2XLS
Joint-functions of protein residues and NADP(H) in oxygen-activation by flavin-containing monooxygenase: Asn78Lys mutant
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004497 | molecular_function | monooxygenase activity |
| A | 0004499 | molecular_function | N,N-dimethylaniline monooxygenase activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| A | 0050661 | molecular_function | NADP binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004497 | molecular_function | monooxygenase activity |
| B | 0004499 | molecular_function | N,N-dimethylaniline monooxygenase activity |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| B | 0050661 | molecular_function | NADP binding |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0004497 | molecular_function | monooxygenase activity |
| C | 0004499 | molecular_function | N,N-dimethylaniline monooxygenase activity |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| C | 0050661 | molecular_function | NADP binding |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0004497 | molecular_function | monooxygenase activity |
| D | 0004499 | molecular_function | N,N-dimethylaniline monooxygenase activity |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| D | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE FAD A 500 |
| Chain | Residue |
| A | GLY14 |
| A | TRP52 |
| A | HIS68 |
| A | SER70 |
| A | MET71 |
| A | SER77 |
| A | LYS78 |
| A | THR129 |
| A | ALA130 |
| A | VAL131 |
| A | CYS166 |
| A | GLY16 |
| A | THR167 |
| A | GLY168 |
| A | PHE170 |
| A | GLN323 |
| A | SER326 |
| A | PHE327 |
| A | PHE330 |
| A | HOH2003 |
| A | PRO17 |
| A | SER18 |
| A | GLU43 |
| A | LYS44 |
| A | GLN45 |
| A | GLY50 |
| A | GLN51 |
| site_id | AC2 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE NAP A 501 |
| Chain | Residue |
| A | LYS78 |
| A | PRO176 |
| A | VAL208 |
| A | SER210 |
| A | SER211 |
| A | TYR212 |
| A | SER213 |
| A | ARG234 |
| A | THR235 |
| A | ASN251 |
| A | CYS276 |
| A | THR277 |
| A | GLY278 |
| A | ASN296 |
| A | ASP322 |
| A | GLN323 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EPE A 1451 |
| Chain | Residue |
| A | ARG24 |
| A | GLN27 |
| A | GLU31 |
| A | LYS118 |
| A | ALA119 |
| C | ASN295 |
| site_id | AC4 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE FAD B 500 |
| Chain | Residue |
| B | GLY14 |
| B | GLY16 |
| B | PRO17 |
| B | SER18 |
| B | GLU43 |
| B | LYS44 |
| B | GLN45 |
| B | GLY50 |
| B | GLN51 |
| B | TRP52 |
| B | HIS68 |
| B | SER70 |
| B | MET71 |
| B | SER77 |
| B | LYS78 |
| B | THR129 |
| B | ALA130 |
| B | VAL131 |
| B | CYS166 |
| B | THR167 |
| B | PHE170 |
| B | PHE285 |
| B | GLN323 |
| B | SER326 |
| B | PHE327 |
| B | PHE330 |
| B | HOH2007 |
| site_id | AC5 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE NAP B 501 |
| Chain | Residue |
| B | LYS78 |
| B | PHE170 |
| B | TYR174 |
| B | PRO176 |
| B | VAL208 |
| B | SER210 |
| B | SER211 |
| B | TYR212 |
| B | SER213 |
| B | ARG234 |
| B | THR235 |
| B | ASN251 |
| B | CYS276 |
| B | THR277 |
| B | GLY278 |
| B | ASN296 |
| B | ASP322 |
| B | GLN323 |
| B | HOH2004 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EPE B 1453 |
| Chain | Residue |
| B | ALA119 |
| B | ARG24 |
| B | GLN27 |
| B | GLU31 |
| B | LYS118 |
| site_id | AC7 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE FAD C 500 |
| Chain | Residue |
| C | GLY14 |
| C | GLY16 |
| C | PRO17 |
| C | SER18 |
| C | GLU43 |
| C | LYS44 |
| C | GLN45 |
| C | GLY50 |
| C | GLN51 |
| C | TRP52 |
| C | HIS68 |
| C | SER70 |
| C | MET71 |
| C | SER77 |
| C | LYS78 |
| C | THR129 |
| C | ALA130 |
| C | VAL131 |
| C | CYS166 |
| C | THR167 |
| C | GLY168 |
| C | PHE170 |
| C | GLN323 |
| C | SER326 |
| C | PHE327 |
| C | PHE330 |
| C | HOH2002 |
| site_id | AC8 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE NAP C 501 |
| Chain | Residue |
| C | LYS78 |
| C | PRO176 |
| C | VAL208 |
| C | SER210 |
| C | SER211 |
| C | TYR212 |
| C | SER213 |
| C | ARG234 |
| C | THR235 |
| C | ASN251 |
| C | CYS276 |
| C | THR277 |
| C | GLY278 |
| C | ASN296 |
| C | ASP322 |
| C | GLN323 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PEG C 1453 |
| Chain | Residue |
| A | HIS94 |
| C | ARG234 |
| site_id | BC1 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE FAD D 500 |
| Chain | Residue |
| D | GLY14 |
| D | GLY16 |
| D | PRO17 |
| D | SER18 |
| D | GLU43 |
| D | LYS44 |
| D | GLN45 |
| D | GLY50 |
| D | GLN51 |
| D | TRP52 |
| D | HIS68 |
| D | MET71 |
| D | SER77 |
| D | LYS78 |
| D | THR129 |
| D | ALA130 |
| D | VAL131 |
| D | CYS166 |
| D | THR167 |
| D | GLY168 |
| D | PHE170 |
| D | GLN323 |
| D | SER326 |
| D | PHE327 |
| D | PHE330 |
| D | HOH2002 |
| D | HOH2011 |
| site_id | BC2 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE NAP D 501 |
| Chain | Residue |
| D | LYS78 |
| D | TYR174 |
| D | PRO176 |
| D | VAL208 |
| D | SER210 |
| D | SER211 |
| D | TYR212 |
| D | SER213 |
| D | ARG234 |
| D | THR235 |
| D | ASN251 |
| D | CYS276 |
| D | THR277 |
| D | GLY278 |
| D | ASN296 |
| D | ASP322 |
| D | GLN323 |
| site_id | BC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EPE D 1453 |
| Chain | Residue |
| D | ARG24 |
| D | GLN27 |
| D | GLU31 |
| D | LYS118 |
| D | GLY120 |
| D | LYS123 |
