153 |
| D | HOH2253 |
| D | HOH2254 |
| site_id | AC9 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE EPE D 1453 |
| Chain | Residue |
| B | THR294 |
| B | ASN295 |
| D | ARG24 |
| D | GLN27 |
| D | GLU31 |
| D | LYS118 |
| D | ALA119 |
| D | HOH2076 |
| D | HOH2255 |
| site_id | BC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PEG D 1454 |
| Chain | Residue |
| D | TRP360 |
| D | LYS363 |
| D | ASP379 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PEG C 1453 |
| Chain | Residue |
| C | ARG24 |
| C | GLN27 |
| C | GLU31 |
| C | ALA119 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PEG A 1453 |
| Chain | Residue |
| A | GLY185 |
| A | GLY186 |
| A | GLU258 |
| A | LYS269 |
| A | VAL270 |
| site_id | BC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PEG C 1454 |
| Chain | Residue |
| C | GLY185 |
| C | GLY186 |
| C | THR257 |
| C | GLU258 |
| C | LYS269 |
| C | VAL270 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PEG D 1455 |
| Chain | Residue |
| D | GLY185 |
| D | GLY186 |
| D | GLU258 |
| D | LYS269 |
| D | VAL270 |
| site_id | BC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PEG C 1455 |
| Chain | Residue |
| C | ASP256 |
| C | GLU258 |
| C | ASN259 |
| site_id | BC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PEG A 1454 |
| Chain | Residue |
| A | ASP256 |
| A | GLU258 |
| A | ASN259 |
| site_id | BC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PEG B 1453 |
| Chain | Residue |
| B | TRP360 |
| B | ASP379 |
| site_id | BC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PEG B 1454 |
| Chain | Residue |
| B | GLY186 |
| B | GLU258 |
| B | LYS269 |
| B | VAL270 |
| C | LEU198 |
| site_id | CC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE PEG A 1455 |
| Chain | Residue |
| A | TYR222 |
| site_id | CC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PEG D 1456 |
| Chain | Residue |
| D | ASP256 |
| D | GLU258 |
| D | ASN259 |
| site_id | CC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PEG B 1455 |
| Chain | Residue |
| B | GLU258 |
| B | ASN259 |
| B | LYS269 |
| site_id | CC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PEG A 1456 |
| Chain | Residue |
| A | ALA359 |
| A | LYS363 |
| site_id | CC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE PEG B 1456 |
| Chain | Residue |
| B | ARG234 |
| site_id | CC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PEG D 1457 |
| Chain | Residue |
| B | GLU93 |
| D | ARG234 |
| site_id | CC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EPE B 1457 |
| Chain | Residue |
| B | ARG24 |
| B | GLN27 |
| B | GLU31 |
| B | LYS118 |
| B | ALA119 |
| B | HOH2292 |
| B | HOH2293 |
| D | ASN295 |
| site_id | CC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EPE A 1457 |
| Chain | Residue |
| A | ARG24 |
| A | GLN27 |
| A | GLU31 |
| A | LYS118 |
| A | ALA119 |
| A | HOH2285 |
| C | ASN295 |
